Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

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Characteristics of a PHD Finger Subtype

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Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases

Martino, L., Brown, N. R., Masino, L., Esposito, D., & Rittinger, K. (2018) · Scientific Reports · doi:10.1038/s41598-017-18513-5 · Cited by 21 · see citing works

Acetylated Ubiquitin Modulates the Catalytic Activity of the E1 Enzyme Uba1

Lacoursiere, R. E., & Shaw, G. S. (2021) · Biochemistry · doi:10.1021/acs.biochem.1c00145 · Cited by 21 · see citing works

Characterization of RING-Between-RING E3 Ubiquitin Transfer Mechanisms

Reiter, K. H., & Klevit, R. E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8706-1_1 · Cited by 20 · see citing works

UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus

Mauro, D., Manou-Stathopoulou, S., Rivellese, F., Sciacca, E., Goldmann, K., Tsang, V., Lucey-Clayton, I., Pagani, S., Alam, F., Pyne, D., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103023 · Cited by 20 · see citing works

Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain

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Capturing the catalytic intermediates of parkin ubiquitination

Connelly, E. M., Rintala‐Dempsey, A. C., Gundogdu, M., Freeman, E. A., Koszela, J., Aguirre, J. D., Zhu, G., Kämäräinen, O., Tadayon, R., Walden, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2403114121 · Cited by 13 · see citing works

Recruitment of Ubiquitin within an E2 Chain Elongation Complex

Cook, B. W., Lacoursiere, R. E., & Shaw, G. S. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.02.012 · Cited by 12 · see citing works

Chemical Tools for Probing the Ub/Ubl Conjugation Cascades

Kochańczyk, T., Fishman, M., & Lima, C. D. (2024) · ChemBioChem · doi:10.1002/cbic.202400659 · Cited by 11 · see citing works

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase

Purser, N., Tripathi‐Giesgen, I., Li, J., Scott, D. C., Horn‐Ghetko, D., Baek, K., Schulman, B. A., Alpi, A. F., & Kleiger, G. (2023) · Biochemical Journal · doi:10.1042/bcj20230373 · Cited by 11 · see citing works

The RING domain of RING Finger 11 ( RNF 11) protein binds Ubc13 and inhibits formation of polyubiquitin chains

Budhidarmo, R., Zhu, J., Middleton, A. J., & Day, C. L. (2018) · FEBS Letters · doi:10.1002/1873-3468.13029 · Cited by 11 · see citing works

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method

Hayashida, R., Kikuchi, R., Imai, K., Kojima, W., Yamada, T., Iijima, M., Sesaki, H., Tanaka, K., Matsuda, N., & Yamano, K. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102822 · Cited by 10 · see citing works

Structural basis for the pathogenicity of parkin catalytic domain mutants

Wagner, J. P., Sauvé, V., Saran, A., & Gehring, K. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.108051 · Cited by 9 · see citing works

Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove

Cheng, P., Hou, Y., Bian, M., Fang, X., Liu, Y., Rao, Y., Cao, S., Liu, Y., Zhang, S., Chen, Y., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05650-z · Cited by 9 · see citing works

Strategies to Trap Enzyme-Substrate Complexes that Mimic Michaelis Intermediates During E3-Mediated Ubiquitin-Like Protein Ligation

Streich, F. C., & Lima, C. D. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8706-1_12 · Cited by 6 · see citing works

ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

Squair, D. R., Rivers, E., Sowar, H., Balci, A., Harmo, R., Wright, D. J., Beniwal, G., Soetens, M., Mathur, S., Tollervey, A., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.02.015 · Cited by 5 · see citing works

Molecular mechanisms of PINK1/Parkin-mediated mitochondrial quality control

Bayne, A. N., & Trempe, J. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.02.014 · Cited by 5 · see citing works

Regulation of germ cell development by ARI1 family ubiquitin ligases in C. elegans

Poush, J. A., Blouin, N. A., Bona, K. R. D., Lažetić, V., & Fay, D. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-35691-y · Cited by 5 · see citing works

Complex Conformational Interplay for Parkin Activation is Revealed by 19F NMR Spectroscopy

Connelly, E. M., & Shaw, G. S. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169397 · Cited by 4 · see citing works

Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling

Kausas, M., Esposito, D., Rittinger, K., & Fraternali, F. (2022) · Scientific Reports · doi:10.1038/s41598-022-18890-6 · Cited by 4 · see citing works

Reversible surface modifications of functional proteins for accelerated cytosolic delivery via cell-penetrating peptide clusters

Hua, X., Guo, Y., Li, P., Wang, Y., Han, X., Chen, J., Li, J., Chu, G.-C., Shi, J., Liu, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70054-6 · Cited by 3 · see citing works

E2 Partner Tunes the Ubiquitylation Specificity of Arkadia E3 Ubiquitin Ligase

Delegkou, G. N., Birkou, M., Fragkaki, N., Toro, T., Marousis, K. D., Episkopou, V., & Spyroulias, G. A. (2023) · Cancers · doi:10.3390/cancers15041040 · Cited by 3 · see citing works

Tools for the discovery of biopolymer producing cysteine relays

Mabbitt, P. D. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00792-y · Cited by 2 · see citing works

RBR Ubiquitin Transfer: Not Simply an “Open” and “Closed” Case?

Dunkerley, K. M., & Shaw, G. S. (2017) · Structure · doi:10.1016/j.str.2017.05.013 · Cited by 2 · see citing works

Review of the Structural Basis of Human E2 Conjugating Enzymes in Complexed with RING E3 Ligases

Gladu, E., Sayed, I., & Massiah, M. A. (2022) · Biochemistry · doi:10.5772/intechopen.101484 · Cited by 1 · see citing works

E3-mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical Probes

Krist, D. T., & Schulman, B. A. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160691-00184

Regulación de la señalización del ABA mediante mecanismos que controlan vida media y actividad de los receptores PYR/PYL

López, M. A. F. (2021) · doi:10.4995/thesis/10251/172364

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

Yuan, L., Lv, Z., Atkison, J. H., & Olsen, S. K. (2017) · Nature Communications · doi:10.1038/s41467-017-00272-6 · Cited by 61 · see citing works

Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms

Dove, K. K., Stieglitz, B., Duncan, E. D., Rittinger, K., & Klevit, R. E. (2016) · EMBO Reports · doi:10.15252/embr.201642641 · Cited by 100 · see citing works

RBR Ubiquitin Transfer: Not Simply an “Open” and “Closed” Case?

Dunkerley, K. M., & Shaw, G. S. (2017) · Structure · doi:10.1016/j.str.2017.05.013 · Cited by 2 · see citing works

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

Duda, D. M., Olszewski, J. L., Schuermann, J. P., Kurinov, I. V., Miller, D. J., Nourse, A., Alpi, A. F., & Schulman, B. A. (2013) · Structure · doi:10.1016/j.str.2013.04.019 · Cited by 140 · see citing works

Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases

Martino, L., Brown, N. R., Masino, L., Esposito, D., & Rittinger, K. (2018) · Scientific Reports · doi:10.1038/s41598-017-18513-5 · Cited by 21 · see citing works