Gasek, Nathan S.

Strategies for targeting senescent cells in human disease

Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 501

The heterogeneity of cellular senescence: insights at the single-cell level

Cohn, R. L., Gasek, N. S., Kuchel, G. A., & Xu, M. (2023) · Trends in Cell Biology

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 294

Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., et al. (2022) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 163

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Wang, B., Wang, L., Gasek, N. S., Zhou, Y., Kim, T., Guo, C., Jellison, E. R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 145

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Wang, B., Wang, L., Gasek, N. S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Zhu, J., Torrance, B. L., Zhou, Y., et al. (2024) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing

Gasek, N. S., Yan, P., Zhu, J., Purushothaman, K.-R., Kim, T., Wang, L., Wang, B., Flynn, W. F., Sun, M., Guo, C., et al. (2024) · Nature Aging

Telomeres, Telomerase, and SenescenceWound Healing and Treatments

Cited by 43

Comparative immunogenicity of decellularized wild type and alpha 1,3 galactosyltransferase knockout pig lungs

Gasek, N., Dearborn, J., Enes, S. R., Pouliot, R., Louie, J., Phillips, Z., Wrenn, S., Uhl, F. E., Riveron, A., Bianchi, J., et al. (2021) · Biomaterials

Tissue Engineering and Regenerative MedicineXenotransplantation and immune response

Cited by 16