Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing
Open accessAbstract
While senescent cells have detrimental roles in several contexts, they are highly heterogeneous. p16 highly expressing senescent cells have been reported to exert beneficial functions in wound healing. Here we use Xenium spatial transcriptomics to identify a distinct p21 highly expressing senescent population induced on wounding, with a pro-inflammatory profile. We find that clearing p21 highly expressing cells expedites wound closure and is partially mediated by NF-κB inhibition, thus enhancing our understanding of the multifaceted functions of senescence in tissue remodeling.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These p21+ cells accumulated across multiple tissues in 23-month-old mice, whereas minimal labeling was present in 3-month-old mice, and their depletion improved lifespan and physical function.
“These p21+ cells also accumulated across multiple tissues in 23-month-old mice, whereas minimal labeling was present in 3-month-old mice, and their depletion improved lifespan and physical function [7,8,13].”
From Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution (2026) · cites this paper as [13]
The paper’s introductory text (indexed under Abstract; page unavailable) says p21-high cells make up 1.5–10% of cells in aged mice but very few in young unstressed mice, and that clearing them extends lifespan and improves age-related health. It does not specify 23- versus 3-month-old mice, labeling across multiple tissues, or a physical-function outcome in its discussion of those findings. (LLM, conf=0.85)
Experimental — accuracy not yet measuredTargeted in situ transcriptomics profiling using Xenium has been applied to senescence during tissue repair, identifying a p21-high senescent population in skin wounds and showing that clearing this population accelerates wound closure.
“Targeted in situ transcriptomics profiling using Xenium has also been applied to senescence during tissue repair, identifying a p21-high senescent population in skin wounds and showing that clearing this population accelerates wound closure [13].”
From Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution (2026) · cites this paper as [13]
p21-Cre dual-reporter mice on C57BL/6 background were generated as previously described.
“p21-Cre dual-reporter mice on C57BL/6 background were generated as previously described [7,8,13].”
From Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution (2026) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159 · see citing works
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring
Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468 · see citing works
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., Zhang, X., LeBrasseur, N. K., Pignolo, R. J., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32552-1 · Cited by 1,060 · see citing works
Self-citationStrategies for targeting senescent cells in human disease
Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging · doi:10.1038/s43587-021-00121-8 · Cited by 501 · cited 3× · see citing works
“4a,b) and the transcriptomic signature (with elevated SASP in p21 high cells; Extended Data Fig.”
InfluentialSelf-citationMolecular Pathogenesis of Chronic Wounds
Stojadinovic, O., Brem, H., Vouthounis, C., Lee, B., Fallon, J., Stallcup, M., Merchant, A., Galiano, R. D., & Tomic-Canic, M. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62953-7 · Cited by 365 · see citing works
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., & Kasper, M. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.01.012 · Cited by 312 · see citing works
Voehringer, D. W., Liang, H.-E., & Locksley, R. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4742 · Cited by 303 · see citing works
The heterogeneity of cellular senescence: insights at the single-cell level
Cohn, R. L., Gasek, N. S., Kuchel, G. A., & Xu, M. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.04.011 · Cited by 294 · cited 1× · see citing works
“However, senescent cells exhibit substantial heterogeneity 4 , implying that p16 high cells may only account for a fraction of the whole senescent cell population.”
Self-citationNair, M. G., Du, Y., Perrigoue, J., Zaph, C., Taylor, J. J., Goldschmidt, M. H., Swain, G. P., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082048 · Cited by 272 · see citing works
Heise, N., Silva, N. S. D., Silva, K., Carette, A., Simonetti, G., Pasparakis, M., & Klein, U. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20132613 · Cited by 220 · see citing works
Characterization of cellular senescence in aging skeletal muscle
Zhang, X., Habiballa, L., Aversa, Z., Ng, Y. E., Sakamoto, A. E., Englund, D. A., Pearsall, V. M., White, T. A., Robinson, M. M., Rivas, D. A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00250-8 · Cited by 206 · cited 2× · see citing works
“In this Article, we showed that p21 high cells are distinct from p16 high cells in skin wounds, similar to other tissues 5,6,8 .”
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.11.002 · Cited by 163 · see citing works
Self-citationWang, B., Wang, L., Gasek, N. S., Zhou, Y., Kim, T., Guo, C., Jellison, E. R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00107-6 · Cited by 145 · see citing works
Self-citationChandra, A., Lagnado, A. B., Farr, J. N., Doolittle, M., Tchkonia, T., Kirkland, J. L., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Aging Cell · doi:10.1111/acel.13602 · Cited by 120 · see citing works
Self-citationElenius, V., Götte, M., Reizes, O., Elenius, K., & Bernfield, M. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404506200 · Cited by 109 · see citing works
Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing
Hsu, I., Parkinson, L. G., Shen, Y., Toro-Montoya, A. I., Brown, T., Zhao, H., Bleackley, R. C., & Granville, D. J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.423 · Cited by 95 · see citing works
PI16 is a shear stress and inflammation-regulated inhibitor of MMP2
Hazell, G. G. J., Peachey, A. M. G., Teasdale, J. E., Sala-Newby, G. B., Angelini, G. D., Newby, A. C., & White, S. J. (2016) · Scientific Reports · doi:10.1038/srep39553 · Cited by 83 · see citing works
Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706949104 · Cited by 73 · see citing works
Wang, B., Wang, L., Gasek, N. S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Zhu, J., Torrance, B. L., Zhou, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.006 · Cited by 59 · see citing works
Self-citationRole of Senescent Cells in Cutaneous Wound Healing
Andrade, A. M., Sun, M., Gasek, N. S., Hargis, G. R., Sharafieh, R., & Xu, M. (2022) · Biology · doi:10.3390/biology11121731 · Cited by 51 · see citing works
Self-citationPharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure
Jozic, I., Sawaya, A. P., Pastar, I., Head, C. R., Wong, L. L., Glinos, G. D., Wikramanayake, T. C., Brem, H., Kirsner, R. S., & Tomic‐Canic, M. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.07.016 · Cited by 43 · see citing works
Wang, Y., Gao, G., Wu, Y., Wang, Y., Wu, X., & Zhou, Q. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.11.19 · Cited by 35 · see citing works
Feng, X., Ji, Y., Zhang, C., Jin, T., Li, J., & Guo, J. (2022) · Experimental Dermatology · doi:10.1111/exd.14718 · Cited by 35 · see citing works
Clinicopathological and cellular senescence biomarkers in chronic stalled wounds
Yu, G., Gomez, P. T., Prata, L. G. P. L., Lehman, J. S., Tchkonia, T., Kirkland, J. L., Meves, A., & Wyles, S. P. (2024) · International Journal of Dermatology · doi:10.1111/ijd.17072 · Cited by 15 · see citing works
Self-citationTakizawa, C., Qin, Q., Haba, D., Sasaki, S., Kawasaki, A., Miyake, T., Oba, J., Kitamura, A., Abe, M., Tomida, S., et al. (2024) · Journal of Tissue Viability · doi:10.1016/j.jtv.2024.07.014 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Advancing biological understanding of cellular senescence with computational multiomics
Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02314-y · Cited by 40 · see citing works
Self-citationTargeting DNA damage in ageing: towards supercharging DNA repair
Bujarrabal-Dueso, A., Garinis, G. A., Robbins, P. D., Vijg, J., & Schumacher, B. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01212-6 · Cited by 30 · see citing works
“At least in older mice, clearance of p21 Cip1 SnCs improved wound healing 153 .”
Tu, H., Shi, Y., Guo, Y., Zou, Z., He, Y., Zhou, J., He, S., & Sa, G. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03293-2 · Cited by 27 · see citing works
“Additionally, clearance of p21-highly expressing senescent cells accelerates skin wound healing, partly mediated by NF-κB inhibition [9].”
Translating cellular senescence research into clinical practice for metabolic disease
Chaib, S., Palmer, A. K., Wyles, S. P., Musi, N., Kirkland, J. L., & Tchkonia, T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01187-9 · Cited by 14 · see citing works
“It should be noted that CAR T cells might persist for an extended period of time, and thus might lead to adverse effects involving processes for which certain types of senescent cells are beneficial, such as wound healing 9,11,159 .”
Self-citationJiang, B., Zhang, H., Xu, Q., Jiang, Z., He, R., Fu, Q., & Sun, Y. (2025) · Aging Cell · doi:10.1111/acel.70138 · Cited by 13 · see citing works
SkinspanTM: A Healthy Longevity Framework for Skin Aging
Wyles, S. P., Maredia, H. S., Ansaf, R. B., Dweydari, M., Hurt, R. T., Bonnes, S. L. R., Khosla, S., LeBrasseur, N. K., Draelos, Z. D., & Davis, M. D. P. (2025) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2025.07.027 · Cited by 14 · see citing works
Self-citationSenSkin™: a human skin-specific cellular senescence gene set
Wyles, S. P., Yu, G., Gânier, C., Tchkonia, T., Lynch, M. D., Kuchel, G. A., & Kirkland, J. L. (2025) · GeroScience · doi:10.1007/s11357-025-01568-y · Cited by 11 · see citing works
“These pathways are consistent with findings that senescent cells affect cutaneous wound healing and modulate the immune system [15, 16].”
Self-citationRedefining senescence through hepatocyte fate changes in liver diseases
Umbaugh, D. S., Diehl, A. M., & Du, K. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.08.003 · Cited by 9 · see citing works
Metabolism, senescence, and natural products: new perspectives on wound healing in diabetes
Wu, J., Yang, Q., Cheng, H., Zheng, H., & Chen, M. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1746827 · Cited by 9 · see citing works
“Research has indicated that not all senescent cells hinder repair; selectively targeting and clearing the p21 high senescent cell subpopulation (rather than broad clearance) can effectively accelerate wound closure and reduce scar formation in female mice (12).”
Biological Aging and Uterine Fibrosis in Cattle: Reproductive Trade-Offs from Enhanced Productivity
Matsuno, Y., & Imakawa, K. (2025) · Cells · doi:10.3390/cells14130955 · Cited by 7 · see citing works
“Recent studies have shown that senescent cells form a heterogeneous population [171,172], highlighting the need for precise elimination strategies targeting senescent cells that contribute to chronic inflammation and hormonal dysregulation, ultimately impairing uterine function and fertility.”
A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models
Lv, D., Ren, L., Zhao, Z., Rong, Y., Chen, M., Yang, H., Yin, R. H., Zeng, R., Chao, H., Li, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65659-2 · Cited by 5 · see citing works
“There is no additional filtering or clustering approaches.”
Spatiotemporal decoding of skin biology: development, aging, disease, and regeneration
Xi, D., Huang, R. S., Li, Y., Xia, Z., & Ji, S. (2026) · Burns & Trauma · doi:10.1093/burnst/tkag019 · Cited by 4 · see citing works
“Clearance of senescent cells at wound edges was found to accelerate wound closure by restoring the reparative capacity of neighboring fibroblasts [ 161], whereas thyroid hormone signaling was found to precisely orchestrate the temporal coordination of epidermal repair and dermal remodeling [ 162].”
Getu, M. A., Zhang, X., Ying, Y., & Gong, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-89288-3 · Cited by 5 · see citing works
Zhang, M., Wang, Y., Dai, Y., Hu, Y., Fu, W., Zhao, Y., Ma, H., Zhang, D., Chen, Y., Zhou, Y., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102741 · Cited by 3 · see citing works
Self-citationNumani, A., Carrasco-Jeldres, M., Hernandez-Rovira, B. B., Purushothaman, K., Melin, M. M., Kirkland, J. L., & Wyles, S. P. (2026) · Advances in Wound Care · doi:10.1177/21621918261426580 · Cited by 3 · see citing works
Self-citationSenescent cell heterogeneity: origins, detection, and therapeutic implications
Wu, R., Zhu, J., Kim, H., & Xu, M. (2026) · Trends in Cell Biology · doi:10.1016/j.tcb.2026.03.015 · Cited by 5 · see citing works
Self-citationYue, Z., Jiang, Z., Yang, Y., Yin, W., Lin, Y., Gao, Y., & Cai, X. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124330 · Cited by 3 · see citing works
Immunological consequences of senescence in physiology and pathology
Zubova, A., Pietrocola, F., & Morsli, S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08335-3 · Cited by 6 · see citing works
“Both targeted inhibition of NF-κB signalling in p21 ⁺ cells and p21 + cell ablation accelerate wound resolution and limit fibrosis, underscoring how distinct senescence programmes shape repair dynamics [71].”
Hou, J., Chen, K.-X., Xiao, Q.-N., Hu, C., Wei, J., Jiang, Y.-Z., Liu, L., He, C., Huang, M., Jiao, Y., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01130-1 · Cited by 3 · see citing works
“Evidence exists that the application of p16-3MR and p16-INK-ATTAC mouse models to deplete p16-positive cells 16,40,41 , as well as the use of an inducible p21 -Cre mouse model to remove p21 high cells 22,39,42,43 , all improved tissue dysfunction during aging.”
Self-citationRNA modifications: molecular orchestrators of wound healing
Guo, X., Liu, L., Yang, J., Dai, Y., Zhang, Q., Gu, R., Tan, M., Tang, M., & Nie, X. (2026) · Burns & Trauma · doi:10.1093/burnst/tkag010 · Cited by 2 · see citing works
Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions
Deng, J., Sun, R., Bai, Z., Fang, L., Zhao, X., & Yang, D. (2026) · Aging · doi:10.18632/aging.206375 · Cited by 2 · see citing works
“Given that distinct senescent subpopulations exert transient physiological benefits during wound healing and tissue repair [15].”
Yang, Q., Liu, C., Wang, Q., An, J., & Cai, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1803023 · Cited by 2 · see citing works
“More recently, selective clearance of p21 high cells has been shown to accelerate cutaneous wound closure, supporting the idea that a p21-dominant arrest program can become rate-limiting for repair execution (40).”
Senotypes define the diverse landscape of senescent cells
Schafer, M. J., Basisty, N., Hertzel, A. V., Rindone, A. N., Elisseeff, J. H., Suryadevara, V., Aliferis, C., Robbins, P. D., Niedernhofer, L. J., Miller, K. N., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01148-5 · Cited by 2 · see citing works
“By contrast, in older mice, clearance of p21 + cells improved wound healing 58 .”
Han, M., Liu, Q., Yang, L., Li, J., Wang, Q., Zhang, Y.-M., Guo, J.-Q., Zeng, L.-T., Qi, R., & Cai, J. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.039 · Cited by 1 · see citing works
Zhou, J., Jiang, S., Wang, L. Z., Dong, T., Yu, L., Li, H., Gao, Z., Wu, J., & Lin, K. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124249 · Cited by 1 · see citing works
Self-citationKong, Y., Zhang, Q., Zhang, J., & Fu, Q. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113249 · Cited by 1 · see citing works
RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair
Zhang, K., Chen, X., Monticolo, F., Sorrentino, S., Huang, H., Callahan, C., Qiao, Y., Zhou, J., Brodowska, S., Sapantzi, S., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01219-7 · Cited by 1 · see citing works
“8a), consistent with a prior report 32 .”
Hsu, J.-E., Wang, B., Hwang, Y., Cheng, W., Zhao, Q., Si, Y., Xu, M., Kang, H.-M., & Lee, J. H. (2026) · Biomolecules · doi:10.3390/biom16040579
“p21-Cre dual-reporter mice on C57BL/6 background were generated as previously described [7,8,13].”
InfluentialSelf-citationMonitoring senescent cell dynamics in wound healing using a p16-tdtomato mouse model
Wang, Q., Shvedova, M., Abdelkader, M., & Roh, D. S. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.12.029
Amancherla, K. V., Lin, P., Perera, B. L. A., Chow, N., Sheng, Q., Siddiqi, H. K., Farber‐Eger, E. H., Wells, Q. S., Freedman, J. E., Schlendorf, K. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.25.681707
Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications
Mao, H., Liu, W., Su, Y., Ma, Y., Zhao, X., & Lu, Y. (2026) · MedComm – Oncology · doi:10.1002/mog2.70060
Liu, Y., Pang, P., Feng, S., Zhong, W., Wang, J., Ye, L. I. U., Zheng, X., Li, Z., Zhou, H., He, Y., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.177852
Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosisPreprint
Rindone, A. N., Nagaraj, S., Cho, A., Browne, M., Krishnan, K., Adkins, R. S., Lesperance, D., Orvis, J., Daswani, P. S., Mejías, J. C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.08.730636
Targeting cellular senescence in dermatology: senolytic and senomorphic strategies
Haykal, D., Flament, F., Garibyan, L., Lee, S., Escot, J., Guéniche, A., & Kirkland, J. L. (2026) · GeroScience · doi:10.1007/s11357-026-02379-5
“Persistent senescent cells can release a SASP comprising IL-6, IL-8, MMP-1, and TGF-β1 among other factors, which can disrupt dermal collagen organization and elastin integrity, leading to wrinkles, laxity, and delayed wound repair [9, 12].”
Self-citationSenescent cell heterogeneity in brain aging and neurodegenerative disease
Graves, S. I., Vasques, P. D. C., & Baker, D. J. (2026) · Neuron · doi:10.1016/j.neuron.2026.06.020
Senescent cells in wounds: Beneficial, neutral, or harmful?
Yu, G., Kirsner, R. S., Kirkland, J. L., & Wyles, S. P. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2026.06.1295
Self-citationSingle-cell mapping of diabetic foot ulcers: mechanistic axes and therapeutic targets
Zhang, H., Tao, M., Yang, C., Sabuj, A. R., Sarker, M. K., & Wang, C. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1910324
“Most proliferating wound-edge keratinocytes lacked the markers used to identify the p21-high population, and genetic clearance of p21-high cells accelerated closure in female mice without producing a comparable benefit in males (60).”
InfluentialWang, T., Wang, H., Guo, W., Xu, L., Feng, L., Feng, C., Zhang, H., & 刘宏宝 (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117311
Deciphering senescence-associated mechanisms through cell painting & transcriptomics
Tan, Y., Liu, A., Larkin, E., Wani, R., Dick, A., Patassini, S., & Erlmann, P. (2026) · npj Aging · doi:10.1038/s41514-026-00500-8
Li, X., Fu, Z., Sun, D., Jin, Z., & Jiao, H. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112258
The chemical fingerprint of cellular senescence
Ma, S., & Qu, J. T. (2026) · Nature Aging · doi:10.1038/s43587-026-01230-y
Wound Healing, Senescence, and Senotherapeutics
Pitcher, L. E., Zhu, J., Schmidt, E. L., Niedernhofer, L. J., Xu, M., & Robbins, P. D. (2026) · Advances in Wound Care · doi:10.1177/21621918261490101
Self-citation
- Authors
- Gasek, N. S., Yan, P., Zhu, J., Purushothaman, K.-R., Kim, T., Wang, L., Wang, B., Flynn, W. F., Sun, M., Guo, C., Huggins, B., Sharafieh, R., Zhou, Y., Parizek, V., Tchkonia, T., Kirkland, J. L., Wyles, S. P., & Xu, M.
- Affiliations
- University of Connecticut (US)
- Mayo Clinic (US)
- The Jackson Laboratory for Genomic Medicine (US)
- UConn Health (US)
- Central South University (CN)
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Xu, Ming
- ORCID
- Venue
- Nature Aging
- Published
- 2024-11-13
- Volume
- 5
- Issue
- 1
- Pages
- 21-27
- ISSN
- 2662-8465 (ISSN-L)
- PMC
- PMC12205026
- OpenAlex
- W4404333936
- Cited by
- 43
- References
- 28
- Citations by year
- 2026: 30 · 2025: 13
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (AG076642, AG079753, AG066679, AG068860, AG072374)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, skin wound healing, senolytics, senescence heterogeneity, NF-κB inhibition, tissue remodeling, spatial transcriptomics
- MeSH terms
- Animals, Dermatitis, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Wound Healing, Oncogene Protein p21(ras), Cellular Senescence, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
