Brouillet, Emmanuel

Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid

Brouillet, E., Jenkins, B. G., Hyman, B. T., Ferrante, R. J., Kowall, N. W., Srivastava, R., Roy, D. S., Rosen, B. R., & Beal, M. F. (1993) · Journal of Neurochemistry

Genetic Neurodegenerative DiseasesMitochondrial Function and Pathology

Cited by 367

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer’s and Huntington’s diseases

Ben Haim, L., Ceyzériat, K., Carrillo-de Sauvage, M. A., Aubry, F., Auregan, G., Guillermier, M., Ruiz, M., Petit, F., Houitte, D., Faivre, E., et al. (2015) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsCytokine Signaling Pathways and Interactions

Cited by 335

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Ceyzériat, K., Ben Haim, L., Denizot, A., Pommier, D., Matos, M., Guillemaud, O., Palomares, M.-A., Abjean, L., Petit, F., Gipchtein, P., et al. (2018) · Acta Neuropathologica Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 256

Cannabinoid CB2receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease

Sagredo, O., González, S., Aroyo, I., Pazos, M. R., Benito, C., Lastres‐Becker, I., Romero, J. P., Tolón, R. M., Mechoulam, R., Brouillet, E., et al. (2009) · Glia

Cannabis and Cannabinoid ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 201

Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia

Jarraya, B., Boulet, S., Scott Ralph, G., Jan, C., Bonvento, G., Azzouz, M., Miskin, J. E., Shin, M., Delzescaux, T., Drouot, X., et al. (2009) · Science Translational Medicine

Parkinson's Disease Mechanisms and TreatmentsVirus-based gene therapy research

Cited by 186

Engineered lentiviral vector targeting astrocytes In vivo

Colin, A., Faideau, M., Dufour, N., Auregan, G., Hassig, R., Andrieu, T., Brouillet, E., Hantraye, P., Bonvento, G., & Déglon, N. (2009) · Glia

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 158

Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo

Ligneul, C., Palombo, M., Hernández-Garzón, E., Carrillo-de Sauvage, M.-A., Flament, J., Hantraye, P., Brouillet, E., Bonvento, G., Escartin, C., & Valette, J. (2019) · NeuroImage

Advanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

Cited by 77

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Galvan, L., Francelle, L., Gaillard, M.-C., de Longprez, L., Carrillo-de Sauvage, M.-A., Liot, G., Cambon, K., Stimmer, L., Luccantoni, S., Flament, J., et al. (2018) · Brain

Genetic Neurodegenerative DiseasesGenetics and Neurodevelopmental Disorders

Cited by 47

In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates

Brouillet, E., Chavoix, C., Bottlaender, M., Khalili-Varasteh, M., Hantraye, P., Fournier, D., Dodd, R. H., & Mazière, M. (1991) · Brain Research

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 37

THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

Vautheny, A., Duwat, C., Aurégan, G., Joséphine, C., Hérard, A.-S., Jan, C., Mitja, J., Gipchtein, P., Gaillard, M.-C., Buée, L., et al. (2021) · Neurobiology of Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 28

Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10

Brouillet, E., Henshaw, D. R., Schulz, J. B., & Beal, M. F. (1994) · Neuroscience Letters

Parkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effects

Cited by 23

In Vivo High Intrinsic Efficacy of Triazolam: A Positron Emission Tomography Study in Nonhuman Primates

Bottlaender, M., Brouillet, E., Varastet, M., Le Breton, C., Schmid, L., Fuseau, C., Sitbon, R., Crouzel, C., & Mazière, M. (1994) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchSynthesis and pharmacology of benzodiazepine derivatives

Cited by 17

Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

Galan‐Rodriguez, B., Martin, E., Brouillet, E., Déglon, N., Betuing, S., & Caboche, J. (2017) · European Journal of Neuroscience

Genetic Neurodegenerative DiseasesReceptor Mechanisms and Signaling

Cited by 5