Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10

Brain Metabolism during Fasting*

Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105650 · Cited by 1,650 · see citing works

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

Beal, M. F. (1992) · Annals of Neurology · doi:10.1002/ana.410310202 · Cited by 956 · see citing works

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

Frei, B. B., Kim, M. C., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4879 · Cited by 623 · see citing works

Alternative excitotoxic hypotheses

Albin, R. L., & Greenamyre, J. T. (1992) · Neurology · doi:10.1212/wnl.42.4.733 · Cited by 574 · see citing works

Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid

Brouillet, E., Jenkins, B. G., Hyman, B. T., Ferrante, R. J., Kowall, N. W., Srivastava, R., Roy, D. S., Rosen, B. R., & Beal, M. F. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05859.x · Cited by 367 · see citing works

Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid

Beal, M. F., Matson, W. R., Swartz, K. J., Gamache, P. H., & Bird, E. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb03143.x · Cited by 312 · see citing works

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

Heikkila, R. E., Nicklas, W. J., Vyas, I. L., & Duvoisin, R. C. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90580-4 · Cited by 302 · see citing works

Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats

Ruderman, N. B., Ross, P. S., Berger, M., & Goodman, M. N. (1974) · Biochemical Journal · doi:10.1042/bj1380001 · Cited by 239 · see citing works

1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism

Storey, E., Hyman, B. T., Jenkins, B. G., Brouillet, E., Miller, J. M., Rosen, B. R., & Beal, M. F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10080.x · Cited by 164 · see citing works

Mitochondrial encephalomyopathy (MELAS): Pathological study and successful therapy with coenzyme Q10 and idebenone

Ihara, Y., Namba, R., Kuroda, S., SATO, T. A., & Shirabe, T. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90112-3 · Cited by 161 · see citing works

Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

Beal, M. F., Swartz, K. J., Hyman, B. T., Storey, E., Finn, S. F., & Koroshetz, W. J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08258.x · Cited by 118 · see citing works

Lateral diffusion of ubiquinone during electron transfer in phospholipid- and ubiquinone-enriched mitochondrial membranes.

Schneider, H., Lemasters, J. J., & Hackenbrock, C. R. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33893-6 · Cited by 110 · see citing works

Therapy of mitochondrial disorders

Przyrembel, H. (1987) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01812853 · Cited by 102 · see citing works

Long‐term coenzyme Q 10 therapy for a mitochondrial encephalomyopathy with cytochrome c oxidase deficiency

Nishikawa, Y., Takahashi, M. M., Yorifuji, S., Nakamura, Y., Ueno, S., Tarui, S., Kozuka, T., & Nishimura, T. (1989) · Neurology · doi:10.1212/wnl.39.3.399 · Cited by 100 · see citing works

Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration

Favit, A., Nicoletti, F., Scapagnini, U., & Canonico, P. L. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.88 · Cited by 98 · see citing works

Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

Abe, K., Fujimura, H., Nishikawa, Y., Yorifuji, S., Mezaki, T., Hirono, N., Nishitani, N., & Kameyama, M. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb03962.x · Cited by 76 · see citing works

A protective effect of coenzyme Q10 on ischemia and reperfusion of the isolated perfused rat heart

Ohhara, H. (1981) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(81)90229-7 · Cited by 74 · see citing works

Protective Action of 1,3-Butanediol in Cerebral Ischemia. A Neurologic, Histologic, and Metabolic Study

Marie, C., Bralet, A. M., & Bralet, J. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.136 · Cited by 34 · see citing works

Reduction of neurologic deficit by 1,3-butanediol induced ketosis in levine rats.

Lundy, E. F., Dykstra, J. A., Luyckx, B. A., Zelenock, G. B., & D’Alecy, L. G. (1985) · Stroke · doi:10.1161/01.str.16.5.855 · Cited by 29 · see citing works

Butanediol induced cerebral protection from ischemic-hypoxia in the instrumented Levine rat.

Lundy, E. F., Luyckx, B. A., Combs, D. J., Zelenock, G. B., & D’Alecy, L. G. (1984) · Stroke · doi:10.1161/01.str.15.3.547 · Cited by 27 · see citing works

Beneficial effect of 1,3-butanediol on cerebral energy metabolism and edema following brain embolization in rats.

Gueldry, S., Marie, C., Rochette, L., & Bralet, J. (1990) · Stroke · doi:10.1161/01.str.21.10.1458 · Cited by 25 · see citing works

Coenzyme Q ₁₀ administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557 · see citing works

Replicating Huntington's disease phenotype in experimental animals

Brouillet, E. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00005-2 · Cited by 413 · see citing works

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

Whiteman, M., Trionnaire, S. L., Chopra, M., Fox, B. C., & Whatmore, J. L. (2011) · Clinical Science · doi:10.1042/cs20110267 · Cited by 310 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Bioenergetic approaches for neuroprotection in Parkinson's disease

Beal, M. F. (2003) · Annals of Neurology · doi:10.1002/ana.10479 · Cited by 236 · see citing works

Coenzyme Q 10 as a Possible Treatment for Neurodegenerative Diseases

Beal, M. F. (2002) · Free Radical Research · doi:10.1080/10715760290021315 · Cited by 160 · see citing works

Three Classes of Ubiquinone Analogs Regulate the Mitochondrial Permeability Transition Pore through a Common Site

Walter, L., Nogueira, V., Leverve, X. M., Heitz, M., Bernardi, P., & Fontaine, E. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004128200 · Cited by 146 · see citing works

Progress on the Mitochondrial Permeability Transition Pore: Regulation by Complex I and Ubiquinone Analogs

Fontaine, E. M., & Bernardi, P. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005475802350 · Cited by 146 · see citing works

Coenzyme Q10administration and its potential for treatment of neurodegenerative diseases

Beal, M. F. (1999) · BioFactors · doi:10.1002/biof.5520090222 · Cited by 111 · see citing works

Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease

Beal, M. F., & Shults, C. W. (2003) · BioFactors · doi:10.1002/biof.5520180218 · Cited by 58 · see citing works

Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: reversal by lactate and pyruvate

Hodgkins, P., & Schwarcz, R. M. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00208.x · Cited by 59 · see citing works

Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases

Beal, M. F., & Matthews, R. T. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00024-1 · Cited by 58 · see citing works

Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases

Beal, M. F. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)82026-3 · Cited by 54 · see citing works

Targeting cellular energy production in neurological disorders

Baker, S. K., & Tarnopolsky, M. A. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.10.1655 · Cited by 43 · see citing works

NEUROPROTECTIVE THERAPIES

Simon, D. K., & Standaert, D. G. (1999) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70117-6 · Cited by 30 · see citing works

Focal Microinjection of γ-Acetylenic GABA into the Rat Entorhinal Cortex: Behavioral and Electroencephalographic Abnormalities and Preferential Neuron Loss in Layer III

Wu, H., & Schwarcz, R. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6908 · Cited by 14 · see citing works

Rotenone-induced Parkinson`s Like Disease: Modulating Role of Coenzyme Q10

., H. M. A.-E. G., Abdallah, D. M., & El-Abhar, H. S. (2004) · Journal of Biological Sciences · doi:10.3923/jbs.2004.568.574 · Cited by 12 · see citing works

Coenzyme Q10 Does Not Prevent Oral Dyskinesias Induced by Long-Term Haloperidol Treatment of Rats

Andreassen, O. A., Weber, C., & Jørgensen, H. A. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00118-5 · Cited by 10 · see citing works

Central administration of aminooxyacetate, an inhibitor of H2S production, affects thermoregulatory but not cardiovascular and ventilatory responses to hypercapnia in spontaneously hypertensive rats

Sabino, J. P. J., Soriano, R. N., Santos, B. M., Donatti, A. F., Fernández, R. A. R., da Silva, G. S. F., & Branco, L. G. S. (2019) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2019.03.001 · Cited by 9 · see citing works

Excitotoxicity*

Lau, A., & Tymianski, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01331-2 · Cited by 2 · see citing works

Therapeutics in Huntington’s Disease

Rosas, H. D., & Koroshetz, W. J. (2002) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-06274-6_17 · Cited by 2 · see citing works

Systemic Administration of 3-Nitropropionic Acid

Brouillet, E., Hantraye, P., & Beal, M. F. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-691-1_16 · Cited by 2 · see citing works

Neurodegeneration caused by mitochondrial complex I dysfunction in the mouse retina

Zhang, X. (2005) · Texas ScholarWorks (Texas Digital Library)

Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

Beal, M. F., Swartz, K. J., Hyman, B. T., Storey, E., Finn, S. F., & Koroshetz, W. J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08258.x · Cited by 118 · see citing works

Aminooxyacetic acid produces excitotoxic lesions in the rat striatum

Urbańska, E. M., Ikonomidou, C., Sieklucka, M., & Turski, W. A. (1991) · Synapse · doi:10.1002/syn.890090207 · Cited by 66 · see citing works

Quinolinate-like neurotoxicity produced by aminooxyacetic acid in rat striatum

Turski, W. A., Urbańska, E. M., Sieklucka, M., & Ikonomidou, C. (1992) · Amino Acids · doi:10.1007/bf00805946 · Cited by 2 · see citing works

Coenzyme Q₁₀ and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

Beal, M. F., Henshaw, D. R., Jenkins, B. G., Rosen, B. R., & Schulz, J. B. (1994) · Annals of Neurology · doi:10.1002/ana.410360613 · Cited by 189 · see citing works

Age‐Dependent Neurotoxicity of Striatal Lesions Produced by Aminooxyacetic Acid: Quantitative In Vitro 1H NMR Spectroscopic Studies

Chang, C., & Jang, T. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031192.x · Cited by 13 · see citing works