Saghatelian, Alan

How many human proteoforms are there?

Aebersold, R., Agar, J. N., Amster, I. J., Baker, M. S., Bertozzi, C. R., Boja, E. S., Costello, C. E., Cravatt, B. F., Fenselau, C., Garcia, B. A., et al. (2018) · Nature Chemical Biology

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 907

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

Zarrinpar, A., Chaix, A., Xu, Z. Z., Chang, M. W., Marotz, C. A., Saghatelian, A., Knight, R., & Panda, S. (2018) · Nature Communications

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 546

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Svensson, R. U., Parker, S. J., Eichner, L. J., Kolar, M. J., Wallace, M., Brun, S. N., Lombardo, P. S., Van Nostrand, J. L., Hutchins, A., Vera, L., et al. (2016) · Nature Medicine

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 536

Metformin Inhibits Hepatic Mtorc1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex

Howell, J. J., Hellberg, K., Turner, M., Talbott, G., Kolar, M. J., Ross, D. S., Hoxhaj, G., Saghatelian, A., Shaw, R. J., & Manning, B. D. (2017) · Cell Metabolism

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 408

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

Oishi, Y., Spann, N. J., Link, V. M., Muse, E. D., Strid, T., Edillor, C., Kolar, M. J., Matsuzaka, T., Hayakawa, S., Tao, J., et al. (2017) · Cell Metabolism

Fatty Acid Research and HealthImmune Response and Inflammation

Cited by 342

A chiroselective peptide replicator

Saghatelian, A., Yokobayashi, Y., Soltani, K., & Ghadiri, M. R. (2001) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 310

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C. W., Boulton, S. J., Saghatelian, A., et al. (2017) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 299

Discovery and characterization of smORF-encoded bioactive polypeptides

Saghatelian, A., & Couso, J. P. (2015) · Nature Chemical Biology

RNA and protein synthesis mechanismsGenomics and Phylogenetic Studies

Cited by 286

Revealing disease-associated pathways by network integration of untargeted metabolomics

Pirhaji, L., Milani, P., Leidl, M., Curran, T., Avila-Pacheco, J., Clish, C. B., White, F. M., Saghatelian, A., & Fraenkel, E. (2016) · Nature Methods

Bioinformatics and Genomic NetworksMetabolomics and Mass Spectrometry Studies

Cited by 167

Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes

Russell, B. J., Brown, S. D., Siguenza, N., Mai, I., Saran, A. R., Lingaraju, A., Maissy, E. S., Dantas Machado, A. C., Pinto, A. F. M., Sanchez, C., et al. (2022) · Cell

Bacterial Cancer TherapyGut microbiota and health

Cited by 151

The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina

Chen, D., Chao, D. L., Rocha, L., Kolar, M., Nguyen Huu, V. A., Krawczyk, M., Dasyani, M., Wang, T., Jafari, M., Jabari, M., et al. (2020) · Aging Cell

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 109

Global strategies to integrate the proteome and metabolome

Saghatelian, A., & Cravatt, B. F. (2005) · Current Opinion in Chemical Biology

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 85

HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective

Chu, Q., Diedrich, J. K., Vaughan, J. M., Donaldson, C. J., Nunn, M. F., Lee, K.-F., & Saghatelian, A. (2016) · Journal of the American Chemical Society

Alzheimer's disease research and treatmentsProtease and Inhibitor Mechanisms

Cited by 46

Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition

Sander, C. L., Sears, A. E., Pinto, A. F. M., Choi, E. H., Kahremany, S., Gao, F., Salom, D., Jin, H., Pardon, E., Suh, S., et al. (2021) · Journal of Cell Biology

Lipid Membrane Structure and BehaviorLipid metabolism and biosynthesis

Cited by 36