A chiroselective peptide replicator

Saghatelian, Alan; Yokobayashi, Yohei; Soltani, Kathy; Ghadiri, M. Reza

doi:10.1038/35057238

Cited by 311Origins and Evolution of LifeRNA and protein synthesis mechanismsChemical Synthesis and Analysis

A chiroselective peptide replicator

Saghatelian, Alan, Yokobayashi, Yohei, Soltani, Kathy, Ghadiri, M. Reza·2001·Nature

DOI 10.1038/35057238

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Abstract

The origin of homochirality in living systems is often attributed to the generation of enantiomeric differences in a pool of chiral prebiotic molecules, but none of the possible physiochemical processes considered can produce the significant imbalance required if homochiral biopolymers are to result from simple coupling of suitable precursor molecules. This implies a central role either for additional processes that can selectively amplify an initially minute enantiomeric difference in the starting material, or for a nonenzymatic process by which biopolymers undergo chiroselective molecular replication. Given that molecular self-replication and the capacity for selection are necessary conditions for the emergence of life, chiroselective replication of biopolymers seems a particularly attractive process for explaining homochirality in nature. Here we report that a 32-residue peptide replicator, designed according to our earlier principles, is capable of efficiently amplifying homochiral products from a racemic mixture of peptide fragments through a chiroselective autocatalytic cycle. The chiroselective amplification process discriminates between structures possessing even single stereochemical mutations within otherwise homochiral sequences. Moreover, the system exhibits a dynamic stereochemical 'editing' function; in contrast to the previously observed error correction, it makes use of heterochiral sequences that arise through uncatalysed background reactions to catalyse the production of the homochiral product. These results support the idea that self-replicating polypeptides could have played a key role in the origin of homochirality on Earth.

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Electrophilic and nucleophilic 16-residue peptide fragments of the same handedness were preferentially ligated, even in the presence of their enantiomers (ca.70% diastereomeric excess).
“Electrophilic and nucleophilic 16-residue peptide fragments of the same handedness were preferentially ligated, even in the presence of their enantiomers (ca.70% of diastereomeric excess was reached when peptide fragments E L , E D , N E , and N D were engaged, Fig. 21).”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [539]
The process is very sensitive to the optical purity of the substrates; fragments embedding a single (S)/(R) amino acid substitution lacked significant auto-catalytic properties.
“The process is very sensitive to the optical purity of the substrates, fragments embedding a single (S)/(R) amino acid substitution lacked significant auto-catalytic properties.”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [539]
Stereochemical mismatches were tolerated in the replicator; single mutated templates were able to couple homochiral fragments.
“On the contrary, stereochemical mismatches were tolerated in the replicator; single mutated templates were able to couple homochiral fragments”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [539]
Stereoselective replication of peptide residues with the same handedness occurs.
“Schematic representation of the stereoselective replication of peptide residues with the same handedness.”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [539]

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse‐Kunstleve, R. W., Jiang, J., Kuszewski, J. J., Nilges, M., Pannu, N., et al. (1998) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444998003254 · Cited by 15,720 · see citing works
Micromechanics of defects in solids
Mura, T. (1987) · Mechanics of elastic and inelastic solids · doi:10.1007/978-94-009-3489-4 · Cited by 5,563 · see citing works
Synthesis of Proteins by Native Chemical Ligation
Dawson, P. E., Muir, T. W., Clark‐Lewis, I., & Kent, S. B. H. (1994) · Science · doi:10.1126/science.7973629 · Cited by 4,142 · see citing works
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,726 · see citing works
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S., Tsai, S., Tsai, M.-J., & O'Malley, B. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,507 · see citing works
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128 · see citing works
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
Nolte, R. T., Wisely, G. B., Westin, S. K., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., & Milburn, M. V. (1998) · Nature · doi:10.1038/25931 · Cited by 1,955 · see citing works
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
Harbury, P. B., Zhang, T., Kim, P. S., & Alber, T. (1993) · Science · doi:10.1126/science.8248779 · Cited by 1,490 · see citing works
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169 · see citing works
A theory crack healing in polymers
Wool, R. P., & O’Connor, K. M. (1981) · Journal of Applied Physics · doi:10.1063/1.328526 · Cited by 1,093 · see citing works
Asymmetric autocatalysis and amplification of enantiomeric excess of a chiral molecule
Soai, K., Shibata, T., Morioka, H., & Choji, K. (1995) · Nature · doi:10.1038/378767a0 · Cited by 1,085 · see citing works
Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
Grignani, F., Matteis, S. D., Nervi, C., Tomassoni, L., Gelmetti, V., Cioce, M., Fanelli, M., Ruthardt, M., Ferrara, F. F., Zamir, I., et al. (1998) · Nature · doi:10.1038/35901 · Cited by 1,004 · see citing works
Chiral Symmetry Breaking in Sodium Chlorate Crystallization
Kondepudi, D. K., Kaufman, R. J., & Singh, N. (1990) · Science · doi:10.1126/science.250.4983.975 · Cited by 965 · see citing works
Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression
Laherty, C. D., Yang, W., Sun, J.-M., Davie, J., Seto, E., & Eisenman, R. N. (1997) · Cell · doi:10.1016/s0092-8674(00)80215-9 · Cited by 933 · see citing works
Structure and specificity of nuclear receptor–coactivator interactionsPreprint
Darimont, B. D., Wagner, R. L., Apriletti, J. W., Stallcup, M. R., Kushner, P. J., Baxter, J. D., Fletterick, R. J., & Yamamoto, K. R. (1998) · Genes & Development · doi:10.1101/gad.12.21.3343 · Cited by 921 · see citing works
On spontaneous asymmetric synthesis
Frank, F. C. (1953) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(53)90082-1 · Cited by 905 · see citing works
Enantiomeric Excesses in Meteoritic Amino Acids
Cronin, J. R., & Pizzarello, S. (1997) · Science · doi:10.1126/science.275.5302.951 · Cited by 889 · see citing works
Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A
Hassig, C. A., Fleischer, T. C., Billin, A. N., Schreiber, S. L., & Ayer, D. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80214-7 · Cited by 740 · see citing works
A self-replicating peptide
Lee, D. H., Granja, J. R., Martinez, J. A., Severin, K., & Ghadiri, M. R. (1996) · Nature · doi:10.1038/382525a0 · Cited by 677 · see citing works
Self-citation
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
Hu, X., & Lazar, M. A. (1999) · Nature · doi:10.1038/47069 · Cited by 642 · see citing works
Fracture mechanics studies of crack healing and welding of polymers
Jud, K., Kausch, H. H., & Williams, J. G. (1981) · Journal of Materials Science · doi:10.1007/bf00552073 · Cited by 601 · see citing works
The origin and amplification of biomolecular chirality
Bonner, W. A. (1991) · Origins of life and evolution of the biosphere · doi:10.1007/bf01809580 · Cited by 557 · see citing works
Chemical evolution.
Calvin, M. (1969) · PubMed · Cited by 548 · see citing works
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Plunket, K. D., Moore, L. B., Collins, J. L., Oplinger, J. A., Kliewer, S. A., Gampe, R. T., McKee, D. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241410198 · Cited by 541 · see citing works
Procedures developed for self-repair of polymer matrix composite materials
Dry, C. M. (1996) · Composite Structures · doi:10.1016/0263-8223(96)00033-5 · Cited by 536 · see citing works
Molecular determinants of nuclear receptor-corepressor interactionPreprint
Perissi, V., Staszewski, L. M., McInerney, E. M., Kurokawa, R., Krones, A., Rose, D. W., L., L. M., Milburn, M. V., Glass, C. K., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.24.3198 · Cited by 514 · see citing works
The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT
Jackson, T. A., Richer, J. K., Bain, D. L., Takimoto, G. S., Tung, L. W., & Horwitz, K. B. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0004 · Cited by 479 · see citing works
Polymer Synthesis and Organotransition Metal Chemistry
Grubbs, R. H., & Tumas, W. (1989) · Science · doi:10.1126/science.2645643 · Cited by 475 · see citing works
Mechanism of corepressor binding and release from nuclear hormone receptorsPreprint
Nagy, L., Kao, H., Love, J. D., Li, C. W., Banayo, E., Gooch, J. T., Krishna, V., Chatterjee, K., Evans, R. M., & Schwabe, J. W. R. (1999) · Genes & Development · doi:10.1101/gad.13.24.3209 · Cited by 419 · see citing works
Chiral selection in poly(C)-directed synthesis of oligo(G)
Joyce, G. F., Visser, G. M., van Boeckel, C. A. A., van Boom, J. H., Orgel, L. E., & van Westrenen, J. (1984) · Nature · doi:10.1038/310602a0 · Cited by 398 · see citing works
Weak neutral currents and the origin of biomolecular chirality
Kondepudi, D. K., & Nelson, G. W. (1985) · Nature · doi:10.1038/314438a0 · Cited by 375 · see citing works
Polymer interfaces: Structure and strength
(1996) · Reactive and Functional Polymers · doi:10.1016/s1381-5148(96)90013-9 · Cited by 355 · see citing works
Damage mechanics of composite materials
Talreja, R. (1994) · Elsevier eBooks · Cited by 343 · see citing works
SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia
Hong, S.-H., David, G., Wong, C.-W., Dejean, A., & Privalsky, M. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9028 · Cited by 341 · see citing works
Luminescent oxygen channeling immunoassay: measurement of particle binding kinetics by chemiluminescence.
Ullman, E. F., Kirakossian, H., Singh, S., Wu, Z., Irvin, B. R., Pease, J., Switchenko, A. C., Irvine, J. D., Dafforn, A., & Skold, C. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5426 · Cited by 338 · see citing works
A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation
Oberfield, J. L., Collins, J. L., Holmes, C. P., Goreham, D. M., Cooper, J. P., Cobb, J. E., Lenhard, J. M., Hull-Ryde, E. A., Mohr, C. P., Blanchard, S. G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6102 · Cited by 311 · see citing works
Pyranosyl-RNA: chiroselective self-assembly of base sequences by ligative oligomerization of tetra nucleotide-2′,3′-cyclophosphates (with a commentary concerning the origin of biomolecular homochirality)
Bolli, M., Micura, R., & Eschenmoser, A. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90074-0 · Cited by 290 · see citing works
Origins of homochirality
Bada, J. L. (1995) · Nature · doi:10.1038/374594a0 · Cited by 267 · see citing works
Emergence of symbiosis in peptide self-replication through a hypercyclic network
Lee, D. H., Severin, K., Yokobayashi, Y., & Ghadiri, M. R. (1997) · Nature · doi:10.1038/37569 · Cited by 265 · see citing works
Self-citation
Differing roles for zinc fingers in DNA recognition: Structure of a six-finger transcription factor IIIA complex
Nolte, R. T., Conlin, R. M., Harrison, S. C., & Brown, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2938 · Cited by 245 · see citing works
Thyroid Hormone Resistance Syndrome Manifests as an Aberrant Interaction between Mutant T3 Receptors and Transcriptional Corepressors
Yoh, S. M., Chatterjee, K., & Privalsky, M. L. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9914 · Cited by 219 · see citing works
Homochiral imperative of molecular evolution
Siegel, J. S. (1998) · Chirality · doi:10.1002/chir.5 · Cited by 218 · see citing works
Fatigue damage mechanisms in unidirectional carbon-fibre-reinforced plastics
Gamstedt, E. K., & Talreja, R. (1999) · Journal of Materials Science · doi:10.1023/a:1004684228765 · Cited by 212 · see citing works
Nuclear Receptors Have Distinct Affinities for Coactivators: Characterization by Fluorescence Resonance Energy Transfer
Zhou, G., Cummings, R. T., Li, Y., Mitra, S. W., Wilkinson, H. A., Elbrecht, A., Hermes, J. D., Schaeffer, J. M., Smith, R. G., & Moller, D. E. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.10.0176 · Cited by 171 · see citing works
Load transfer through chain molecules after interpenetration at interfaces
Jud, K., & Kausch, H. H. (1979) · Polymer Bulletin · doi:10.1007/bf00255445 · Cited by 164 · see citing works
Crack Healing in Glass
Wiederhorn, S. M., & Townsend, P. R. (1970) · Journal of the American Ceramic Society · doi:10.1111/j.1151-2916.1970.tb15996.x · Cited by 143 · see citing works
Synthesis and Reactivity of Neutral and Cationic Ruthenium(II) Tris(pyrazolyl)borate Alkylidenes
Sanford, M. S., Henling, L. M., & Grubbs, R. H. (1998) · Organometallics · doi:10.1021/om980683f · Cited by 127 · see citing works
Methanol‐Induced crack healing in poly(methyl methacrylate)
Lin, C. B., Lee, S., & Liu, K. S. (1990) · Polymer Engineering and Science · doi:10.1002/pen.760302109 · Cited by 120 · see citing works
Discrete Roles for Peroxisome Proliferator-Activated Receptor γ and Retinoid X Receptor in Recruiting Nuclear Receptor Coactivators
Yang, W., Rachez, C., & Freedman, L. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8008-8017.2000 · Cited by 120 · see citing works
Peptide Self‐Replication Via Template‐Directed Ligation
Severin, K., Lee, D. H., Martinez, J. A., & Ghadiri, M. R. (1997) · Chemistry - A European Journal · doi:10.1002/chem.19970030706 · Cited by 110 · see citing works
Self-citation
The Helix-Destabilizing Propensity Scale of d -Amino Acids: The Influence of Side Chain Steric Effects
Krause, E., Bienert, M., Schmieder, P., & Wenschuh, H. (2000) · Journal of the American Chemical Society · doi:10.1021/ja9940524 · Cited by 102 · see citing works
Enantiomeric Cross-Inhibition in the Synthesis of Oligonucleotides on a Nonchiral Template
Schmidt, J. G., Nielsen, P. E., & Orgel, L. E. (1997) · Journal of the American Chemical Society · doi:10.1021/ja963563c · Cited by 94 · see citing works
Ethanol‐induced crack healing in poly(methyl methacrylate)
Wang, P. H., Lee, S., & Harmon, J. P. (1994) · Journal of Polymer Science Part B Polymer Physics · doi:10.1002/polb.1994.090320709 · Cited by 93 · see citing works
Spontaneous generation and amplification of optical activity in α-amino acids by enantioselective occlusion into centrosymmetric crystals of glycine
Weissbuch, I., Addadi, L., Berkovitch-Yellin, Z., Gati, E., Lahav, M., & Leiserowitz, L. (1984) · Nature · doi:10.1038/310161a0 · Cited by 93 · see citing works
Damage development in composites: Mechanisms and modelling
Talreja, R. (1989) · The Journal of Strain Analysis for Engineering Design · doi:10.1243/03093247v244215 · Cited by 83 · see citing works
Structure Effects of Double D-Amino Acid Replacements: A Nuclear Magnetic Resonance and Circular Dichroism Study Using Amphipathic Model Helixes
Rothemund, S., Beyermann, M., Krause, E., Krause, G., Bienert, M., Hodges, R. S., Sykes, B. D., & Sönnichsen, F. D. (1995) · Biochemistry · doi:10.1021/bi00040a005 · Cited by 61 · see citing works
Crystallization of Calcite Spherules around Designer Nuclei
Küther, J., Seshadri, R., & Tremel, W. (1998) · Angewandte Chemie International Edition · doi:10.1002/(sici)1521-3773(19981116)37:21 · Cited by 53 · see citing works
A Highly Enantio-Selective Hexitol Nucleic Acid Template for Nonenzymatic Oligoguanylate Synthesis
Ia, K., Politis, P. K., Pitsch, S., Herdewijn, P. A., & Orgel, L. E. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9836489 · Cited by 46 · see citing works
Experiments on the abiotic amplification of optical activity
Bonner, W. A., Blair, N. E., & Dirbas, F. M. (1981) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf00928003 · Cited by 36 · see citing works
Work of Fracture and Crack Healing in Glass
Inagaki, M., Urashima, K., Toyomasu, S., Goto, Y., & Sakai, M. (1985) · Journal of the American Ceramic Society · doi:10.1111/j.1151-2916.1985.tb10129.x · Cited by 35 · see citing works
Stereoselection in designed three-helix bundle metalloproteins
Case, M. A., Ghadiri, M., Mutz, M. W., & Lendon, G. L. M. (1998) · Chirality · doi:10.1002/chir.7 · Cited by 24 · see citing works
Self-citation
Stress and strain oscillations in syndiotactic polypropylene and in poly(ethyleneterephthalate)
Ebener, H., Pleuger, B., & Petermann, J. (1999) · Journal of Applied Polymer Science · doi:10.1002/(sici)1097-4628(19990131)71:5 · Cited by 23 · see citing works
Peptide destabilization by two adjacent D-amino acids in single-stranded amphipathic alpha-helices.
Rothemund, S., Krause, E., Beyermann, M., Dathe, M., Bienert, M., Rs, H., Bd, S., & Sönnichsen, F. D. (1996) · PubMed · Cited by 17 · see citing works
Influence of secondary structure (helical conformation) on stereoselectivity in peptide couplings
Li, T., Budt, K., & Kishi, Y. (1987) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39870001817 · Cited by 8 · see citing works
Aerogels—Airy Materials: Chemistry, Structure, and Properties
(1998) · doi:10.1002/(sici)1521-3773(19980202)37:1/2
Self-citation

Flagged first, then by citations

2 of the 70 references couldn’t be matched to a known paper.

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Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930 · see citing works
Supramolecular catalysis. Part 2: artificial enzyme mimics
Raynal, M., Ballester, P., Vidal‐Ferran, A., & van Leeuwen, P. W. N. M. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60037h · Cited by 928 · see citing works
Synthetic biology
Benner, S. A., & Sismour, A. M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1637 · Cited by 834 · see citing works
Chemoselective Ligation and Modification Strategies for Peptides and Proteins
Hackenberger, C. P. R., & Schwarzer, D. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801313 · Cited by 760 · see citing works
Prions as adaptive conduits of memory and inheritance
Shorter, J., & Lindquist, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1616 · Cited by 555 · see citing works
Synthesis Beyond the Molecule
Reinhoudt, D. N., & Crego‐Calama, M. (2002) · Science · doi:10.1126/science.1069197 · Cited by 494 · see citing works
Chiral selection on inorganic crystalline surfaces
Hazen, R. M., & Sholl, D. S. (2003) · Nature Materials · doi:10.1038/nmat879 · Cited by 488 · see citing works
Self-Sorting: The Exception or the Rule?
Wu, A., & Isaacs, L. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028913b · Cited by 460 · see citing works
Active Anticorrosion Coatings with Halloysite Nanocontainers
Shchukin, D. G., Lamaka, S. V., Yasakau, K. A., Zheludkevich, M. L., Ferreira, M. G. S., & Möhwald, H. (2008) · The Journal of Physical Chemistry C · doi:10.1021/jp076188r · Cited by 395 · see citing works
Mechanisms of Autocatalysis
Bissette, A. J., & Fletcher, S. P. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201303822 · Cited by 403 · see citing works
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Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354 · see citing works
Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures
Herrmann, A. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60336a · Cited by 351 · see citing works
Asymmetric autocatalysis and its implications for the origin of homochirality
Blackmond, D. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308363101 · Cited by 328 · see citing works
Next-generation peptide nanomaterials: molecular networks, interfaces and supramolecular functionality
Zelzer, M., & Ulijn, R. V. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00035c · Cited by 302 · see citing works
Solvent-Promoted Self-Healing Epoxy Materials
Caruso, M. M., Delafuente, D. A., Ho, V., Sottos, N. R., Moore, J. S., & White, S. R. (2007) · Macromolecules · doi:10.1021/ma701992z · Cited by 299 · see citing works
A Contrivance for a Dynamic Porous Framework: Cooperative Guest Adsorption Based on Square Grids Connected by Amide−Amide Hydrogen Bonds
Uemura, K., Kitagawa, S., Fukui, K., & Saito, K. (2004) · Journal of the American Chemical Society · doi:10.1021/ja039914m · Cited by 296 · see citing works
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Weissbuch, I., & Lahav, M. (2011) · Chemical Reviews · doi:10.1021/cr1002479 · Cited by 284 · see citing works
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Fenniri, H., Deng, B., & Ribbe, A. E. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026164s · Cited by 287 · see citing works
Utilization of a Combination of Weak Hydrogen-Bonding Interactions and Phase Segregation to Yield Highly Thermosensitive Supramolecular Polymers
Sivakova, S., Bohnsack, D. A., Mackay, M. E., Suwanmala, P., & Rowan, S. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja055245w · Cited by 286 · see citing works
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Rasmussen, S., Chen, L., Nilsson, M., & Abe, S. (2003) · Artificial Life · doi:10.1162/106454603322392479 · Cited by 266 · see citing works
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Eschenmoser, A. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.10.012 · Cited by 292 · see citing works
Designing artificial enzymes by intuition and computation
Nanda, V., & Koder, R. L. (2009) · Nature Chemistry · doi:10.1038/nchem.473 · Cited by 264 · see citing works
ROMP Reactivity of e ndo - and e xo -Dicyclopentadiene
Rule, J. D., & Moore, J. S. (2002) · Macromolecules · doi:10.1021/ma0209489 · Cited by 266 · see citing works
Dynamic combinatorial chemistry: on the road to fulfilling the promise
Ladame, S. (2007) · Organic & Biomolecular Chemistry · doi:10.1039/b714599c · Cited by 242 · see citing works
Peptides as novel smart materials
Fairman, R., & Åkerfeldt, K. S. (2005) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2005.07.005 · Cited by 232 · see citing works
Design of a directed molecular network
Ashkenasy, G., Jagasia, R., Yadav, M. K., & Ghadiri, M. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402674101 · Cited by 225 · see citing works
Self-citation
Chemoselektive Ligations‐ und Modifikationsstrategien für Peptide und Proteine
Hackenberger, C. P. R., & Schwarzer, D. (2008) · Angewandte Chemie · doi:10.1002/ange.200801313 · Cited by 220 · see citing works
Catalyst Morphology and Dissolution Kinetics of Self-Healing Polymers
Jones, A. S., Rule, J. D., Moore, J. S., White, S. R., & Sottos, N. R. (2006) · Chemistry of Materials · doi:10.1021/cm051864s · Cited by 210 · see citing works
Spontaneous Deracemizations
Buhse, T., Cruz, J.-M., Noble-Terán, M. E., Hochberg, D., Ribó, J. M., Crusats, J., & Micheau, J.-C. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00819 · Cited by 189 · see citing works
Chiral amplification of oligopeptides in two-dimensional crystalline self-assemblies on water
Zepik, H., Shavit, E., Tang, M., Jensen, T. R., Kjaer, K., Bolbach, G., Leiserowitz, L., Weissbuch, I., & Lahav, M. (2002) · Science · doi:10.1126/science.1065625 · Cited by 192 · see citing works
Possible chemical and physical scenarios towards biological homochirality
Sallembien, Q., Bouteiller, L., Crassous, J., & Raynal, M. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01179k · Cited by 186 · see citing works
Serine Octamers: Cluster Formation, Reactions, and Implications for Biomolecule Homochirality
Nanita, S. C., & Cooks, R. G. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200501328 · Cited by 184 · see citing works
Yield and Post-Yield Behavior of Mussel Byssal Thread: A Self-Healing Biomolecular Material
Vaccaro, E., & Waite, J. H. (2001) · Biomacromolecules · doi:10.1021/bm0100514 · Cited by 176 · see citing works
Chiral nanotechnology
Zhang, J., Albelda, M. T., Liu, Y., & Canary, J. W. (2005) · Chirality · doi:10.1002/chir.20178 · Cited by 175 · see citing works
Orthogonal Control of Dissociation Dynamics Relative to Thermodynamics in a Main-Chain Reversible Polymer
Yount, W. C., Juwarker, H., & Craig, S. L. (2003) · Journal of the American Chemical Society · doi:10.1021/ja036709y · Cited by 171 · see citing works
Programmed Self-Sorting of Coiled Coils with Leucine and Hexafluoroleucine Cores
Bilgiçer, B., Xing, X., & Kumar, K. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016767o · Cited by 169 · see citing works
Self‐Replicating Amphiphilic β‐Sheet Peptides
Rubinov, B., Wagner, N., Rapaport, H., & Ashkenasy, G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200902790 · Cited by 169 · see citing works
Fluorine in Peptide Design and Protein Engineering
Jäckel, C., & Koksch, B. (2005) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200500205 · Cited by 167 · see citing works
A chemically fuelled self-replicator
Morrow, S. M., Colomer, I., & Fletcher, S. P. (2019) · Nature Communications · doi:10.1038/s41467-019-08885-9 · Cited by 166 · see citing works
Self-Assembled Heterotrimeric Collagen Triple Helices Directed through Electrostatic Interactions
Gauba, V., & Hartgerink, J. D. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0683640 · Cited by 166 · see citing works
Chirality of living systems: a helping hand from crystals and oligopeptides.
Cintas, P. (2002) · Angewandte Chemie · doi:10.1002/1521-3773(20020402)41:7 · Cited by 120 · see citing works
Stochastic “Mirror Symmetry Breaking” via Self-Assembly, Reactivity and Amplification of Chirality: Relevance to Abiotic Conditions
Weissbuch, I., Leiserowitz, L., & Lahav, M. (2005) · Springer eBooks · doi:10.1007/b137067 · Cited by 155 · see citing works
Systems Chemistry: Kinetic and Computational Analysis of a Nearly Exponential Organic Replicator
Kindermann, M., Stahl, I., Reimold, M., Pankau, W. M., & von Kiedrowski, G. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501527 · Cited by 153 · see citing works
Fluorine in a Native Protein Environment—How the Spatial Demand and Polarity of Fluoroalkyl Groups Affect Protein Folding
Jäckel, C., Salwiczek, M., & Koksch, B. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200504387 · Cited by 146 · see citing works
Making Molecules Make Themselves – the Chemistry of Artificial Replicators
Vidonne, A., & Philp, D. (2008) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200800827 · Cited by 145 · see citing works
The Road to Non‐Enzymatic Molecular Networks
Dadon, Z., Wagner, N., & Ashkenasy, G. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200702552 · Cited by 141 · see citing works
On the Possible Amyloid Origin of Protein Folds
Greenwald, J., & Riek, R. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.04.015 · Cited by 138 · see citing works
Presidential Address to the Mineralogical Society of America, Salt Lake City, October 18, 2005: Mineral surfaces and the prebiotic selection and organization of biomolecules
Hazen, R. M. (2006) · American Mineralogist · doi:10.2138/am.2006.2289 · Cited by 134 · see citing works
Semiconductor Nanohelices Templated by Supramolecular Ribbons
Sone, E. D., Zubarev, E. R., & Stupp, S. I. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020517)41:10 · Cited by 275 · see citing works
Toward β-Peptide Tertiary Structure: Self-Association of an Amphiphilic 14-Helix in Aqueous Solution
Raguse, T. L., Lai, J. R., LePlae, P. R., & Gellman, S. H. (2001) · Organic Letters · doi:10.1021/ol016868r · Cited by 130 · see citing works
Phosphates, DNA, and the Search for Nonterrean Life: A Second Generation Model for Genetic Molecules
Benner, S. A., & Hutter, D. (2002) · Bioorganic Chemistry · doi:10.1006/bioo.2001.1232 · Cited by 128 · see citing works
“Belt and Braces”: A Peptide-Based Linker System of de Novo Design
Ryadnov, M. G., Ceyhan, B., Niemeyer, C. M., & Woolfson, D. N. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0352045 · Cited by 121 · see citing works
Asymmetric Photoreactions as the Origin of Biomolecular Homochirality: A Critical Review
Jorissen, A., & Cerf, C. (2002) · Origins of life and evolution of the biosphere · doi:10.1023/a:1016087202273 · Cited by 116 · see citing works
Achiral Nucleobase Cytosine Acts as an Origin of Homochirality of Biomolecules in Conjunction with Asymmetric Autocatalysis
Kawasaki, T., Suzuki, K., Hakoda, Y., & Soai, K. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200703634 · Cited by 115 · see citing works
Uncovering the Selection Criteria for the Emergence of Multi-Building-Block Replicators from Dynamic Combinatorial Libraries
Malakoutikhah, M., Peyralans, J. J.-P., Colomb-Delsuc, M., Fanlo-Virgós, H., Stuart, M. C. A., & Otto, S. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4067805 · Cited by 111 · see citing works
Chiral Self‐sorting of Giant Cubic [8+12] Salicylimine Cage Compounds
Wagner, P., Röminger, F., Zhang, W., Gross, J. H., Elbert, S. M., Schröder, R. R., & Mastalerz, M. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202016592 · Cited by 111 · see citing works
Systems Chemistry: Logic Gates, Arithmetic Units, and Network Motifs in Small Networks
Wagner, N., & Ashkenasy, G. (2008) · Chemistry - A European Journal · doi:10.1002/chem.200801850 · Cited by 109 · see citing works
Kinetic Evidence for a Tetrameric Transition State in the Asymmetric Autocatalytic Alkylation of Pyrimidyl Aldehydes
Buono, F. G., & Blackmond, D. G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034705n · Cited by 106 · see citing works
Resolution of Seven‐Coordinate Complexes
Lennartson, A., Vestergren, M., & Håkansson, M. (2005) · Chemistry - A European Journal · doi:10.1002/chem.200401019 · Cited by 101 · see citing works
The Role of Atmospheric Aerosols in the Origin Of Life
Tuck, A. (2002) · Surveys in Geophysics · doi:10.1023/a:1020123922767 · Cited by 99 · see citing works
Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligodipeptides and Oligodipeptoids Tagged with Triazines as Recognition Elements
Mittapalli, G. K., Reddy, K. R., Xiong, H., Munoz, O., Han, B., Riccardis, F. D., Krishnamurthy, R., & Eschenmoser, A. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200603207 · Cited by 98 · see citing works
Social Self-Sorting: Alternating Supramolecular Oligomer Consisting of Isomers
Tomimasu, N., Kanaya, A., Takashima, Y., Yamaguchi, H., & Harada, A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903988c · Cited by 96 · see citing works
Exploring the emergence of complexity using synthetic replicators
Kosikova, T., & Philp, D. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00123a · Cited by 93 · see citing works
Proximity-driven metallopeptide catalysis: Remarkable side-chain scope enables modification of the Fos bZip domain
Popp, B. V., & Ball, Z. T. (2011) · Chemical Science · doi:10.1039/c0sc00564a · Cited by 92 · see citing works
Covalent Capture: Merging Covalent and Noncovalent Synthesis
Prins, L. J., & Scrimin, P. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200803583 · Cited by 89 · see citing works
Structure and mechanical properties of artificial protein hydrogels assembled through aggregation of leucine zipper peptide domains
Shen, W. H., Kornfield, J. A., & Tirrell, D. A. (2006) · Soft Matter · doi:10.1039/b610986a · Cited by 87 · see citing works
Oligopeptide Foldamers: From Structure to Function
Licini, G., Prins, L. J., & Scrimin, P. (2005) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200400521 · Cited by 86 · see citing works
Self-organization vs. self-ordering events in life-origin models
Abel, D. L., & Trevors, J. T. (2006) · Physics of Life Reviews · doi:10.1016/j.plrev.2006.07.003 · Cited by 84 · see citing works
Site-Specific Protein Modification with a Dirhodium Metallopeptide Catalyst
Chen, Z., Popp, B. V., Bovet, C. L., & Ball, Z. T. (2011) · ACS Chemical Biology · doi:10.1021/cb2001523 · Cited by 84 · see citing works
Absolute asymmetric synthesis in enantioselective autocatalytic reaction networks: theoretical games, speculations on chemical evolution and perhaps a synthetic option
Ribó, J. M., Blanco, C., Crusats, J., El‐Hachemi, Z., Hochberg, D., & Moyano, A. (2014) · Chemistry – A European Journal · doi:10.1002/chem.201404534 · Cited by 81 · see citing works
A peptide template as an allosteric supramolecular catalyst for the cleavage of phosphate esters
Scarso, A., Scheffer, U., Göbel, M., Broxterman, Q. B., Kaptein, B., Formaggio, F., Toniolo, C., & Scrimin, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072642699 · Cited by 81 · see citing works
Emergence of native peptide sequences in prebiotic replication networks
Nanda, J., Rubinov, B., Ivnitski, D., Mukherjee, R., Shtelman, E., Motro, Y., Miller, Y., Wagner, N., Cohen‐Luria, R., & Ashkenasy, G. (2017) · Nature Communications · doi:10.1038/s41467-017-00463-1 · Cited by 76 · see citing works
Racemic β-Sheets as Templates of Relevance to the Origin of Homochirality of Peptides: Lessons from Crystal Chemistry
Weissbuch, I., Illos, R. A., Bolbach, G., & Lahav, M. (2009) · Accounts of Chemical Research · doi:10.1021/ar900033k · Cited by 78 · see citing works
Templated Ligand Assembly by Using G‐Quadruplex DNA and Dynamic Covalent Chemistry
Whitney, A. M., Ladame, S., & Balasubramanian, S. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200353069 · Cited by 79 · see citing works
Dynamic Covalent Chemistry on Self‐Templating Peptides: Formation of a Disulfide‐linked β‐Hairpin Mimic
Krishnan‐Ghosh, Y., & Balasubramanian, S. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200250551 · Cited by 79 · see citing works
Chain Stopper-Assisted Characterization of Supramolecular Polymers
Lortie, F., Boileau, S., Bouteiller, L., Chassenieux, C., & Laupretre, F. (2005) · Macromolecules · doi:10.1021/ma050168a · Cited by 76 · see citing works
Symmetry breaking and chiral amplification in prebiotic ligation reactions
Deng, M., Yu, J., & Blackmond, D. G. (2024) · Nature · doi:10.1038/s41586-024-07059-y · Cited by 79 · see citing works
A tentative kinetic model for chiral amplification in autocatalytic alkylzinc additions
Buhse, T. (2003) · Tetrahedron Asymmetry · doi:10.1016/s0957-4166(03)00128-9 · Cited by 75 · see citing works
Self‐Sorting of Dynamic Imine Libraries during Distillation
Osowska, K., & Miljanić, O. Š. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201102813 · Cited by 72 · see citing works
On the Role of Chirality in Guiding the Self‐Assembly of Peptides
Basak, S., Singh, I., Ferranco, A., Syed, J., & Kraatz, H. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706162 · Cited by 71 · see citing works
Mechanismen der Autokatalyse
Bissette, A. J., & Fletcher, S. P. (2013) · Angewandte Chemie · doi:10.1002/ange.201303822 · Cited by 71 · see citing works
Spontaneous mirror symmetry breaking and origin of biological homochirality
Ribó, J. M., Hochberg, D., Crusats, J., El-Hachemi, Z., & Moyano, A. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0699 · Cited by 68 · see citing works
Out‐of‐Equilibrium Self‐Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators
Liu, B., Wu, J., Geerts, M., Markovitch, O., Pappas, C. G., Liu, K., & Otto, S. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202117605 · Cited by 60 · see citing works
The design of self-replicating helical peptides
Issac, R. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00233-5 · Cited by 65 · see citing works
Emerging principles of de novo catalyst design
Baltzer, L., & Nilsson, J. (2001) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(00)00227-5 · Cited by 65 · see citing works
Self-Assembly of Left- and Right-Handed Molecular Screws
Xu, F., Khan, I. J., McGuinness, K. N., Parmar, A. S., Silva, T., Murthy, N. S., & Nanda, V. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4106545 · Cited by 64 · see citing works
Probing chiral interfaces by infrared spectroscopic methods
Bieri, M., Gautier, C., & Bürgi, T. (2006) · Physical Chemistry Chemical Physics · doi:10.1039/b609930k · Cited by 63 · see citing works
Guest Binding and Orientation within Open Nanoscale Hosts
Laughrey, Z. R., Gibb, C. L. D., Sénéchal, T., & Gibb, B. C. (2002) · Chemistry - A European Journal · doi:10.1002/chem.200390008 · Cited by 61 · see citing works
Biocatalytic and biomimetic aminolysis reactions: useful tools for selective transformations on polyfunctional substrates
Alfonso, I., & Gotor, V. (2004) · Chemical Society Reviews · doi:10.1039/b307785n · Cited by 61 · see citing works
Evaluation of the Molecular Interactions of Fluorinated Amino Acids with Native Polypeptides
Jäckel, C., Seufert, W., Thust, S., & Koksch, B. (2004) · ChemBioChem · doi:10.1002/cbic.200300840 · Cited by 58 · see citing works
Chiroptical Transcription of Helical Information through Supramolecular Harmonization with Dynamic Helices
Guo, Y.-M., Oike, H., & Aida, T. (2003) · Journal of the American Chemical Society · doi:10.1021/ja039369p · Cited by 58 · see citing works
The Origin and Early Evolution of Membrane Channels
Pohorille, A., Schweighofer, K. J., & Wilson, M. A. (2005) · Astrobiology · doi:10.1089/ast.2005.5.1 · Cited by 59 · see citing works
Small and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine
Wieczorek, R., Adamala, K., Gasperi, T., Polticelli, F., & Stano, P. (2017) · Life · doi:10.3390/life7020019 · Cited by 53 · see citing works
Absolute Asymmetric Synthesis of “Chiral‐at‐Metal” Grignard Reagents and Transfer of the Chirality to Carbon
Vestergren, M., Eriksson, J., & Håkansson, M. (2003) · Chemistry - A European Journal · doi:10.1002/chem.200305003 · Cited by 55 · see citing works
Peptide membranes in chemical evolution
Childers, W. S., Ni, R., Mehta, A. K., & Lynn, D. G. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.09.027 · Cited by 55 · see citing works
Light‐Induced Peptide Replication Controls Logic Operations in Small Networks
Dadon, Z., Samiappan, M., Yishay‐Safranchik, E., & Ashkenasy, G. (2010) · Chemistry - A European Journal · doi:10.1002/chem.201001488 · Cited by 55 · see citing works
Pentopyranosyl Oligonucleotide Systems. 9th Communication: The β ‐ <scp>D</scp> ‐Ribopyranosyl‐(4′→2′)‐oligonucleotide System (‘Pyranosyl‐RNA’): Synthesis and Resumé of Base‐Pairing Properties
Pitsch, S., Wendeborn, S., Krishnamurthy, R., Holzner, A., Minton, M., Bolli, M., Miculca, C., Windhab, N., Micura, R., Stanek, M., et al. (2003) · Helvetica Chimica Acta · doi:10.1002/hlca.200390349 · Cited by 55 · see citing works
Primordial Genetics: Phenotype of the Ribocyte
Yarus, M. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.031902.105056 · Cited by 55 · see citing works
A Fragment‐Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry
Scott, D. E., Dawes, G. J. S., Ando, M., Abell, C., & Ciulli, A. (2009) · ChemBioChem · doi:10.1002/cbic.200900537 · Cited by 54 · see citing works
Origin of life. Primordial genetics: Information transfer in a pre-RNA world based on self-replicating beta-sheet amyloid conformers
Maury, C. P. J. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.07.008 · Cited by 53 · see citing works

Kinetic Analysis of Self-Replicating Peptides: Possibility of Chiral Amplification in Open Systems
Rivera-Islas, J., Micheau, J. C., & Buhse, T. (2004) · Origins of Life and Evolution of Biospheres · doi:10.1023/b:orig.0000043115.95561.23 · Cited by 13 · see citing works
Cross-Catalysis between Self-Replicators of Different Handedness
Malakoutikhah, M., Schaeffer, G., Santiago, G. M., Yang, S., Marić, I., & Otto, S. (2019) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 1 · see citing works
Enantioselective Self-Replicators
Yang, S., Geiger, Y., Geerts, M., Eleveld, M., Kiani, A., & Otto, S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c05472 · Cited by 16 · see citing works
Homochirality and stereospecific activity: evolutionary aspects
Avetisov, V. V., & Gol'danskiĭ, V. I. (1991) · Biosystems · doi:10.1016/0303-2647(91)90002-3 · Cited by 22 · see citing works
Constraints on the Origin of Biological Homochirality: From Left-Handed Life to Replication Efficiency as a Function of Enantiomeric ExcessPreprint
Geil, M. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.18745590

Authors: Saghatelian, A., Yokobayashi, Y., Soltani, K., & Ghadiri, M. R.
Affiliations: Scripps Research Institute (US)
Corresponding author: Ghadiri, M. Reza
ORCID: Saghatelian, Alan
Yokobayashi, Yohei
Ghadiri, M. Reza
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-02-15
Volume: 409
Issue: 6822
Pages: 797-801
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35057238
OpenAlex: W2130128712
Cited by: 310
References: 70
Citations by year: 2026: 7 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 11 · 2018: 5 · 2017: 13 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 11 · 2012: 13
FWCI: 14.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: NASA Astrobiology Institute
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
Keywords: homochirality, origin of life, autocatalysis, prebiotic chemistry
MeSH terms: Amino Acid Sequence, Catalysis, Molecular Sequence Data, Mutation, Peptide Fragments, Peptide Biosynthesis, Peptides, Protein Conformation, Stereoisomerism, Thermodynamics, Evolution, Chemical

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A chiroselective peptide replicator

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