Meakin, Paul J.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature

Genomics, phytochemicals, and oxidative stressImmune cells in cancer

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Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

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The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis

Deldicque, L., Cani, P. D., Philp, A., Raymackers, J.-M., Meakin, P. J., Ashford, M. L. J., Delzenne, N. M., Francaux, M., & Baar, K. (2010) · American Journal of Physiology-Endocrinology and Metabolism

Endoplasmic Reticulum Stress and DiseaseMuscle metabolism and nutrition

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BACE1: More than just a β‐secretase

Taylor, H. A., Przemylska, L., Clavane, E. M., & Meakin, P. J. (2022) · Obesity Reviews

Adipokines, Inflammation, and Metabolic DiseasesAlzheimer's disease research and treatments

Cited by 107

Phosphoinositide 3-Kinases Upregulate System x c − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M.-A., Halatsch, M.-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., et al. (2014) · Antioxidants & Redox Signaling

Amino Acid Enzymes and MetabolismPI3K/AKT/mTOR signaling in cancer

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Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

Deighton, R. F., Márkus, N. M., Al-Mubarak, B., Bell, K. F. S., Papadia, S., Meakin, P. J., Chowdhry, S., Hayes, J. D., & Hardingham, G. E. (2014) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressNuclear Receptors and Signaling

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