Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

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Neuronal activity regulates astrocytic Nrf2 signaling

Habas, A., Hahn, J., Wang, X., & Margeta, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208764110 · Cited by 97 · see citing works

Phosphoinositide 3-Kinases Upregulate System x _c ⁻ <i>via</i> Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M.-A., Halatsch, M.-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., et al. (2014) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5455 · Cited by 66 · see citing works

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

López-Fabuel, I., Douce, J. L., Logan, A., James, A. M., Bonvento, G., Murphy, M. P., Almeida, Á., & Bolaños, J. P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613701113 · Cited by 474 · see citing works

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

Hasel, P., Dando, O., Jiwaji, Z., Baxter, P. S., Todd, A., Heron, S., Márkus, N. M., McQueen, J., Hampton, D. W., Torvell, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15132 · Cited by 305 · see citing works

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works

Bioenergetics and redox adaptations of astrocytes to neuronal activity

Bolaños, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13486 · Cited by 262 · see citing works

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

Baxter, P. S., & Hardingham, G. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.027 · Cited by 235 · see citing works

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

Jimenez-Blasco, D., Santofimia-Castaño, P., Gonzalez, A., Almeida, A., & Bolaños, J. P. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2015.49 · Cited by 196 · see citing works

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8066 · Cited by 191 · see citing works

Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?

Liddell, J. R. (2017) · Antioxidants · doi:10.3390/antiox6030065 · Cited by 167 · see citing works

Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation

Almeida, Á., Jiménez-Blasco, D., & Bolaños, J. P. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220075 · Cited by 115 · see citing works

The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention

Boas, S. M., Joyce, K. L., & Cowell, R. M. (2021) · Antioxidants · doi:10.3390/antiox11010008 · Cited by 69 · see citing works

Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease

Jiwaji, Z., & Hardingham, G. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.020 · Cited by 51 · see citing works

Multitarget Effects of Nrf2 Signalling in the Brain: Common and Specific Functions in Different Cell Types

Navarro, E., & Esteras, N. (2024) · Antioxidants · doi:10.3390/antiox13121502 · Cited by 47 · see citing works

Comparison of human Nrf2 antibodies: A tale of two proteins

Kemmerer, Z. A., Ader, N. R., Mulroy, S. S., & Eggler, A. L. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.07.004 · Cited by 41 · see citing works

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

Al-Mubarak, B. R., Bell, K. F. S., Chowdhry, S., Meakin, P. J., Baxter, P. S., McKay, S., Dando, O., Ashford, M. L. J., Gazaryan, I. G., Hayes, J. D., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102158 · Cited by 39 · see citing works

A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy

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Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy

Sandouka, S., Saadi, A., Singh, P. K., Taiwo, R. O., & Shekh‐Ahmad, T. (2023) · Cell & Bioscience · doi:10.1186/s13578-022-00951-y · Cited by 36 · see citing works

Intertwined ROS and Metabolic Signaling at the Neuron-Astrocyte Interface

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Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation

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Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration

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Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

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Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage

Loan, J. J., Salman, R. A., McColl, B. W., & Hardingham, G. E. (2022) · Biomolecules · doi:10.3390/biom12101438 · Cited by 17 · see citing works

Neuronal Activity and Its Role in Controlling Antioxidant Genes

Qiu, J., Dando, O., Febery, J. A., Fowler, J. H., Chandran, S., & Hardingham, G. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061933 · Cited by 17 · see citing works

Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics

Tena‐Morraja, P., Riqué‐Pujol, G., Müller‐Sánchez, C., Reina, M., Martínez-Estrada, O. M., & Soriano, F. X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020922 · Cited by 11 · see citing works

Nrf2 controls homeostatic transcriptional signatures and inflammatory responses in a cell-type specific manner in the adult mouse brain

He, X., Dando, O., & Qiu, J. (2025) · iScience · doi:10.1016/j.isci.2025.113198 · Cited by 9 · see citing works

Comparative subcellular localization of NRF2 and KEAP1 during the hepatocellular carcinoma development in vivo

Guerrero‐Escalera, D., Alarcón‐Sánchez, B. R., Arellanes‐Robledo, J., Cruz‐Rangel, A., del Pozo‐Yauner, L., de Sánchez, V. C., Reséndis-Antonio, O., Villa‐Treviño, S., Torres‐Mena, J. E., & Pérez‐Carreón, J. I. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119222 · Cited by 9 · see citing works

General anesthesia alters CNS and astrocyte expression of activity-dependent and activity-independent genes

Jiwaji, Z., Márkus, N. M., McQueen, J., Emelianova, K., He, X., Dando, O., Chandran, S., & Hardingham, G. E. (2023) · Frontiers in Network Physiology · doi:10.3389/fnetp.2023.1216366 · Cited by 5 · see citing works

The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2

Feng, J., Carreño, M., Jung, H., Naidu, S. D., Arroyo-Díaz, N. M., Ang, A. D., Kulkarni, B., Kisielewski, D., Suzuki, T., Yamamoto, M. P., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104009 · Cited by 4 · see citing works

Reply to Deighton et al.: Neuronal activity regulates distinct antioxidant pathways in neurons and astrocytes

Habas, A., Hahn, J., Wang, X., & Margeta, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403291111 · Cited by 2 · see citing works

Transcriptional and functional consequences of neuron-astrocyte interactions

Jiwaji, Z. (2019) · ERA

Additional file 1 of Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy

Sandouka, S., Saadi, A., Singh, P. K., Taiwo, R. O., & Shekh‐Ahmad, T. (2023) · Figshare · doi:10.6084/m9.figshare.22607986

Reply to Deighton et al.: Neuronal activity regulates distinct antioxidant pathways in neurons and astrocytes

Habas, A., Hahn, J., Wang, X., & Margeta, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403291111 · Cited by 2 · see citing works

Neuronal activity regulates astrocytic Nrf2 signaling

Habas, A., Hahn, J., Wang, X., & Margeta, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208764110 · Cited by 97 · see citing works

Neuronal activity regulates astrocytic Nrf2 signaling. - eScholarship

Habas, A., Hahn, J., Wang, X., & Margeta, M. (2013)

Neuronal Activity and Its Role in Controlling Antioxidant Genes

Qiu, J., Dando, O., Febery, J. A., Fowler, J. H., Chandran, S., & Hardingham, G. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061933 · Cited by 17 · see citing works

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

Al-Mubarak, B. R., Bell, K. F. S., Chowdhry, S., Meakin, P. J., Baxter, P. S., McKay, S., Dando, O., Ashford, M. L. J., Gazaryan, I. G., Hayes, J. D., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102158 · Cited by 39 · see citing works