Dennis, Patrick B.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 2,230

Mammalian TOR: a homeostatic ATP sensor

Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., & Thomas, G. (2001) · Science

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 962

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

Jefferies, H. B. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997) · The EMBO Journal

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 934

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 889

Phosphorylation and Activation of p70 s6k by PDK1

Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 826

The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

Pearson, R. B., Dennis, P. B., Han, J. W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E., & Thomas, G. (1995) · The EMBO Journal

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 443

Random heteropolymers preserve protein function in foreign environments

Panganiban, B., Qiao, B., Jiang, T., DelRe, C., Obadia, M. M., Nguyen, T. D., Smith, A. A. A., Hall, A., Sit, I., Crosby, M. G., et al. (2018) · Science

Protein Structure and Dynamicsbiodegradable polymer synthesis and properties

Cited by 294

AlphaFold2 models indicate that protein sequence determines both structure and dynamics

Guo, H.-B., Perminov, A., Bekele, S., Kedziora, G., Farajollahi, S., Varaljay, V., Hinkle, K., Molinero, V., Meister, K., Hung, C., et al. (2022) · Scientific Reports

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 248

AlphaFold2 models indicate that protein sequence determines both structure and dynamics

Guo, H.-B., Perminov, A., Bekele, S., Kedziora, G., Farajollahi, S., Varaljay, V., Hinkle, K., Molinero, V., Meister, K., Hung, C., et al. (2022) · Scientific Reports

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 248

Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization

Mercer, C. A., Kaliappan, A., & Dennis, P. B. (2008) · Autophagy

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 19

AlphaFold2 modeling and molecular dynamics simulations of an intrinsically disordered protein

Guo, H.-B., Huntington, B., Perminov, A., Smith, K., Hastings, N., Dennis, P., Kelley-Loughnane, N., & Berry, R. (2024) · PLOS ONE

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 13

AlphaFold2 modeling and molecular dynamics simulations of an intrinsically disordered protein

Guo, H.-B., Huntington, B., Perminov, A., Smith, K., Hastings, N., Dennis, P., Kelley-Loughnane, N., & Berry, R. (2023) · PLoS ONE

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 13