Thériault, Sébastien

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Program, T. M. V., Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyBlood Pressure and Hypertension Studies

Cited by 1,381

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

Thériault, S., Gaudreault, N., Lamontagne, M., Rosa, M., Boulanger, M.-C., Messika-Zeitoun, D., Clavel, M.-A., Capoulade, R., Dagenais, F., Pibarot, P., et al. (2018) · Nature Communications

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 135

Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia

Paquette, M., Chong, M., Thériault, S., Dufour, R., Paré, G., & Baass, A. (2017) · Journal of Clinical Lipidology

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 115

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis

Perrot, N., Valerio, V., Moschetta, D., Boekholdt, S. M., Dina, C., Chen, H. Y., Abner, E., Martinsson, A., Manikpurage, H. D., Rigade, S., et al. (2020) · JACC: Basic to Translational Science

Cardiac Valve Diseases and TreatmentsDermatological and Skeletal Disorders

Cited by 91

Genetic Association Analyses Highlight IL6 , ALPL , and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis

Thériault, S., Dina, C., Messika-Zeitoun, D., Le Scouarnec, S., Capoulade, R., Gaudreault, N., Rigade, S., Li, Z., Simonet, F., Lamontagne, M., et al. (2019) · Circulation: Genomic and Precision Medicine

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 90

Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression: A Systematic Review and Meta-Analysis

Arsenault, B. J., Loganath, K., Girard, A., Botezatu, S., Zheng, K. H., Tzolos, E., Abdoun, K., Tastet, L., Capoulade, R., Côté, N., et al. (2024) · JAMA Cardiology

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 80

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis

Chen, H. Y., Cairns, B. J., Small, A. M., Burr, H. A., Ambikkumar, A., Martinsson, A., Thériault, S., Munter, H. M., Steffen, B., Zhang, R., et al. (2020) · JAMA Cardiology

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 65

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Thériault, S., Li, Z., Abner, E., Luan, J., Manikpurage, H. D., Houessou, U., Zamani, P., Briend, M., Estonian Biobank Research Team, Boudreau, D. K., et al. (2024) · Nature Communications

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 49

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J.-W., et al. (2022) · Nature Communications

Cardiac electrophysiology and arrhythmiasGenetic Associations and Epidemiology

Cited by 49

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis

Li, Z., Gaudreault, N., Arsenault, B. J., Mathieu, P., Bossé, Y., & Thériault, S. (2020) · Communications Biology

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 23

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Small, A. M., Yang, T.-Y., Itoh, S., Thériault, S., Dufresne, L., Kurosawa, R., Komuro, I., Matsuda, K., Vy, H. M. T., Farber-Eger, E. H., et al. (2026) · Nature Genetics

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 18

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis

Chignon, A., Rosa, M., Boulanger, M.-C., Argaud, D., Devillers, R., Bon-Baret, V., Mkannez, G., Li, Z., Rufiange, A., Gaudreault, N., et al. (2021) · iScience

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 18

Impact of loss-of-function in angiopoietin-like 4 on the human phenome

Gagnon, E., Bourgault, J., Gobeil, É., Thériault, S., & Arsenault, B. J. (2024) · Atherosclerosis

Lipid metabolism and disordersGenetic Associations and Epidemiology

Cited by 17

Transcriptomic signatures of calcific aortic valve stenosis severity in human tricuspid and bicuspid aortic valves

Houessou, U., Zamani, P., Manikpurage, H. D., Li, Z., Gaudreault, N., Dahmene, M., Dagenais, F., Couture, C., Clavel, M.-A., Pibarot, P., et al. (2025) · JACC: Basic to Translational Science

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 11

A transcriptomic approach to sex differences in calcific aortic valve stenosis in patients with a tricuspid aortic valve

Le Nezet, E., Tam, R., Li, Z., Gaudreault, N., Mathieu, P., Côté, N., Guisle, I., Thériault, S., Bossé, Y., & Clavel, M.-A. (2025) · CJC Open

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 5

Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets

Zamani, P., Houessou, U., Manikpurage, H. D., Li, Z., Dahmene, M., Gaudreault, N., Dagenais, F., Clavel, M.-A., Pibarot, P., Arsenault, B. J., et al. (2025) · Human Genetics and Genomics Advances

Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment Approaches

Cited by 3

Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues

Houessou, U., Zamani, P., Manikpurage, H. D., Li, Z., Gaudreault, N., Dahmene, M., Dagenais, F., Couture, C., Clavel, M.-A., Pibarot, P., et al. (2026) · Atherosclerosis

Cardiac Valve Diseases and TreatmentsGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 1

CONTEXT-DEPENDENT AORTIC VALVE EQTLS HIGHLIGHT POTENTIAL CAUSAL DRIVERS OF AORTIC VALVE STENOSIS

Zamani, P., Houessou, U., Li, Z., Gaudreault, N., Bossé, Y., & Thériault, S. (2026) · Atherosclerosis

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 0

Connecting proteomics and genomics to identify causal biomarkers specific for aortic valve stenosis

Zamani, P., Houessou, U., Manikpurage, H. D., Dahmene, M., Li, Z., Gaudreault, N., Clavel, M.-A., Pibarot, P., Mathieu, P., Arsenault, B. J., et al. (2025) · medRxiv

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 0