Mazitschek, Ralph

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature

Histone Deacetylase Inhibitors ResearchMemory and Neural Mechanisms

Cited by 1,644

Treatment of Obesity with Celastrol

Liu, J., Lee, J., Salazar Hernandez, M. A., Mazitschek, R., & Ozcan, U. (2015) · Cell

Regulation of Appetite and ObesityPharmacology and Obesity Treatment

Cited by 726

Chemical phylogenetics of histone deacetylases

Bradner, J. E., West, N., Grachan, M. L., Greenberg, E. F., Haggarty, S. J., Warnow, T., & Mazitschek, R. (2010) · Nature Chemical Biology

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 720

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

Santo, L., Hideshima, T., Kung, A. L., Tseng, J.-C., Tamang, D., Yang, M., Jarpe, M., van Duzer, J. H., Mazitschek, R., Ogier, W. C., et al. (2012) · Blood

Multiple Myeloma Research and TreatmentsHistone Deacetylase Inhibitors Research

Cited by 616

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

Kim, D., Frank, C. L., Dobbin, M. M., Tsunemoto, R. K., Tu, W., Peng, P. L., Guan, J.-S., Lee, B.-H., Moy, L. Y., Giusti, P., et al. (2008) · Neuron

Histone Deacetylase Inhibitors ResearchCancer-related Molecular Pathways

Cited by 286

HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions

Tran, A. D.-A., Marmo, T. P., Salam, A. A., Che, S., Finkelstein, E., Kabarriti, R., Xenias, H. S., Mazitschek, R., Hubbert, C., Kawaguchi, Y., et al. (2007) · Journal of Cell Science

Histone Deacetylase Inhibitors ResearchMicrotubule and mitosis dynamics

Cited by 281

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Bradner, J. E., Mak, R., Tanguturi, S. K., Mazitschek, R., Haggarty, S. J., Ross, K., Chang, C. Y., Bosco, J., West, N., Morse, E., et al. (2010) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersHistone Deacetylase Inhibitors Research

Cited by 211

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

Minami, J., Suzuki, R., Mazitschek, R., Gorgun, G., Ghosh, B., Cirstea, D., Hu, Y., Mimura, N., Ohguchi, H., Cottini, F., et al. (2014) · Leukemia

Histone Deacetylase Inhibitors ResearchMultiple Myeloma Research and Treatments

Cited by 159

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

McLellan, C. A., Whitesell, L., King, O. D., Lancaster, A. K., Mazitschek, R., & Lindquist, S. (2012) · ACS Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 115

Lymphocyte Chemotaxis Is Regulated by Histone Deacetylase 6, Independently of Its Deacetylase Activity

Cabrero, J. R., Serrador, J. M., Barreiro, O., Mittelbrunn, M., Naranjo-Suárez, S., Martín-Cófreces, N., Vicente-Manzanares, M., Mazitschek, R., Bradner, J. E., Ávila, J., et al. (2006) · Molecular Biology of the Cell

Histone Deacetylase Inhibitors ResearchChemokine receptors and signaling

Cited by 95

HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications

Harada, T., Ohguchi, H., Grondin, Y., Kikuchi, S., Sagawa, M., Tai, Y.-T., Mazitschek, R., Hideshima, T., & Anderson, K. C. (2017) · Leukemia

Histone Deacetylase Inhibitors ResearchMultiple Myeloma Research and Treatments

Cited by 89

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Yeo, M. J. R., Zhang, O., Xie, X., Nam, E., Payne, N. C., Gosavi, P. M., Kwok, H. S., Iram, I., Lee, C., Li, J., et al. (2025) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 58

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

Xie, X., Zhang, O., Yeo, M. J. R., Lee, C., Tao, R., Harry, S. A., Payne, N. C., Nam, E., Paul, L., Li, Y., et al. (2025) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 50

A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader

Payne, N. C., Maksoud, S., Tannous, B. A., & Mazitschek, R. (2022) · Cell Chemical Biology

Protein Degradation and InhibitorsAdvanced Fluorescence Microscopy Techniques

Cited by 44

Tubacin Kills Epstein-Barr Virus (EBV)-Burkitt Lymphoma Cells by Inducing Reactive Oxygen Species and EBV Lymphoblastoid Cells by Inducing Apoptosis

Kawada, J., Zou, P., Mazitschek, R., Bradner, J. E., & Cohen, J. I. (2009) · Journal of Biological Chemistry

Viral-associated cancers and disordersHistone Deacetylase Inhibitors Research

Cited by 43

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

Zhao, W.-N., Ghosh, B., Tyler, M., Lalonde, J., Joseph, N. F., Kosaric, N., Fass, D. M., Tsai, L.-H., Mazitschek, R., & Haggarty, S. J. (2018) · ACS Chemical Neuroscience

Histone Deacetylase Inhibitors ResearchNeuroscience and Neuropharmacology Research

Cited by 35