Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity
Open accessAbstract
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in various neurodegenerative conditions. However, their underlying mechanisms are poorly understood. Here, we show that deregulation of histone deacetylase 1 (HDAC1) activity by p25/Cdk5 induces aberrant cell-cycle activity and double-strand DNA breaks leading to neurotoxicity. In a transgenic model for neurodegeneration, p25/Cdk5 activity elicited cell-cycle activity and double-strand DNA breaks that preceded neuronal death. Inhibition of HDAC1 activity by p25/Cdk5 was identified as an underlying mechanism for these events, and HDAC1 gain of function provided potent protection against DNA damage and neurotoxicity in cultured neurons and an in vivo model for ischemia. Our findings outline a pathological signaling pathway illustrating the importance of maintaining HDAC1 activity in the adult neuron. This pathway constitutes a molecular link between aberrant cell-cycle activity and DNA damage and is a potential target for therapeutics against diseases and conditions involving neuronal death.
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Deregulation of HDAC1 induces alteration in cell cycle activity and DNA damage leading to neuronal death in cultured neurons and mouse brain.
“Deregulation of HDAC1 induces alteration in cell cycle activity and DNA damage leading to neuronal death in cultured neurons and mouse brain [127].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [127]
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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · see citing works
Histone deacetylases (HDACs): characterization of the classical HDAC family
RUIJTER, A. J. M. D., GENNIP, A. H. V., CARON, H. N., KEMP, S., & KUILENBURG, A. B. P. V. (2003) · Biochemical Journal · doi:10.1042/bj20021321 · Cited by 3,114 · see citing works
Gene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works
Dent, S., Denu, J. M., & Allis, C. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.81 · Cited by 1,844 · see citing works
A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p
Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science · doi:10.1126/science.272.5260.408 · Cited by 1,829 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Self-citationConversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
Patrick, G. N., Zukerberg, L. R., Nikolić, M., de la Monte, S. M., Dikkes, P., & Tsai, L. (1999) · Nature · doi:10.1038/45159 · Cited by 1,541 · see citing works
Self-citationRetinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., & Kouzarides, T. (1998) · Nature · doi:10.1038/35404 · Cited by 1,231 · see citing works
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y.-Z., Greenwald, M., et al. (2001) · Nature · doi:10.1038/35099568 · Cited by 1,228 · see citing works
Recovery of learning and memory is associated with chromatin remodelling
Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227 · see citing works
Self-citationRegulation of histone acetylation during memory formation in the hippocampus
Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131 · see citing works
Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works
Self-citationNeurotoxicity induces cleavage of p35 to p25 by calpain
Lee, M.-S., Kwon, Y. T., Li, M., Peng, J., Friedlander, R. M., & Tsai, L. (2000) · Nature · doi:10.1038/35012636 · Cited by 1,057 · see citing works
Self-citationDhavan, R., & Tsai, L. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096019 · Cited by 1,052 · see citing works
Self-citationHockly, E., Richon, V. M., Woodman, B., Smith, D. L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi‐Noori, S., Mahal, A., Lowden, P. A. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437870100 · Cited by 847 · see citing works
Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 828 · see citing works
Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis
Ferrante, R. J., Browne, S. E., Shinobu, L. A., Bowling, A. C., Baik, M. J., MacGarvey, U. M., Kowall, N. W., Brown, R. H., & Beal, M. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052064.x · Cited by 808 · see citing works
Does oxidative damage to DNA increase with age?
Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., & Richardson, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171202698 · Cited by 768 · see citing works
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
Lagger, G., O'Carroll, D., Rembold, M., Khier, H., Tischler, J., Weitzer, G., Schuettengruber, B., Hauser, C., Brunmeir, R., Jenuwein, T., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2672 · Cited by 760 · see citing works
Cruz, J. C., Tseng, H.-C., Goldman, J. A., Shih, H., & Tsai, L.-H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00627-5 · Cited by 609 · see citing works
Self-citationDNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease
Yang, Y., Geldmacher, D., & Herrup, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02661.2001 · Cited by 607 · see citing works
The harlequin mouse mutation downregulates apoptosis-inducing factor
Klein, J. A., Longo-Guess, C. M., Rossmann, M. P., Seburn, K. L., Hurd, R. E., Frankel, W. N., Bronson, R. T., & Ackerman, S. L. (2002) · Nature · doi:10.1038/nature01034 · Cited by 605 · see citing works
Stipe, J., White, D., & Arsdale, E. V. (1979) · AJN American Journal of Nursing · doi:10.2307/3424618 · Cited by 602 · see citing works
Gui, C., Ngo, L., Xu, W., Richon, V. M., & Marks, P. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307708100 · Cited by 550 · see citing works
Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain
Busser, J., Geldmacher, D. S., & Herrup, K. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02801.1998 · Cited by 543 · see citing works
Mitotic mechanisms in Alzheimer's disease?
Vincent, I., Rosado, M., & Davies, P. (1996) · The Journal of cell biology · doi:10.1083/jcb.132.3.413 · Cited by 386 · see citing works
Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage
Kruman, I. I., Wersto, R. P., Cardozo‐Pelaez, F., Smilenov, L. B., Chan, S. L., Chrest, F. J., Emokpae, R., Gorospe, M., & Mattson, M. P. (2004) · Neuron · doi:10.1016/s0896-6273(04)00017-0 · Cited by 365 · see citing works
Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
Hu, E., Dul, E., Sung, C.-M., Chen, Z., Kirkpatrick, R. B., Zhang, G., Johanson, K., Liu, R., Lago, A. M., Hofmann, G. A., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.055541 · Cited by 350 · see citing works
Deregulation of Cdk5 in a Mouse Model of ALS
Nguyen, M. D., Larivière, R., & Julien, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00268-9 · Cited by 339 · see citing works
Smith, P. D., Crocker, S. J., Jackson-Lewis, V. R., Jordan‐Sciutto, K. L., Hayley, S. P., Mount, M. P., O'Hare, M. J., Callaghan, S. M., Slack, R. S., Przedborski, S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232515100 · Cited by 310 · see citing works
Rayman, J. B., Takahashi, Y., Indjeian, V. B., Dannenberg, J.-H., Catchpole, S., Watson, R. J., te Riele, H., & Dynlacht, B. D. (2002) · Genes & Development · doi:10.1101/gad.969202 · Cited by 288 · see citing works
Gojo, I., Jiemjit, A., Trepel, J. B., Sparreboom, A., Figg, W. D., Rollins, S., Tidwell, M. L., Greer, J. M., Chung, E. J., Lee, M.-J., et al. (2006) · Blood · doi:10.1182/blood-2006-05-021873 · Cited by 281 · see citing works
Fischer, A., Sananbenesi, F., Pang, P. T., Lu, B., & Tsai, L.-H. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.033 · Cited by 277 · see citing works
Self-citationCdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
Wang, J., Liu, S., Fu, Y., Wang, J. H.-C., & Lu, Y. (2003) · Nature Neuroscience · doi:10.1038/nn1119 · Cited by 270 · see citing works
Self-citationBates, G. P., Murphy, K., Harper, P. S., & Jones, L. A. (2002) · Cited by 263 · see citing works
Histone Deacetylase 1 Phosphorylation Promotes Enzymatic Activity and Complex Formation
Pflum, M. K. H., Tong, J. K., Lane, W. S., & Schreiber, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105590200 · Cited by 253 · see citing works
Histone deacetylase inhibitors reduce polyglutamine toxicity
McCampbell, A., Taye, A. A., Whitty, L., Penney, E. B., Steffan, J. S., & Fischbeck, K. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261400698 · Cited by 239 · see citing works
Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis
Padmanabhan, J., Park, D. S., Greene, L. A., & Shelanski, M. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08747.1999 · Cited by 233 · see citing works
The induction of multiple cell cycle events precedes target-related neuronal death
Herrup, K., & Busser, J. C. (1995) · Development · doi:10.1242/dev.121.8.2385 · Cited by 220 · see citing works
Yamaguchi, M., Tonou‐Fujimori, N., Komori, A., Maeda, R., Nojima, Y., Li, H., Okamoto, H., & Masai, I. (2005) · Development · doi:10.1242/dev.01881 · Cited by 207 · see citing works
Langley, B. C., Gensert, J. M., Beal, M. F., & Ratan, R. R. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005091 · Cited by 169 · see citing works
Linking DNA damage and neurodegeneration
Rolig, R. L., & McKinnon, P. J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01625-8 · Cited by 167 · see citing works
DNA strand breaks in Alzheimer’s disease
Adamec, E., Vonsattel, J. P., & Nixon, R. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02004-1 · Cited by 167 · see citing works
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
Wen, Y., Yang, S.-H., Liu, R., Perez, E. J., Brun-Zinkernagel, A. M., Koulen, P., & Simpkins, J. W. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.011 · Cited by 162 · see citing works
Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain
SWATTON, J. E., Sellers, L. A., Faull, R. L. M., Holland, A. J., Iritani, S., & Bahn, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03365.x · Cited by 158 · see citing works
Galasinski, S. C., Resing, K. A., Goodrich, J. A., & Ahn, N. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201174200 · Cited by 157 · see citing works
Gobbel, G. T., Bellinzona, M., Vogt, A. R., Gupta, N. M., Fike, J. R., & Chan, P. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00147.1998 · Cited by 148 · see citing works
Al‐Ubaidi, M. R., Hollyfield, J. G., Overbeek, P. A., & Baehr, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1194 · Cited by 148 · see citing works
Regulation of Neuronal Survival and Death by E2F-Dependent Gene Repression and Derepression
Liu, D. X., & Greene, L. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00495-0 · Cited by 132 · see citing works
O'Hare, M. J., Kushwaha, N., Zhang, Y., Aleyasin, H., Callaghan, S. M., Slack, R. S., Albert, P. R., Vincent, I. J., & Park, D. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2899-05.2005 · Cited by 125 · see citing works
Neuronal apoptosis induced by histone deacetylase inhibitors
Salminen, A., Tapiola, T., Korhonen, P., & Suuronen, T. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00210-1 · Cited by 109 · see citing works
Neuroprotection by histone deacetylase-related protein
Morrison, B. E., Majdzadeh, N., Zhang, X., Lyles, A., Bassel-Duby, R., Olson, E. N., & D'Mello, S. R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3550-3564.2006 · Cited by 100 · see citing works
Konishi, Y., & Bonni, A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01649.2003 · Cited by 97 · see citing works
Boutillier, A., Trinh, E., & Loeffler, J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01581.x · Cited by 94 · see citing works
Cell cycle machinery and stroke
Rashidian, J., Iyirhiaro, G. O., & Park, D. S. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.11.009 · Cited by 94 · see citing works
Stiegler, P., Luca, A. D., Bagella, L., et al. (1998) · PubMed · Cited by 91 · see citing works
Regulation of neuron survival and death by p130 and associated chromatin modifiersPreprint
Liu, D. X., Nath, N., Chellappan, S., & Greene, L. A. (2005) · Genes & Development · doi:10.1101/gad.1296405 · Cited by 77 · see citing works
When parsimony backfires: Neglecting DNA repair may doom neurons in Alzheimer's disease
Nouspikel, T., & Hanawalt, P. C. (2003) · BioEssays · doi:10.1002/bies.10227 · Cited by 68 · see citing works
Becker, C. G., & Becker, T. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001120)427:3 · Cited by 61 · see citing works
Oxidative damage and breakage of DNA in rat brain after transient MCA occlusion
Hayashi, T., Sakurai, M., Itoyama, Y., & Abe, K. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01409-2 · Cited by 58 · see citing works
Histone Deacetylation as a Target for Radiosensitization
Cerna, D., Camphausen, K. A., & Tofilon, P. J. (2006) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)73006-4 · Cited by 56 · see citing works
Kim, H., Kim, E., Kim, N., Chang, K., Choi, Y., Ahn, K., Lee, J., Kim, S., Park, C. H., & Suh, Y. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10845 · Cited by 56 · see citing works
DNA damage and chronic neuronal degenerations
Robison, S. H., & Bradley, W. G. (1984) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(84)90051-0 · Cited by 52 · see citing works
Citrome, L. (2003) · PubMed · Cited by 49 · see citing works
Mitsios, N., Pennucci, R., Krupiński, J., Sanfeliu, C., Gaffney, J. J., Kumar, P., Kumar, S., Juan‐Babot, O., & SLEVIN, M. A. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00031.x · Cited by 45 · see citing works
Hayashi, T., Sakai, K., Sasaki, C., Zhang, W. R., & Abe, K. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.00264.x · Cited by 33 · see citing works
Boutillier, A., Trinh, E., & Loeffler, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04679.x · Cited by 28 · see citing works
Bates, G. P. (2001) · Nature · doi:10.1038/35099656 · Cited by 17 · see citing works
García‐Bonilla, L., Bürda, J., Piñeiro, D., Ayuso, M. I., Gómez-Calcerrada, M., & Salinas, M. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9195-7 · Cited by 13 · see citing works
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HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works
Self-citationHistone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Falkenberg, K. J., & Johnstone, R. W. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4360 · Cited by 1,564 · see citing works
Ketone bodies as signaling metabolites
Newman, J. C., & Verdin, E. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.002 · Cited by 966 · see citing works
Morris, M., Maeda, S., Vossel, K., & Mucke, L. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.009 · Cited by 899 · see citing works
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Mathys, H., Adaikkan, C., Gao, F., Young, J. Z., Manet, E., Hemberg, M., De Jager, P. L., Ransohoff, R. M., Regev, A., & Tsai, L.-H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.039 · Cited by 740 · see citing works
Self-citationActivity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P.-C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.032 · Cited by 700 · see citing works
Self-citationMultiple roles of HDAC inhibition in neurodegenerative conditions
Chuang, D.-M., Leng, Y., Marinova, Z., Kim, H.-J., & Chiu, C.-T. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.002 · Cited by 676 · see citing works
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Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680 · see citing works
Self-citationDNA damage and its links to neurodegeneration
Madabhushi, R., Pan, L., & Tsai, L.-H. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.034 · Cited by 654 · see citing works
Self-citationThe road to restoring neural circuits for the treatment of Alzheimer's disease
Canter, R. G., Penney, J., & Tsai, L.-H. (2016) · Nature · doi:10.1038/nature20412 · Cited by 565 · see citing works
Self-citationSuberbielle, E., Sanchez, P. E., Kravitz, A. V., Wang, X., Ho, K., Eilertson, K., Devidze, N., Kreitzer, A. C., & Mucke, L. (2013) · Nature Neuroscience · doi:10.1038/nn.3356 · Cited by 487 · see citing works
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works
Self-citationHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
Simões-Pires, C., Zwick, V., Nurisso, A., Schenker, E., Carrupt, P.-A., & Cuendet, M. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-7 · Cited by 341 · see citing works
HDAC6 is a target for protection and regeneration following injury in the nervous system
Rivieccio, M. A., Brochier, C., Willis, D. E., Walker, B. A., D'Annibale, M. A., McLaughlin, K., Siddiq, A., Kozikowski, A. P., Jaffrey, S. R., Twiss, J. L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907935106 · Cited by 322 · see citing works
Shukla, S., & Tekwani, B. L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00537 · Cited by 314 · see citing works
Nuclear genomic instability and aging
Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J., & Robbins, P. D. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012239 · Cited by 275 · see citing works
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Dobbin, M. M., Madabhushi, R., Pan, L., Chen, Y., Kim, D., Gao, J., Ahanonu, B., Pao, P.-C., Qiu, Y., Zhao, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3460 · Cited by 250 · see citing works
Self-citationPao, P.-C., Patnaik, D., Watson, L. A., Gao, F., Pan, L., Wang, J., Adaikkan, C., Penney, J., Cam, H. P., Huang, W.-C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16361-y · Cited by 216 · see citing works
Wang, J., Zibetti, C., Shang, P., Sripathi, S. R., Zhang, P., Cano, M., Hoang, T., Xia, S., Ji, H., Merbs, S. L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03856-y · Cited by 185 · see citing works
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Basheer, N., Smolek, T., Hassan, I., Liu, F., Iqbal, K., Zilka, N., & Novak, P. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02113-z · Cited by 159 · see citing works
Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.038 · Cited by 130 · see citing works
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Gavin, D. P., & Sharma, R. P. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.010 · Cited by 121 · see citing works
Contributions of DNA Damage to Alzheimer’s Disease
Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117 · see citing works
Zhao, Z., Fan, L., Fortress, A. M., Boulware, M. I., & Frick, K. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5819-11.2012 · Cited by 115 · see citing works
Epigenetic memory: The Lamarckian brain
Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107 · see citing works
Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers
Wagner, F. F., Zhang, Y.-L., Fass, D. M., Joseph, N., Gale, J. P., Weïwer, M., McCarren, P., Fisher, S. L., Kaya, T., Zhao, W.-N., et al. (2015) · Chemical Science · doi:10.1039/c4sc02130d · Cited by 104 · see citing works
Self-citationCdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex
Zhang, J., Li, H., Yabut, O., Fitzpatrick, H., D'Arcangelo, G., & Herrup, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5628-09.2010 · Cited by 96 · see citing works
Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo4662 · Cited by 84 · see citing works
Self-citationLi, Y., Sang, S., Ren, W., Pei, Y., Bian, Y., Chen, Y., & Sun, H. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113874 · Cited by 77 · see citing works
Brureau, A., Blanchard-Bregeon, V., Pech, C., Hamon, S., Chaillou, P., Guillemot, J.-C., Barneoud, P., Bertrand, P., Pradier, L., Rooney, T., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.007 · Cited by 62 · see citing works
Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry
Archer, T., & Blum, K. (2012) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000115 · Cited by 54 · see citing works
Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes
Moruno-Manchon, J. F., Uzor, N.-E., Ambati, C. R., Shetty, V., Putluri, N., Jagannath, C., McCullough, L. D., & Tsvetkov, A. S. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0599-5 · Cited by 36 · see citing works
Histone Deacetylases 1 and 2 in Memory Function
Pao, P.-C., & Tsai, L.-H. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00775 · Cited by 34 · see citing works
Self-citationHirata, Y., Sasaki, T., Kanki, H., Choong, C.-J., Nishiyama, K., Kubo, G., Hotei, A., Taniguchi, M., Mochizuki, H., & Uesato, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19664-9 · Cited by 20 · see citing works
Association of histone modification with the development of schizophrenia
Chen, Y.-Z., Zhu, X.-M., Lv, P., Hou, X.-K., Pan, Y., Li, A., Du, Z., Xuan, J.-F., Guo, X., Xing, J.-X., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116747 · Cited by 18 · see citing works
- Authors
- Kim, D., Frank, C. L., Dobbin, M. M., Tsunemoto, R. K., Tu, W., Peng, P. L., Guan, J.-S., Lee, B.-H., Moy, L. Y., Giusti, P., Broodie, N., Mazitschek, R., Delalle, I., Haggarty, S. J., Neve, R. L., Lu, Y., & Tsai, L.-H.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Central Florida (US)
- Broad Institute (US)
- Harvard University (US)
- Corresponding author
- Tsai, Li-Huei
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 60
- Issue
- 5
- Pages
- 803-817
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2912147
- OpenAlex
- W2068676111
- Cited by
- 286
- References
- 70
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 17 · 2020: 15 · 2019: 13 · 2018: 17 · 2017: 20 · 2016: 18 · 2015: 16 · 2014: 21 · 2013: 27 · 2012: 22
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1725 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Journal of International Crisis and Risk Communication Research (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (P01AG27916, P01AG027916)
- National Institute of Neurological Disorders and Stroke (R01NS051383)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- HDAC1, neurotoxicity, DNA double-strand breaks, DNA damage, neuronal cell death, neurodegeneration, ischemia, histone deacetylase
- MeSH terms
- Chromobox Protein Homolog 5, Animals, Animals, Newborn, Cell Cycle, Cells, Cultured, Cerebral Cortex, Conditioning, Psychological, DNA Damage, Fear, Histone Deacetylases, Humans, Ischemia, Mice, Inbred C57BL, Mice, Transgenic, Nerve Degeneration, Nerve Tissue, Neurons, Transfection, Gene Expression, Prosencephalon, Proliferating Cell Nuclear Antigen, Ki-67 Antigen, Comet Assay, Gene Expression Profiling, Chromatin Immunoprecipitation, Green Fluorescent Proteins, Cyclin-Dependent Kinase 5, Mice, Rats, DNA Breaks, Double-Stranded, Histone Deacetylase 1
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