Schief, William R.

Macromolecular modeling and design in Rosetta: recent methods and frameworks

Leman, J. K., Weitzner, B. D., Lewis, S. M., Adolf-Bryfogle, J., Alam, N., Alford, R. F., Aprahamian, M., Baker, D., Barlow, K. A., Barth, P., et al. (2020) · Nature Methods

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 888

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J.-P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K., et al. (2011) · Nature

HIV Research and TreatmentCarbohydrate Chemistry and Synthesis

Cited by 830

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

Jardine, J., Julien, J.-P., Menis, S., Ota, T., Kalyuzhniy, O., McGuire, A., Sok, D., Huang, P.-S., MacPherson, S., Jones, M., et al. (2013) · Science

HIV Research and TreatmentSARS-CoV-2 and COVID-19 Research

Cited by 770

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P.-S., Wang, S.-K., Stanfield, R. L., Julien, J.-P., Ramos, A., Crispin, M., et al. (2011) · Science

HIV Research and TreatmentMonoclonal and Polyclonal Antibodies Research

Cited by 694

Proof of principle for epitope-focused vaccine design

Correia, B. E., Bates, J. T., Loomis, R. J., Baneyx, G., Carrico, C., Jardine, J. G., Rupert, P., Correnti, C., Kalyuzhniy, O., Vittal, V., et al. (2014) · Nature

vaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Cited by 555

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., et al. (2019) · Cell

HIV Research and TreatmentSARS-CoV-2 and COVID-19 Research

Cited by 433

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

McGuire, A. T., Hoot, S., Dreyer, A. M., Lippy, A., Stuart, A., Cohen, K. W., Jardine, J., Menis, S., Scheid, J. F., West, A. P., et al. (2013) · Journal of Experimental Medicine

HIV Research and TreatmentMonoclonal and Polyclonal Antibodies Research

Cited by 309

Elicitation of structure-specific antibodies by epitope scaffolds

Ofek, G., Guenaga, F. J., Schief, W. R., Skinner, J., Baker, D., Wyatt, R., & Kwong, P. D. (2010) · Proceedings of the National Academy of Sciences

HIV Research and Treatmentvaccines and immunoinformatics approaches

Cited by 278

RosettaAntibodyDesign (RAbD): a general framework for computational antibody design

Adolf-Bryfogle, J., Kalyuzhniy, O., Kubitz, M., Weitzner, B. D., Hu, X., Adachi, Y., Schief, W. R., & Dunbrack, R. L. (2018) · PLoS Computational Biology

Protein Structure and DynamicsMonoclonal and Polyclonal Antibodies Research

Cited by 227

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Azoitei, M. L., Correia, B. E., Ban, Y.-E. A., Carrico, C., Kalyuzhniy, O., Chen, L., Schroeter, A., Huang, P.-S., McLellan, J. S., Kwong, P. D., et al. (2011) · Science

Protein Structure and DynamicsBiochemical and Structural Characterization

Cited by 224

Conformational changes during kinesin motility

Schief, W. R., & Howard, J. (2001) · Current Opinion in Cell Biology

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 131

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

Procko, E., Berguig, G. Y., Shen, B. W., Song, Y., Frayo, S., Convertine, A. J., Margineantu, D., Booth, G., Correia, B. E., Cheng, Y., et al. (2014) · Cell

Cell death mechanisms and regulationChemical Synthesis and Analysis

Cited by 127

Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism

Schief, W. R., Clark, R. H., Crevenna, A. H., & Howard, J. (2004) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsATP Synthase and ATPases Research

Cited by 119

Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

Melo, M., Porter, E., Zhang, Y., Silva, M., Li, N., Dobosh, B., Liguori, A., Skog, P., Landais, E., Menis, S., et al. (2019) · Molecular Therapy

RNA Interference and Gene DeliveryHIV Research and Treatment

Cited by 88

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization

Havenar-Daughton, C., Carnathan, D. G., Boopathy, A. V., Upadhyay, A. A., Murrell, B., Reiss, S. M., Enemuo, C. A., Gebru, E. H., Choe, Y., Dhadvai, P., et al. (2019) · Cell Reports

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 58