Roskams, Tania

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 747

Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

Mossanen, J. C., Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., et al. (2016) · Hepatology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 325

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 261

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

Verbeke, L., Farre, R., Trebicka, J., Komuta, M., Roskams, T., Klein, S., Elst, I. V., Windmolders, P., Vanuytsel, T., Nevens, F., et al. (2014) · Hepatology

Liver Disease and TransplantationLiver physiology and pathology

Cited by 258

The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats

Verbeke, L., Farre, R., Verbinnen, B., Covens, K., Vanuytsel, T., Verhaegen, J., Komuta, M., Roskams, T., Chatterjee, S., Annaert, P., et al. (2015) · The American Journal of Pathology

Drug Transport and Resistance MechanismsLiver Disease and Transplantation

Cited by 225

Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation

ANNE, W., WILLEMS, R., ROSKAMS, T., SERGEANT, P., HERIJGERS, P., HOLEMANS, P., ECTOR, H., & HEIDBUCHEL, H. (2005) · Cardiovascular Research

Atrial Fibrillation Management and OutcomesCardiac Fibrosis and Remodeling

Cited by 210

Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling

Spee, B., Carpino, G., Schotanus, B. A., Katoonizadeh, A., Borght, S. V., Gaudio, E., & Roskams, T. (2010) · Gut

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 208

The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury

Klein, C., Wüstefeld, T., Assmus, U., Roskams, T., Rose-John, S., Müller, M., Manns, M. P., Ernst, M., & Trautwein, C. (2005) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 200

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

Hammerich, L., Bangen, J. M., Govaere, O., Zimmermann, H. W., Gassler, N., Huss, S., Liedtke, C., Prinz, I., Lira, S. A., Luedde, T., et al. (2014) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 190

Histidine‐rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease

Bartneck, M., Fech, V., Ehling, J., Govaere, O., Warzecha, K. T., Hittatiya, K., Vucur, M., Gautheron, J., Luedde, T., Trautwein, C., et al. (2016) · Hepatology

Liver physiology and pathologyImmune cells in cancer

Cited by 101

Self-terminating AF depends on electrical remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model

Anné, W., Willems, R., Holemans, P., Beckers, F., Roskams, T., Lenaerts, I., Ector, H., & Heidbüchel, H. (2007) · Journal of Molecular and Cellular Cardiology

Atrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmias

Cited by 91

Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis

Verboven, E., Moya, I. M., Sansores-Garcia, L., Xie, J., Hillen, H., Kowalczyk, W., Vella, G., Verhulst, S., Castaldo, S. A., Algueró-Nadal, A., et al. (2021) · Gastroenterology

Liver physiology and pathologyHippo pathway signaling and YAP/TAZ

Cited by 87

Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling

Rosenberg, N., Van Haele, M., Lanton, T., Brashi, N., Bromberg, Z., Adler, H., Giladi, H., Peled, A., Goldenberg, D. S., Axelrod, J. H., et al. (2022) · Journal of Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 72

High‐throughput sequencing identifies aetiology‐dependent differences in ductular reaction in human chronic liver disease

Govaere, O., Cockell, S., Van Haele, M., Wouters, J., Van Delm, W., Van den Eynde, K., Bianchi, A., van Eijsden, R., Van Steenbergen, W., Monbaliu, D., et al. (2019) · The Journal of Pathology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 61

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Roehlen, N., Saviano, A., El Saghire, H., Crouchet, E., Nehme, Z., Del Zompo, F., Jühling, F., Oudot, M. A., Durand, S. C., Duong, F. H. T., et al. (2022) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 54

Contribution of Interleukin‐6/gp130 Signaling in Hepatocytes to the Inflammatory Response in Mice Infected with Streptococcus pyogenes

Klein, C., Medina, E., Sander, L., Dierssen, U., Roskams, T., Mueller, W., Trautwein, C., & Goldmann, O. (2007) · The Journal of Infectious Diseases

Sepsis Diagnosis and TreatmentCytokine Signaling Pathways and Interactions

Cited by 11