Fred, Senem Merve

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Casarotto, P. C., Girych, M., Fred, S. M., Kovaleva, V., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Sahu, M. P., Kaurinkoski, K., et al. (2021) · Cell

Treatment of Major DepressionNerve injury and regeneration

Cited by 663

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Moliner, R., Girych, M., Brunello, C. A., Kovaleva, V., Biojone, C., Enkavi, G., Antenucci, L., Kot, E. F., Goncharuk, S. A., Kaurinkoski, K., et al. (2023) · Nature Neuroscience

Psychedelics and Drug StudiesTreatment of Major Depression

Cited by 478

Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons

Lesnikova, A., Casarotto, P. C., Fred, S. M., Voipio, M., Winkel, F., Steinzeig, A., Antila, H., Umemori, J., Biojone, C., & Castrén, E. (2021) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 56

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

Fred, S. M., Laukkanen, L., Brunello, C. A., Vesa, L., Göös, H., Cardon, I., Moliner, R., Maritzen, T., Varjosalo, M., Casarotto, P. C., et al. (2019) · Journal of Biological Chemistry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 52

Perineuronal Net Receptor PTPσ Regulates Retention of Memories

Lesnikova, A., Casarotto, P., Moliner, R., Fred, S. M., Biojone, C., & Castrén, E. (2021) · Frontiers in Synaptic Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 21