Papagiannakopoulos, Thales

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R. (2017) · Nature

Ferroptosis and cancer prognosisCancer, Hypoxia, and Metabolism

Cited by 787

CRISPR-mediated direct mutation of cancer genes in the mouse liver

Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N. S., Cai, W., Yang, G., Bronson, R., Crowley, D. G., et al. (2014) · Nature

CRISPR and Genetic EngineeringCancer Genomics and Diagnostics

Cited by 776

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

Davidson, S. M., Papagiannakopoulos, T., Olenchock, B. A., Heyman, J. E., Keibler, M. A., Luengo, A., Bauer, M. R., Jha, A. K., O’Brien, J. P., Pierce, K. A., et al. (2016) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 737

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

Papagiannakopoulos, T., Shapiro, A., & Kosik, K. S. (2008) · Cancer Research

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 705

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

Romero, R., Sayin, V. I., Davidson, S. M., Bauer, M. R., Singh, S. X., LeBoeuf, S. E., Karakousi, T. R., Ellis, D. C., Bhutkar, A., Sánchez-Rivera, F. J., et al. (2017) · Nature Medicine

Genomics, phytochemicals, and oxidative stressLung Cancer Treatments and Mutations

Cited by 652

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras -driven cancers

Mayers, J. R., Torrence, M. E., Danai, L. V., Papagiannakopoulos, T., Davidson, S. M., Bauer, M. R., Lau, A. N., Ji, B. W., Dixit, P. D., Hosios, A. M., et al. (2016) · Science

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 582

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

Lignitto, L., LeBoeuf, S. E., Homer, H., Jiang, S., Askenazi, M., Karakousi, T. R., Pass, H. I., Bhutkar, A. J., Tsirigos, A., Ueberheide, B., et al. (2019) · Cell

Genomics, phytochemicals, and oxidative stressMechanisms of cancer metastasis

Cited by 573

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

Papagiannakopoulos, T., Bauer, M. R., Davidson, S. M., Heimann, M., Subbaraj, L., Bhutkar, A., Bartlebaugh, J., Vander Heiden, M. G., & Jacks, T. (2016) · Cell Metabolism

Circadian rhythm and melatoninSleep and Work-Related Fatigue

Cited by 557

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

Garcia-Bermudez, J., Baudrier, L., La, K., Zhu, X. G., Fidelin, J., Sviderskiy, V. O., Papagiannakopoulos, T., Molina, H., Snuderl, M., Lewis, C. A., et al. (2018) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 442

Lower Airway Dysbiosis Affects Lung Cancer Progression

Tsay, J.-C. J., Wu, B. G., Sulaiman, I., Gershner, K., Schluger, R., Li, Y., Yie, T.-A., Meyn, P., Olsen, E., Perez, L., et al. (2021) · Cancer Discovery

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 322

Lung adenocarcinoma distally rewires hepatic circadian homeostasis

Masri, S., Papagiannakopoulos, T., Kinouchi, K., Liu, Y., Cervantes, M., Baldi, P., Jacks, T., & Sassone-Corsi, P. (2016) · Cell

Circadian rhythm and melatoninMetabolism, Diabetes, and Cancer

Cited by 234

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Sayin, V. I., LeBoeuf, S. E., Singh, S. X., Davidson, S. M., Biancur, D., Guzelhan, B. S., Alvarez, S. W., Wu, W. L., Karakousi, T. R., Zavitsanou, A. M., et al. (2017) · eLife

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 231

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

LeBoeuf, S. E., Wu, W. L., Karakousi, T. R., Karadal, B., Jackson, S. R., Davidson, S. M., Wong, K.-K., Koralov, S. B., Sayin, V. I., & Papagiannakopoulos, T. (2020) · Cell Metabolism

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 150

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

Deng, J., Thennavan, A., Dolgalev, I., Chen, T., Li, J., Marzio, A., Poirier, J. T., Peng, D. H., Bulatovic, M., Mukhopadhyay, S., et al. (2021) · Nature Cancer

Cancer Immunotherapy and BiomarkersAutophagy in Disease and Therapy

Cited by 140

Metabolic features of cancer cells in NRF2 addiction status

Okazaki, K., Papagiannakopoulos, T., & Motohashi, H. (2020) · Biophysical Reviews

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 57