Granrath, Ross E.

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

Araya, P., Waugh, K. A., Sullivan, K. D., Núñez, N. G., Roselli, E., Smith, K. P., Granrath, R. E., Rachubinski, A. L., Enriquez Estrada, B., Butcher, E. T., et al. (2019) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyDown syndrome and intellectual disability research

Cited by 179

Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

Waugh, K. A., Araya, P., Pandey, A., Jordan, K. R., Smith, K. P., Granrath, R. E., Khanal, S., Butcher, E. T., Estrada, B. E., Rachubinski, A. L., et al. (2019) · Cell Reports

Down syndrome and intellectual disability researchinterferon and immune responses

Cited by 150

Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model

Waugh, K. A., Minter, R., Baxter, J., Chi, C., Galbraith, M. D., Tuttle, K. D., Eduthan, N. P., Kinning, K. T., Andrysik, Z., Araya, P., et al. (2023) · Nature Genetics

Down syndrome and intellectual disability researchinterferon and immune responses

Cited by 117

Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition

Galbraith, M. D., Rachubinski, A. L., Smith, K. P., Araya, P., Waugh, K. A., Enriquez-Estrada, B., Worek, K., Granrath, R. E., Kinning, K. T., Paul Eduthan, N., et al. (2023) · Science Advances

Down syndrome and intellectual disability researchinterferon and immune responses

Cited by 88

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

Tuttle, K. D., Waugh, K. A., Araya, P., Minter, R., Orlicky, D. J., Ludwig, M., Andrysik, Z., Burchill, M. A., Tamburini, B. A. J., Sempeck, C., et al. (2020) · Cell Reports

interferon and immune responsesDown syndrome and intellectual disability research

Cited by 72

IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome

Araya, P., Kinning, K. T., Coughlan, C., Smith, K. P., Granrath, R. E., Enriquez-Estrada, B. A., Worek, K., Sullivan, K. D., Rachubinski, A. L., Wolter-Warmerdam, K., et al. (2022) · Cell Reports

Down syndrome and intellectual disability researchGrowth Hormone and Insulin-like Growth Factors

Cited by 50

JAK inhibition decreases the autoimmune burden in Down syndrome

Rachubinski, A. L., Wallace, E., Gurnee, E., Enriquez-Estrada, B. A., Worek, K. R., Smith, K. P., Araya, P., Waugh, K. A., Granrath, R. E., Britton, E., et al. (2024) · eLife

Down syndrome and intellectual disability researchImmunodeficiency and Autoimmune Disorders

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