Harris, Isaac S.

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 4,744

Modulation of oxidative stress as an anticancer strategy

Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery

Redox biology and oxidative stressCancer and biochemical research

Cited by 3,579

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Harris, I. S., Treloar, A. E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K. C., Yung, K. Y., Brenner, D., Knobbe-Thomsen, C. B., Cox, M. A., et al. (2015) · Cancer Cell

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 993

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Sasaki, M., Knobbe, C. B., Munger, J. C., Lind, E. F., Brenner, D., Brüstle, A., Harris, I. S., Holmes, R., Wakeham, A., Haight, J., et al. (2012) · Nature

Acute Myeloid Leukemia ResearchGlioma Diagnosis and Treatment

Cited by 513

Glutathione primes t cell metabolism for inflammation

Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Brüstle, A., Itsumi, M., et al. (2017) · Immunity

Redox biology and oxidative stressT-cell and B-cell Immunology

Cited by 511

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

Sasaki, M., Knobbe, C. B., Itsumi, M., Elia, A. J., Harris, I. S., Chio, I. I. C., Cairns, R. A., McCracken, S., Wakeham, A., Haight, J., et al. (2012) · Genes & Development

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 296

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

Gorrini, C., Baniasadi, P. S., Harris, I. S., Silvester, J., Inoue, S., Snow, B., Joshi, P. A., Wakeham, A., Molyneux, S. D., Martin, B., et al. (2013) · Journal of Experimental Medicine

Genomics, phytochemicals, and oxidative stressBRCA gene mutations in cancer

Cited by 289

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

Coloff, J. L., Murphy, J. P., Braun, C. R., Harris, I. S., Shelton, L. M., Kami, K., Gygi, S. P., Selfors, L. M., & Brugge, J. S. (2016) · Cell Metabolism

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

Cited by 288

FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2

Bakker, W. J., Harris, I. S., & Mak, T. W. (2007) · Molecular Cell

FOXO transcription factor regulationCancer, Hypoxia, and Metabolism

Cited by 277

Global proteomic assessment of the classical protein-tyrosine phosphatome and “Redoxome”

Karisch, R., Fernandez, M., Taylor, P., Virtanen, C., St-Germain, J. R., Jin, L. L., Harris, I. S., Mori, J., Mak, T. W., Senis, Y. A., et al. (2011) · Cell

Protein Tyrosine PhosphatasesRedox biology and oxidative stress

Cited by 179

Targeting oncoproteins with a positive selection assay for protein degraders

Koduri, V., Duplaquet, L., Lampson, B. L., Wang, A. C., Sabet, A. H., Ishoey, M., Paulk, J., Teng, M., Harris, I. S., Endress, J. E., et al. (2021) · Science Advances

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 44