Modulation of oxidative stress as an anticancer strategy
Abstract
The regulation of oxidative stress is an important factor in both tumour development and responses to anticancer therapies. Many signalling pathways that are linked to tumorigenesis can also regulate the metabolism of reactive oxygen species (ROS) through direct or indirect mechanisms. High ROS levels are generally detrimental to cells, and the redox status of cancer cells usually differs from that of normal cells. Because of metabolic and signalling aberrations, cancer cells exhibit elevated ROS levels. The observation that this is balanced by an increased antioxidant capacity suggests that high ROS levels may constitute a barrier to tumorigenesis. However, ROS can also promote tumour formation by inducing DNA mutations and pro-oncogenic signalling pathways. These contradictory effects have important implications for potential anticancer strategies that aim to modulate levels of ROS. In this Review, we address the controversial role of ROS in tumour development and in responses to anticancer therapies, and elaborate on the idea that targeting the antioxidant capacity of tumour cells can have a positive therapeutic impact.
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Inhibition of the thioredoxin system has been proposed as a novel anticancer approach.
“Inhibition of the thioredoxin system has been proposed as a novel anticancer approach34,40,41.”
From Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246 (2018) · cites this paper as [41]
Cancer cells are under increased oxidative stress caused by oncogenic transformation, leading to metabolic alterations that result in ROS production.
“Recent studies suggest that cancer cells are under increased oxidative stress caused by oncogenic transformation, leading to metabolic alterations that result in ROS production56.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [56]
High levels of ROS cause damage to proteins, nucleic acids, lipids, membranes, and organelles, leading to cell death.
“In contrast, high levels of ROS cause damage to proteins, nucleic acids, lipids, membranes, and organelles, leading to cell death.”
From Reactive Oxygen Species in Cancer: Current Findings and Future Directions (2021) · cites this paper as [8]
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- Authors
- Gorrini, C., Harris, I. S., & Mak, T. W.
- Affiliations
- University Health Network (CA)
- Corresponding author
- Mak, Tak W.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2013-11-29
- Volume
- 12
- Issue
- 12
- Pages
- 931-947
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1969524738
- Cited by
- 3,579
- References
- 225
- Citations by year
- 2026: 214 · 2025: 287 · 2024: 295 · 2023: 319 · 2022: 366 · 2021: 372 · 2020: 342 · 2019: 328 · 2018: 300 · 2017: 273 · 2016: 227 · 2015: 166 · 2014: 83 · 2013: 1
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, oxidative stress, antioxidant pathways, cancer cells, carcinogenesis, cancer therapy, redox signaling, DNA mutations, cancer metabolism
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Neoplasms, Reactive Oxygen Species, Oxidative Stress
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