Spitale, Robert C.

Landscape and variation of RNA secondary structure across the human transcriptome

Wan, Y., Qu, K., Zhang, Q. C., Flynn, R. A., Manor, O., Ouyang, Z., Zhang, J., Spitale, R. C., Snyder, M. P., Segal, E., et al. (2014) · Nature

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 555

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

Hasselmann, J., Coburn, M. A., England, W., Figueroa Velez, D. X., Kiani Shabestari, S., Tu, C. H., McQuade, A., Kolahdouzan, M., Echeverria, K., Claes, C., et al. (2019) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 380

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

Arda, H. E., Li, L., Tsai, J., Torre, E. A., Rosli, Y., Peiris, H., Spitale, R. C., Dai, C., Gu, X., Qu, K., et al. (2016) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 222

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

Claes, C., Danhash, E. P., Hasselmann, J., Chadarevian, J. P., Shabestari, S. K., England, W. E., Lim, T. E., Hidalgo, J. L. S., Spitale, R. C., Davtyan, H., et al. (2021) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 197

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

Chadarevian, J. P., Hasselmann, J., Lahian, A., Capocchi, J. K., Escobar, A., Lim, T. E., Le, L., Tu, C., Nguyen, J., Kiani Shabestari, S., et al. (2024) · Neuron

Neuroinflammation and Neurodegeneration MechanismsPluripotent Stem Cells Research

Cited by 83

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

Li, X., Zhao, Q., Wei, W., Lin, Q., Magnan, C., Emami, M. R., Wearick-Silva, L. E., Viola, T. W., Marshall, P. R., Yin, J., et al. (2019) · Nature Neuroscience

Epigenetics and DNA MethylationMemory and Neural Mechanisms

Cited by 71

The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model

Claes, C., England, W. E., Danhash, E. P., Kiani Shabestari, S., Jairaman, A., Chadarevian, J. P., Hasselmann, J., Tsai, A. P., Coburn, M. A., Sanchez, J., et al. (2022) · Alzheimer's & Dementia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 52

Structural disruption of exonic stem–loops immediately upstream of the intron regulates mammalian splicing

Saha, K., England, W., Fernandez, M. M., Biswas, T., Spitale, R. C., & Ghosh, G. (2020) · Nucleic Acids Research

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 25

Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing

Saha, K., England, W., Fernandez, M. M., Biswas, T., Spitale, R. C., & Ghosh, G. (2018) · Nucleic Acids Research

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 25

Aberrant splicing in Huntington’s disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification

Nguyen, T. B., Miramontes, R., Chillon-Marinas, C., Maimon, R., Vazquez-Sanchez, S., Lau, A. L., McClure, N. R., England, W. E., Singha, M., Stocksdale, J. T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Genetic Neurodegenerative DiseasesRNA Research and Splicing

Cited by 15