Kang, Seong Su

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

Zhang, Z., Song, M., Liu, X., Kang, S. S., Kwon, I.-S., Duong, D. M., Seyfried, N. T., Hu, W. T., Liu, Z., Wang, J.-Z., et al. (2014) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 494

FSH blockade improves cognition in mice with Alzheimer’s disease

Xiong, J., Kang, S. S., Wang, Z., Liu, X., Kuo, T.-C., Korkmaz, F., Padilla, A., Miyashita, S., Chan, P., Zhang, Z., et al. (2022) · Nature

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 329

Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

Chen, C., Ahn, E. H., Kang, S. S., Liu, X., Alam, A., & Ye, K. (2020) · Science Advances

Alzheimer's disease research and treatmentsGut microbiota and health

Cited by 205

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

Zhang, Z., Obianyo, O., Dall, E., Du, Y., Fu, H., Liu, X., Kang, S. S., Song, M., Yu, S.-P., Cabrele, C., et al. (2017) · Nature Communications

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 146

High-fat diet-induced diabetes couples to Alzheimer’s disease through inflammation-activated C/EBPβ/AEP pathway

Liu, P., Wang, Z.-H., Kang, S. S., Liu, X., Xia, Y., Chan, C.-B., & Ye, K. (2022) · Molecular Psychiatry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 77

C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

Wang, H., Chen, G., Ahn, E. H., Xia, Y., Kang, S. S., Liu, X., Liu, C., Han, M.-H., Chen, S., & Ye, K. (2023) · npj Parkinson's Disease

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 71

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies

Chen, G., Kang, S. S., Wang, Z., Ahn, E. H., Xia, Y., Liu, X., Sandoval, I. M., Manfredsson, F. P., Zhang, Z., & Ye, K. (2021) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 44

Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer’s disease pathogenesis

Wu, Z., Chen, C., Kang, S. S., Liu, X., Gu, X., Yu, S. P., Keene, C. D., Cheng, L., & Ye, K. (2021) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 34

UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease

Chen, G., Ahn, E. H., Kang, S. S., Xia, Y., Liu, X., Zhang, Z., & Ye, K. (2022) · Advanced Science

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 28

ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer’s disease

Chen, G., Wang, M., Zhang, Z., Hong, D. K., Ahn, E. H., Liu, X., Kang, S. S., & Ye, K. (2025) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 21