Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works

Gut microbiome alterations in Alzheimer’s disease

Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047 · see citing works

Gut microbiota are related to Parkinson's disease and clinical phenotype

Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968 · see citing works

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Li, W., Björklund, T., Wang, Z.-Y., Roybon, L., Melki, R., & Li, J.-Y. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1343-6 · Cited by 925 · see citing works

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921 · see citing works

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885 · see citing works

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Jang, S., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913572107 · Cited by 689 · see citing works

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., et al. (2016) · Scientific Reports · doi:10.1038/srep30028 · Cited by 655 · see citing works

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Kim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614 · see citing works

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

Zhang, Z., Song, M., Liu, X., Kang, S. S., Kwon, I.-S., Duong, D. M., Seyfried, N. T., Hu, W. T., Liu, Z., Wang, J.-Z., et al. (2014) · Nature Medicine · doi:10.1038/nm.3700 · Cited by 494 · see citing works

The Gut Microbiota and Autism Spectrum Disorders

Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462 · see citing works

Alzheimer’s disease microbiome is associated with dysregulation of the anti-inflammatory p-glycoprotein pathway

Haran, J. P., Bhattarai, S. K., Foley, S. E., Dutta, P., Ward, D. V., Bucci, V., & McCormick, B. A. (2019) · mBio · doi:10.1128/mbio.00632-19 · Cited by 412 · see citing works

Alzheimer’s disease and gut microbiota

Hu, X., Wang, T., & Jin, F. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5083-9 · Cited by 371 · see citing works

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

Zhang, Z., Song, M., Liu, X., Kang, S. S., Duong, D. M., Seyfried, N. T., Cao, X., Cheng, L., Sun, Y. E., Yu, S. P., et al. (2015) · Nature Communications · doi:10.1038/ncomms9762 · Cited by 289 · see citing works

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

Dodiya, H. B., Kuntz, T., Shaik, S. M., Baufeld, C., Leibowitz, J., Zhang, X., Gottel, N., Zhang, X., Butovsky, O., Gilbert, J. A., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182386 · Cited by 288 · see citing works

Alzheimer’s Disease Histological and Behavioral Manifestations in Transgenic Mice Correlate with Specific Gut Microbiome State

Shen, L., Liu, L., & Ji, H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160884 · Cited by 280 · see citing works

Glycans as legislators of host-microbial interactions: spanning the spectrum from symbiosis to pathogenicity

Hooper, L. V., & Gordon, J. I. (2001) · Glycobiology · doi:10.1093/glycob/11.2.1r · Cited by 263 · see citing works

The C/EBP Family of Transcription Factors

Wedel, A., & Lömsziegler-Heitbrock, H. W. (1995) · Immunobiology · doi:10.1016/s0171-2985(11)80541-3 · Cited by 245 · see citing works

The microenvironment of injured murine gut elicits a local pro-restitutive microbiota

Alam, A. M., Leoni, G., Quirós, M., Wu, H., Desai, C., Nishio, H., Jones, R. M., Nusrat, A., & Neish, A. S. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2015.21 · Cited by 243 · see citing works

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

Zhang, Z., Liu, X., Schroeder, J. P., Chan, C.-B., Song, M., Yu, S. P., Weinshenker, D., & Ye, K. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.243 · Cited by 242 · see citing works

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

Wang, Z.-H., Xiang, J., Liu, X., Yu, S. P., Manfredsson, F. P., Sandoval, I. M., Wu, S., Wang, J.-Z., & Ye, K. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.054 · Cited by 238 · see citing works

The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection

Stecher, B. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mbp-0008-2014 · Cited by 235 · see citing works

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

Chen, C., Wang, Z., Zhang, Z., Liu, X., Kang, S. S., Zhang, Y., & Ye, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718683115 · Cited by 169 · see citing works

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

Wang, Z.-H., Gong, K. Q., Liu, X., Zhang, Z., Sun, X., Wei, Z. Z., Yu, S. P., Manfredsson, F. P., Sandoval, I. M., Johnson, P. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04120-z · Cited by 140 · see citing works

Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis.

Perán, L., Camuesco, D., Comalada, M., Nieto, A., Concha, Á., Díaz-Ropero, M. P., Olivares, M. M., Xaus, J., Zarzuelo, A., & Gálvez, J. (2005) · Europe PMC (PubMed Central) · doi:10.3748/wjg.v11.i33.5185 · Cited by 136 · see citing works

Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve with insulin resistance?

Esteve, E., Ricart, W., & Fernández-Real, J.-M. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328348c06d · Cited by 133 · see citing works

Initiation of Parkinson’s disease from gut to brain by δ-secretase

Ahn, E. H., Kang, S. S., Liu, X., Chen, G., Zhang, Z., Chandrasekharan, B. P., Alam, A. M., Neish, A. S., Cao, X., & Ye, K. (2019) · Cell Research · doi:10.1038/s41422-019-0241-9 · Cited by 103 · see citing works

Netrin-1 Signaling Dampens Inflammatory Peritonitis

Mirakaj, V., Gatidou, D., Pötzsch, C., König, K., & Rosenberger, P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002671 · Cited by 79 · see citing works

The intricate association between gut microbiota and development of Type 1, Type 2 and Type 3 diabetes

Bekkering, P., Jafri, I., van Overveld, F. J., & Rijkers, G. T. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.848793 · Cited by 77 · see citing works

Selective affective biasing in recognition memory in the irritable bowel syndrome.

Gomborone, J., Dewsnap, P., Libby, G., & Farthing, M. J. G. (1993) · Gut · doi:10.1136/gut.34.9.1230 · Cited by 67 · see citing works

Brain‐derived neurotrophic factor accelerates gut motility in slow‐transit constipation

Chen, F., Yu, Y., Wang, P., Dong, Y., Wang, T., Zuo, X., & Li, Y. (2014) · Acta Physiologica · doi:10.1111/apha.12374 · Cited by 54 · see citing works

Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia

Basurto‐Islas, G., Gu, J., Tung, Y. C., Liu, F., & Iqbal, K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170715 · Cited by 41 · see citing works

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest

Foiani, M. S., Cicognola, C., Ermann, N., Woollacott, I., Heller, C., Heslegrave, A., Keshavan, A., Paterson, R. W., Ye, K., Kornhuber, J., et al. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319266 · Cited by 35 · see citing works

Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease

Wang, H., Liu, X., Chen, S., & Ye, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815915115 · Cited by 32 · see citing works

Role of IL-1β and corticosteroids in the regulation of the C/EBP-α, β and δ genes in vivo

Magalini, A. R., Savoldi, G., Ferrari, F., Garnier, M. J., Ghezzi, P., Albertini, A., & Lorenzo, D. D. (1995) · Cytokine · doi:10.1006/cyto.1995.0090 · Cited by 28 · see citing works

Proinflammatory Role of Monocyte-Derived CX3CR1 int Macrophages in Helicobacter hepaticus-Induced Colitis

Bain, C. C., Oliphant, C. J., Thomson, C. A., Kullberg, M. C., & Mowat, A. M. (2017) · Infection and Immunity · doi:10.1128/iai.00579-17 · Cited by 27 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

Role and Mechanism of Gut Microbiota in Human Disease

Chen, Y., Zhou, J., & Wang, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.625913 · Cited by 643 · see citing works

Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Chen, C., Liao, J., Xia, Y., Liu, X., Jones, R., Haran, J., McCormick, B., Sampson, T. R., Alam, A., & Ye, K. (2022) · Gut · doi:10.1136/gutjnl-2021-326269 · Cited by 491 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

Shabbir, U., Rubab, M., Daliri, E. B., Chelliah, R., Javed, A., & Oh, D. (2021) · Nutrients · doi:10.3390/nu13010206 · Cited by 338 · see citing works

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278 · see citing works

A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia

Xiao, S., Chan, P., Wang, T., Hong, Z., Wang, S., Kuang, W., He, J., Pan, X., Zhou, Y., Ji, Y., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00795-7 · Cited by 224 · see citing works

The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects

Li, C.-L., Peng, K., Xiao, S., Long, Y., & Yu, Q. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01666-w · Cited by 218 · see citing works

Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis

Chen, C., Rao, S., Yue, T., Tan, Y., Yin, H., Chen, L.-J., Luo, M., Wang, Z., Wang, Y., Hong, C., et al. (2022) · Science Advances · doi:10.1126/sciadv.abg8335 · Cited by 210 · see citing works

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Shabbir, U., Arshad, M. S., Sameen, A., & Oh, D.-H. (2021) · Nutrients · doi:10.3390/nu13020690 · Cited by 191 · see citing works

Dysbiosis of Gut Microbiota from the Perspective of the Gut–Brain Axis: Role in the Provocation of Neurological Disorders

Kandpal, M., Indari, O., Baral, B., Jakhmola, S., Tiwari, D., Bhandari, V., Pandey, R. K., Bala, K., Sonawane, A., & Jha, H. C. (2022) · Metabolites · doi:10.3390/metabo12111064 · Cited by 172 · see citing works

The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review

Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 182 · see citing works

TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury

Wang, Y., Liang, J., Xu, B., Yang, J., Wu, Z., & Cheng, L. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122282 · Cited by 152 · see citing works

Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications

Kim, H. S., Kim, S., Shin, S. J., Park, Y. H., Nam, Y., Lee, K. W., Lee, K. W., Kim, S., Yang, H. D., Yang, H. D., et al. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00273-y · Cited by 161 · see citing works

Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease

Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works

The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

Liu, Y., Tan, Y., Zhang, Z., Yi, M., Zhu, L., & Peng, W. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00397-x · Cited by 144 · see citing works

Brain macrophage development, diversity and dysregulation in health and disease

Silvin, A., Qian, J., & Ginhoux, F. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-01053-6 · Cited by 137 · see citing works

Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease

Sharma, C., & Kim, S. R. (2021) · Antioxidants · doi:10.3390/antiox10081231 · Cited by 136 · see citing works

Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer’s disease

Xu, Y., Jiang, C., Wu, J., Liu, P., Deng, X., Zhang, Y., Peng, B., & Zhu, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13779 · Cited by 122 · see citing works

The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders

Numakawa, T., & Kajihara, R. (2025) · Molecules · doi:10.3390/molecules30040848 · Cited by 111 · see citing works

Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease

Shukla, P. K., Delotterie, D. F., Xiao, J., Pierre, J. F., Rao, R., McDonald, M. P., & Khan, M. M. (2021) · Cells · doi:10.3390/cells10040779 · Cited by 103 · see citing works

The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease?

Parodi, B., & de Rosbo, N. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718220 · Cited by 105 · see citing works

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

Shahbazi, R., Yasavoli‐Sharahi, H., Alsadi, N., Ismail, N., & Matar, C. (2020) · Molecules · doi:10.3390/molecules25214891 · Cited by 101 · see citing works

Alzheimer’s disease as type 3 diabetes: understanding the link and implications

Kciuk, M., Kruczkowska, W., Gałęziewska, J., Wanke, K., Kałuzińska-Kołat, Ż., Aleksandrowicz, M., & Kontek, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211955 · Cited by 98 · see citing works

A monomeric polysaccharide from Polygonatum sibiricum improves cognitive functions in a model of Alzheimer's disease by reshaping the gut microbiota

Luo, S., Zhang, X., Huang, S. Q., Feng, X., Zhang, X., & Xiang, D.-X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.05.185 · Cited by 92 · see citing works

Interactions between central nervous system and peripheral metabolic organs

Zeng, W., Yang, F., Shen, W. L., Zhan, C., Zheng, P., & Hu, J. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2103-5 · Cited by 96 · see citing works

The modulatory effect and implication of gut microbiota on osteoporosis: from the perspective of “brain–gut–bone” axis

Zhang, Y., Li, Y., Lu, P., Dai, G.-C., Chen, X.-X., & Rui, Y. (2021) · Food & Function · doi:10.1039/d0fo03468a · Cited by 88 · see citing works

Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice

Ma, P., Mo, R.-F., Liao, H., Qiu, C., Wu, G., Yang, C., Zhang, Y., Zhao, Y. V., & Song, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02523-w · Cited by 87 · see citing works

Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects

Chu, C., Yu, L., Qi, G., Mi, Y., Wu, W., Lee, Y. K., Zhai, Q., Tian, F., & Chen, W. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104556 · Cited by 85 · see citing works

Advances in Brain–Gut–Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications

Dong, T. S., & Mayer, E. A. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.024 · Cited by 84 · see citing works

Bile Acids, Their Receptors, and the Gut Microbiota

Poland, J. C., & Flynn, C. R. (2021) · Physiology · doi:10.1152/physiol.00028.2020 · Cited by 85 · see citing works

Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients

Zhang, Y., Shen, Y., Liufu, N., Liu, L., Li, W., Shi, Z., Zheng, H., Mei, X., Chen, C.-Y., Jiang, Z., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02216-7 · Cited by 83 · see citing works

Gut Microbiota Dysbiosis as One Cause of Osteoporosis by Impairing Intestinal Barrier Function

Wang, N., Ma, S., & Fu, L. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00911-7 · Cited by 80 · see citing works

Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders

Padhi, P., Worth, C., Zenitsky, G. D., Jin, H., Sambamurti, K., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.836605 · Cited by 80 · see citing works

Gut microbiota and microbial metabolites for osteoporosis

Zheng, X.-Q., Wang, D.-B., Jiang, Y., & Song, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2437247 · Cited by 89 · see citing works

Immune Activation in Alzheimer Disease

Mary, A., Mancuso, R., & Heneka, M. T. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-035222 · Cited by 79 · see citing works

Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models

Carranza-Naval, M. J., Vargas-Soria, M., Hierro‐Bujalance, C., Baena‐Nieto, G., Garcı́a-Alloza, M., Infante‐Garcia, C., & del Marco, À. (2021) · Biomolecules · doi:10.3390/biom11020262 · Cited by 73 · see citing works

The Molecular Pathophysiology of Psoriatic Arthritis—The Complex Interplay Between Genetic Predisposition, Epigenetics Factors, and the Microbiome

Carvalho, A. L., & Hedrich, C. M. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.662047 · Cited by 72 · see citing works

Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway

Xu, Q., Su, Z., Yang, W., Zhong, M., Xian, Y., & Lin, Z. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02704-1 · Cited by 72 · see citing works

Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

Liu, X., Liu, Y., Liu, J., Zhang, H., Shan, C., Guo, Y., Gong, X., Cui, M., Li, X., & Tang, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382223 · Cited by 69 · see citing works

Bile acid receptors and signaling crosstalk in the liver, gut and brain

Ferrell, J. M., & Chiang, J. Y. L. (2021) · Liver Research · doi:10.1016/j.livres.2021.07.002 · Cited by 69 · see citing works

The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

Liang, Y., Liu, C., Cheng, M., Geng, L., Li, J., Du, W., Song, M., Chen, N., Yeleen, T. A. N., Li, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14057 · Cited by 70 · see citing works

Fecal microbiota transplantation mitigates bone loss by improving gut microbiome composition and gut barrier function in aged rats

Ma, S., Wang, N., Zhang, P., Wu, W., & Fu, L. (2021) · PeerJ · doi:10.7717/peerj.12293 · Cited by 66 · see citing works

Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut–Brain Axis

Liu, Q. F., Xie, T., Xi, Y., Li, L., Mo, F., Liu, X., Liu, Z., Gao, J., & Yuan, T. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04687 · Cited by 65 · see citing works

Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

Luo, Y., Yang, L.-L., & Yao, X. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00720-0 · Cited by 70 · see citing works

Functional Amyloids Are the Rule Rather Than the Exception in Cellular Biology

Balistreri, A., Goetzler, E., & Chapman, M. R. (2020) · Microorganisms · doi:10.3390/microorganisms8121951 · Cited by 62 · see citing works

Association Between Oral Bacteria and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Liu, S., Dashper, S. G., & Zhao, R. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220627 · Cited by 61 · see citing works

From Dysbiosis to Neurodegenerative Diseases through Different Communication Pathways: An Overview

Intili, G., Paladino, L., Rappa, F., Alberti, G., Plicato, A., Calabrò, F., Fucarino, A., Cappello, F., Bucchieri, F., Tomasello, G., et al. (2023) · Biology · doi:10.3390/biology12020195 · Cited by 61 · see citing works

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Chandra, S., Di Meco, A., Dodiya, H. B., Popovic, J., Cuddy, L. K., Weigle, I. Q., Zhang, X., Sadleir, K., Sisodia, S. S., & Vassar, R. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00635-2 · Cited by 58 · see citing works

7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development

Yang, S., & Zhu, G. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210915122820 · Cited by 55 · see citing works

Phytonutrients: Sources, bioavailability, interaction with gut microbiota, and their impacts on human health

Kan, J., Wu, F., Wang, F., Zheng, J., Cheng, J., Li, Y., Yang, Y., & Du, J. C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.960309 · Cited by 53 · see citing works

Microglia and gut microbiota: A double-edged sword in Alzheimer's disease

Bano, N., Khan, S., Ahamad, S., Kanshana, J. S., Dar, N. J., Khan, S. J., Nazir, A., & Bhat, S. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102515 · Cited by 49 · see citing works

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

Xiong, J., Liao, J., Liu, X., Zhang, Z., Adams, J., Pacifici, R., & Ye, K. (2022) · Nature Communications · doi:10.1038/s41467-022-32435-5 · Cited by 46 · see citing works

Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored

Kapoor, B., Biswas, P., Gulati, M., Rani, P., & Gupta, R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102570 · Cited by 46 · see citing works

Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery

Liu, N., Yang, C., Liang, X., Cao, K., Xie, J., Luo, Q., & Luo, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01642-z · Cited by 45 · see citing works

Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer’s Disease Pathologies

Borsom, E. M., Conn, K. A., Keefe, C. R., Herman, C., Orsini, G. M., Hirsch, A. H., Avila, M. P., Testo, G., Jaramillo, S. A., Bolyen, E. K., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03458-22 · Cited by 45 · see citing works

Anthocyanins from Lycium ruthenicum Murray Ameliorated High-Fructose Diet-Induced Neuroinflammation through the Promotion of the Integrity of the Intestinal Barrier and the Proliferation of Lactobacillus

Peng, Y., Dong, W., Chen, G., Mi, J., Lu, L., Xie, Z., Xu, W., Zhou, W., Sun, Y., Zeng, X., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06713 · Cited by 46 · see citing works

The complex relationship between gut microbiota and Alzheimer’s disease: A systematic review

Zhou, X.-P., Sun, L.-B., Liu, W., Zhu, W.-M., Li, L.-C., Song, X., Xing, J.-P., & Gao, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102637 · Cited by 50 · see citing works

Xanthoceraside exerts anti-Alzheimer's disease effect by remodeling gut microbiota and modulating microbial-derived metabolites level in rats

Zhou, H., Zhao, J., Liu, C., Zhang, Z., Zhang, Y., & Meng, D. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153937 · Cited by 44 · see citing works

Lactate-utilizing bacteria ameliorates DSS-induced colitis in mice

Chen, L., Li, R., Wang, Z., Zhang, Z., Wang, J., Qiao, Y., Huang, Y., & Liu, W. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120179 · Cited by 43 · see citing works

Organophosphate Insecticide Malathion Induces Alzheimer’s Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis

Cui, J., Xiao, S., Cao, Y., Zhang, Y., Yang, J., Zheng, L., Zhao, F., Liu, X., Liu, D., Zhou, Z., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c07427 · Cited by 41 · see citing works

Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer’s disease animal model

Jiang, J. H., Liu, H., Wang, Z., Tian, H., Wang, S., Yang, J., & Ren, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259530 · Cited by 39 · see citing works

Gut microbiota dysbiosis in Alzheimer's disease (AD): Insights from human clinical studies and the mouse AD models

Manfredi, J. N., Gupta, S. K., Vyavahare, S. S., Deák, F., Lu, X., Buddha, L., Wankhade, U. D., Lohakare, J., Isales, C. M., & Fulzele, S. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114778 · Cited by 38 · see citing works

Lactobacillus rhamnosus zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice via regulating the intestinal microenvironment

Xu, J., Tang, M., Wu, X., Kong, X., Liu, Y., & Xu, X. (2022) · Food & Function · doi:10.1039/d1fo03804d · Cited by 38 · see citing works

BDNF/proBDNF Interplay in the Mediation of Neuronal Apoptotic Mechanisms in Neurodegenerative Diseases

Mitrović, M. M., Selaković, D., Jovicic, N. U., Ljujić, B., & Rosic, G. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104926 · Cited by 41 · see citing works

Sex-Dependent Effects of Intestinal Microbiome Manipulation in a Mouse Model of Alzheimer’s Disease

Kaur, H., Nookala, S., Singh, S., Mukundan, S., Nagamoto‐Combs, K., & Combs, C. K. (2021) · Cells · doi:10.3390/cells10092370 · Cited by 34 · see citing works

Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot study

Lee, J. J., Piras, E., Tamburini, S., Bu, K., Wallach, D. S., Remsen, B., Cantor, A., Kong, J., Goetz, D. M., Hoffman, K. W., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115279 · Cited by 35 · see citing works

Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A systematic review

Chatterjee, A., Kumar, S., Sarkar, S. R., Halder, R., Kumari, R., Banerjee, S., & Sarkar, B. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109622 · Cited by 36 · see citing works

C/EBPβ/AEP Signaling Drives Alzheimer’s Disease Pathogenesis

Xiong, J., Zhang, Z., & Ye, K. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01025-w · Cited by 37 · see citing works

Fecal Microbiota Transplantation Improves Cognitive Function of a Mouse Model of Alzheimer's Disease

Jiang, X., Zheng, Y., Sun, H., Dang, Y., Yin, M., Xiao, M., & Wu, T. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70259 · Cited by 35 · see citing works

Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones

Wu, Y., Hang, Z., Tong, L., & Du, H. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03784-w · Cited by 34 · see citing works

Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study

Zheng, J., Ni, C., Zhang, Y., Huang, J., Hukportie, D. N., Liang, B., & Tang, S. (2023) · BMC Medicine · doi:10.1186/s12916-023-02816-8 · Cited by 33 · see citing works

Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease

Qu, C. F., Xu, Q., Yang, W., Zhong, M., Yuan, Q., Xian, Y., & Lin, Z. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.07.014 · Cited by 33 · see citing works

Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer’s Disease

Song, M., Zhang, S., Gan, Y., Ding, T., Zhu, L., & Fan, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c01042 · Cited by 33 · see citing works

The emerging role of microbiota derived SCFAs in neurodegenerative disorders

Wachamo, S., & Gaultier, A. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101012 · Cited by 34 · see citing works

Current Alzheimer disease research highlights: evidence for novel risk factors

Brenowitz, W. D., Xiang, Y., McEvoy, C. T., Yang, C., Yaffe, K. S., Le, W., & Leng, Y. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001706 · Cited by 32 · see citing works

A Systematic Review on the Effects of Different Types of Probiotics in Animal Alzheimer's Disease Studies

de Rijke, T. J., Doting, M. H. E., van Hemert, S., Deyn, P. P. D., Munster, B. C. V., Harmsen, H. J. M., & Sommer, I. E. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.879491 · Cited by 32 · see citing works

GLP-1 Analogs, SGLT-2, and DPP-4 Inhibitors: A Triad of Hope for Alzheimer’s Disease Therapy

Złotek, M., Kurowska, A., Herbet, M., & Piątkowska‐Chmiel, I. (2023) · Biomedicines · doi:10.3390/biomedicines11113035 · Cited by 30 · see citing works

Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease

Fontdevila, L., Povedano, M., Domínguez, R., Boada, J., Serrano, J. C. E., Pamplona, R., Ayala, V., & Portero‐Otín, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-75083-z · Cited by 29 · see citing works

Gut microbiota, pathogenic proteins and neurodegenerative diseases

Wei, W., Wang, S., Xu, C., Zhou, X., Lian, X., He, L., & Li, K. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.959856 · Cited by 29 · see citing works

Amyloid-β mediates intestinal dysfunction and enteric neurons loss in Alzheimer's disease transgenic mouse

Liu, G., Yu, Q., Zhu, H., Tan, B., Yu, H., Li, X., Lu, Y., & Li, H. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04948-9 · Cited by 27 · see citing works

Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice

Zhao, Z., Fan, X., Gu, Y., Han, J., Jia, Y., Ye, K., & Zhang, Y. Q. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101149 · Cited by 27 · see citing works

AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments

Zhang, W., Cao, L., Yang, J., Zhang, S., Zhao, J., Shi, Z., Liao, K., Wang, H., Chen, B., Qian, Z., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci173299 · Cited by 26 · see citing works

Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease

Susmitha, G., & Kumar, R. K. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109478 · Cited by 26 · see citing works

An integrated neuroimaging-omics approach for the gut-brain communication pathways in Alzheimer’s disease

Sheng, C., Du, W., Liang, Y., Xu, P., Ding, Q., Chen, X., Jia, S., & Wang, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1211979 · Cited by 25 · see citing works

Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice

Huang, P.-Y., Yang, Y., Wang, C., Hsiao, P., Chiang, H., & Chen, T.-W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179626 · Cited by 24 · see citing works

Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies

Liang, J., Wang, Y., Liu, B., Dong, X., Cai, W., Zhang, N., & Zhang, H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14704 · Cited by 27 · see citing works

A Comprehensive Review of the Role of the Microbiota–Gut–Brain Axis via Neuroinflammation: Advances and Therapeutic Implications for Ischemic Stroke

Guo, H., Tang, X., He, X., Weng, Y., Zhang, Q., Fang, Q., & Zhang, L. (2025) · Biomolecules · doi:10.3390/biom15070920 · Cited by 27 · see citing works

Gut Microbiota as a Hidden Player in the Pathogenesis of Alzheimer’s Disease

Choi, H., Lee, D., & Mook‐Jung, I. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215235 · Cited by 23 · see citing works

Alterations of gut microbiota are associated with brain structural changes in the spectrum of Alzheimer's disease: the SILCODE study in Hainan cohort

He, B., Sheng, C., Yu, X., Zhang, L., Chen, F., & Han, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1216509 · Cited by 23 · see citing works

Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson’s disease

Ahn, E. H., Liu, X., Alam, A. M., Kang, S. S., & Ye, K. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01910-2 · Cited by 22 · see citing works

Decoding the Gut Microbiome in Companion Animals: Impacts and Innovations

Shah, H., Trivedi, M. H., Gurjar, T., Sahoo, D. K., Jergens, A. E., Yadav, V. K., Patel, A., & Pandya, P. (2024) · Microorganisms · doi:10.3390/microorganisms12091831 · Cited by 22 · see citing works

Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer’s disease

Zhao, Y., Zhao, W., Chai, X., Sun, P., Huang, J., Guo, X., Zhang, L., Ren, D., Yi, C., Zhu, X., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.04.025 · Cited by 21 · see citing works

Lipopolysaccharide-producing Veillonella infantium and Escherichia fergusonii cause vagus nerve-mediated cognitive impairment in mice

Ma, X., Kim, J.-K., Shin, Y.-J., Park, H.-S., Lee, D.-Y., Yim, S., & Kim, D. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.031 · Cited by 20 · see citing works

Gut Microbiome in Alzheimer’s Disease: from Mice to Humans

Liang, C., Pereira, R., Zhang, Y., & Rojas, O. L. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240308090741 · Cited by 25 · see citing works

Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?

Zhang, S., Lu, J., Jin, Z., Xu, H., Zhang, D., Chen, J., & Wang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1459655 · Cited by 24 · see citing works

Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer’s Disease Model Mice and the SH-SY5Y Neuronal Cell Line

Webberley, T. S., Bevan, R. J., Kerry-Smith, J., Dally, J., Michael, D. R., Thomas, S., Rees, M. E., Morgan, J. E., Marchesi, J. R., Good, M. A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054683 · Cited by 19 · see citing works

Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer’s Disease Model Mice

Nguyen, V. T. T., Brücker, L., Volz, A.-K., Baumgärtner, J. C., dos Santos Guilherme, M., Valeri, F., May-Simera, H., & Endres, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413564 · Cited by 16 · see citing works

Role of gut-microbiota in disease severity and clinical outcomes

Yadav, M., & Chauhan, N. S. (2022) · Briefings in Functional Genomics · doi:10.1093/bfgp/elac037 · Cited by 18 · see citing works

Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer’s and Parkinson’s diseases as druggable targets through Withania somnifera bioactives: an in silico study

Shukla, R., Pahal, S., Gupta, A., Choudhary, P., Misra, K., & Singh, S. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2068072 · Cited by 18 · see citing works

Gut Dysbiosis Activates C/EBPβ/AEP Pathway in Alzheimer’s Disease Mouse Model

Li, K. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/pgz02551

Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease

Chen, C., Zhou, Y., Wang, H., Alam, A. M., Kang, S. S., Ahn, E. H., Liu, X., Jia, J., & Ye, K. (2021) · The EMBO Journal · doi:10.15252/embj.2020106320 · Cited by 137 · see citing works

Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice

Honarpisheh, P., Reynolds, C. R., Conesa, M. P. B., Moruno-Manchon, J. F., Putluri, N., Bhattacharjee, M. B., Urayama, A., McCullough, L. D., & Ganesh, B. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051711 · Cited by 127 · see citing works

Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice

Xia, Y., Xiao, Y., Wang, Z.-H., Liu, X., Alam, A. M., Haran, J. P., McCormick, B. A., Shu, X., Wang, X., & Ye, K. (2023) · Nature Communications · doi:10.1038/s41467-023-41283-w · Cited by 108 · see citing works

Dysbiosis of gut microbiota synergizes with the activation of enteric glial cells to promote Alzheimer's disease

Sun, Q., Li, Y., Wang, Y., Tao, S.-S., Huan, X., Li, Y.-Q., & Zhang, H. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261441247