Bakkenist, Christopher J.

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 3,466

Initiating Cellular Stress Responses

Bakkenist, C. J., & Kastan, M. B. (2004) · Cell

DNA Repair MechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 544

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation

Vendetti, F. P., Karukonda, P., Clump, D. A., Teo, T., Lalonde, R., Nugent, K., Ballew, M., Kiesel, B. F., Beumer, J. H., Sarkar, S. N., et al. (2018) · Journal of Clinical Investigation

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 198

Few-shot learning creates predictive models of drug response that translate from high-throughput screens to individual patients

Ma, J., Fong, S. H., Luo, Y., Bakkenist, C. J., Shen, J. P., Mourragui, S., Wessels, L. F. A., Hafner, M., Sharan, R., Peng, J., et al. (2021) · Nature Cancer

Computational Drug Discovery MethodsDomain Adaptation and Few-Shot Learning

Cited by 180

Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells

Bakkenist, C. J., Drissi, R., Wu, J., Kastan, M. B., & Dome, J. S. (2004) · Cancer Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 68

Transient ATM Kinase Inhibition Disrupts DNA Damage–Induced Sister Chromatid Exchange

White, J. S., Choi, S., & Bakkenist, C. J. (2010) · Science Signaling

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 66

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

White, J. S., Choi, S., & Bakkenist, C. J. (2008) · Cell Cycle

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 51