Transient ATM Kinase Inhibition Disrupts DNA Damage–Induced Sister Chromatid Exchange
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Radiation triggers distinct responses in cells in which the kinase ATM is transiently inhibited versus those that have adapted to its loss.
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Transient inhibition of ATM for one hour increases chromosome aberrations after γIR.
“transient inhibition of ATM for one hour led to increased chromosome aberrations following γIR.48,49”
From Mdmx promotes genomic instability independent of p53 and Mdm2 (2015) · cites this paper as [49]
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Mdmx promotes genomic instability independent of p53 and Mdm2
Carrillo, A. M., Bouska, A., Arrate, M. P., & Eischen, C. M. (2015) · Oncogene · doi:10.1038/onc.2014.27 · Cited by 69 · see citing works
- Authors
- White, J. S., Choi, S., & Bakkenist, C. J.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- White, Jason S.
- Bakkenist, Christopher J.
- Venue
- Science Signaling
- Published
- 2010-06
- Volume
- 3
- Issue
- 124
- Pages
- ra44-ra44
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3261617
- OpenAlex
- W2005939114
- Cited by
- 66
- References
- 60
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2021: 2 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 7
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50CA090440)
- National Institute of General Medical Sciences (T32GM008424)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- ATM kinase, ataxia telangiectasia, sister chromatid exchange, DNA damage response, ionizing radiation, DNA-dependent protein kinase, non-homologous end joining, DNA repair, cell cycle checkpoints, radiosensitivity, chromosomal abnormalities, cell death, ATM kinase inhibitor, fibroblasts
- MeSH terms
- Cell Line, Transformed, Chromosome Aberrations, Chromosomes, Human, DNA Damage, DNA-Binding Proteins, Fibroblasts, Gamma Rays, Humans, Radiation Tolerance, Sister Chromatid Exchange, Cell Death, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Tumor Suppressor Proteins, Protein Kinase Inhibitors, DNA-Activated Protein Kinase, Ataxia Telangiectasia Mutated Proteins
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