Kühn, Ralf

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 1,783

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

Piwecka, M., Glažar, P., Hernandez-Miranda, L. R., Memczak, S., Wolf, S. A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C. A., Fenske, P., et al. (2017) · Science

Circular RNAs in diseasesRNA Research and Splicing

Cited by 1,210

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Chu, V. T., Weber, T., Wefers, B., Wurst, W., Sander, S., Rajewsky, K., & Kühn, R. (2015) · Nature Biotechnology

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 1,210

Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron

Nerve injury and regenerationNeuroscience and Neuropharmacology Research

Cited by 799

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

Davidson, N. J., Leach, M. W., Fort, M. M., Thompson-Snipes, L., Kühn, R., Müller, W., Berg, D. J., & Rennick, D. M. (1996) · The Journal of experimental medicine

Inflammatory Bowel DiseaseT-cell and B-cell Immunology

Cited by 402

Inducible gene deletion in astroglia and radial glia—A valuable tool for functional and lineage analysis

Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 398

Development of an intein-mediated split-Cas9 system for gene therapy

Truong, D.-J. J., Kühner, K., Kühn, R., Werfel, S., Engelhardt, S., Wurst, W., & Ortiz, O. (2015) · Nucleic Acids Research

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 371

IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF- beta and IL-4, and is inhibited by IFN-gamma.

Schmitt, E., Germann, T., Goedert, S., Hoehn, P., Huels, C., Koelsch, S., Kühn, R., Müller, W., Palm, N., & Rüde, E. (1994) · The Journal of Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 299

Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs

Meyer, K., Kirchner, M., Uyar, B., Cheng, J.-Y., Russo, G., Hernandez-Miranda, L. R., Szymborska, A., Zauber, H., Rudolph, I.-M., Willnow, T. E., et al. (2018) · Cell

Protein Structure and DynamicsCellular transport and secretion

Cited by 132

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

Anania, C., Acemel, R. D., Jedamzick, J., Bolondi, A., Cova, G., Brieske, N., Kühn, R., Wittler, L., Real, F. M., & Lupiáñez, D. G. (2021) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 77

Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells

Tran, N. T., Danner, E., Li, X., Graf, R., Lebedin, M., de la Rosa, K., Kühn, R., Rajewsky, K., & Chu, V. T. (2022) · Science Advances

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 49