Ryan, Dylan G.

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell

Immune cells in cancerMitochondrial Function and Pathology

Cited by 2,291

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature

Genomics, phytochemicals, and oxidative stressImmune cells in cancer

Cited by 1,885

Krebs cycle Reborn in macrophage immunometabolism

Ryan, D. G., & O'Neill, L. A. J. (2020) · Annual Review of Immunology

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 444

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 398

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

Early, J. O., Menon, D., Wyse, C. A., Cervantes-Silva, M. P., Zaslona, Z., Carroll, R. G., Palsson-McDermott, E. M., Angiari, S., Ryan, D. G., Corcoran, S. E., et al. (2018) · Proceedings of the National Academy of Sciences

Circadian rhythm and melatoninGenomics, phytochemicals, and oxidative stress

Cited by 389

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Olagnier, D., Brandtoft, A. M., Gunderstofte, C., Villadsen, N. L., Krapp, C., Thielke, A. L., Laustsen, A., Peri, S., Hansen, A. L., Bonefeld, L., et al. (2018) · Nature Communications

interferon and immune responsesGenomics, phytochemicals, and oxidative stress

Cited by 282

Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models

Drzewicka, K., Głuchowska, K. M., Mlącki, M., Hofman, B., Tuszyńska, I., Ryan, T. A. J., Piwowar, K., Wilczyński, B., Dymkowska, D., Grzybowski, M. M., et al. (2025) · Frontiers in Immunology

Liver Disease Diagnosis and TreatmentStudies on Chitinases and Chitosanases

Cited by 3