Stratton, Margaret M.

Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP

Saneyoshi, T., Matsuno, H., Suzuki, A., Murakoshi, H., Hedrick, N. G., Agnello, E., O’Connell, R., Stratton, M. M., Yasuda, R., & Hayashi, Y. (2019) · Neuron

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

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Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

Stratton, M., Lee, I.-H., Bhattacharyya, M., Christensen, S. M., Chao, L. H., Schulman, H., Groves, J. T., & Kuriyan, J. (2014) · eLife

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

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Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

Bhattacharyya, M., Stratton, M. M., Going, C. C., McSpadden, E. D., Huang, Y., Susa, A. C., Elleman, A., Cao, Y. M., Pappireddi, N., Burkhardt, P., et al. (2016) · eLife

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

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CaMKII binds both substrates and activators at the active site

Özden, C., Sloutsky, R., Mitsugi, T., Santos, N., Agnello, E., Gaubitz, C., Foster, J., Lapinskas, E., Esposito, E. A., Saneyoshi, T., et al. (2022) · Cell Reports

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

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Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer

Yang, X., Ma, X., Zhao, T., Croucher, D. R., Nguyen, E. V., Clark, K. C., Hu, C., Latham, S. L., Bayly-Jones, C., Nguyen, B. V., et al. (2025) · Nature Communications

Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and Therapy

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Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer

Yang, X., Ma, X., Zhao, T., Croucher, D. R., Nguyen, E. V., Clark, K. C., Hu, C., Latham, S. L., Bayly-Jones, C., Nguyen, V. C. B., et al. (2024) · Nature Communications

Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and Therapy

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