Jacks, Tyler

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues

Zhao, T., Chiang, Z. D., Morriss, J. W., LaFave, L. M., Murray, E. M., Del Priore, I., Meli, K., Lareau, C. A., Nadaf, N. M., Li, J., et al. (2022) · Nature

Single-cell and spatial transcriptomicsCancer Genomics and Diagnostics

Cited by 268

Lung adenocarcinoma distally rewires hepatic circadian homeostasis

Masri, S., Papagiannakopoulos, T., Kinouchi, K., Liu, Y., Cervantes, M., Baldi, P., Jacks, T., & Sassone-Corsi, P. (2016) · Cell

Circadian rhythm and melatoninMetabolism, Diabetes, and Cancer

Cited by 234

Cell type-specific effects of Rb deletion in the murine retina

MacPherson, D., Sage, J., Kim, T., Ho, D., McLaughlin, M. E., & Jacks, T. (2004) · Genes & Development

Retinal Development and DisordersOcular Oncology and Treatments

Cited by 222

Mutational landscape of EGFR- , MYC- , and Kras- driven genetically engineered mouse models of lung adenocarcinoma

McFadden, D. G., Politi, K., Bhutkar, A., Chen, F. K., Song, X., Pirun, M., Santiago, P. M., Kim-Kiselak, C., Platt, J. T., Lee, E., et al. (2016) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsLung Cancer Treatments and Mutations

Cited by 194

Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy

Doles, J., Oliver, T. G., Cameron, E. R., Hsu, G., Jacks, T., Walker, G. C., & Hemann, M. T. (2010) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsMetal complexes synthesis and properties

Cited by 190

Survival of pancreatic cancer cells lacking KRAS function

Muzumdar, M. D., Chen, P.-Y., Dorans, K. J., Chung, K. M., Bhutkar, A., Hong, E., Noll, E. M., Sprick, M. R., Trumpp, A., & Jacks, T. (2017) · Nature Communications

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 177

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Chung, K. M., Singh, J., Lawres, L., Dorans, K. J., Garcia, C., Burkhardt, D. B., Robbins, R., Bhutkar, A., Cardone, R., Zhao, X., et al. (2020) · Cell

Pancreatic and Hepatic Oncology ResearchCancer, Lipids, and Metabolism

Cited by 150

Nf1 Regulates Hematopoietic Progenitor Cell Growth and Ras Signaling in Response to Multiple Cytokines

Zhang, Y.-Y., Vik, T. A., Ryder, J. W., Srour, E. F., Jacks, T., Shannon, K., & Wade Clapp, D. (1998) · The Journal of Experimental Medicine

Neurofibromatosis and Schwannoma CasesProtein Tyrosine Phosphatases

Cited by 150

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Shaw, A. T., Meissner, A., Dowdle, J. A., Crowley, D., Magendantz, M., Ouyang, C., Parisi, T., Rajagopal, J., Blank, L. J., Bronson, R. T., et al. (2007) · Genes & Development

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 131

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

Faber, A. C., Farago, A. F., Costa, C., Dastur, A., Gomez-Caraballo, M., Robbins, R., Wagner, B. L., Rideout, W. M., Jakubik, C. T., Ham, J., et al. (2015) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationLung Cancer Research Studies

Cited by 127

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

MacPherson, D., Kim, J., Kim, T., Rhee, B. K., van Oostrom, C. T., DiTullio, R. A., Venere, M., Halazonetis, T. D., Bronson, R., de Vries, A., et al. (2004) · The EMBO Journal

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 124

Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389

Bruins, W., Zwart, E., Attardi, L. D., Iwakuma, T., Hoogervorst, E. M., Beems, R. B., Miranda, B., van Oostrom, C. T. M., van den Berg, J., van den Aardweg, G. J., et al. (2004) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 121

For Better or Worse? Telomerase Inhibition and Cancer

de Lange, T., & Jacks, T. (1999) · Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 119

Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types

Ihrie, R. A., Reczek, E., Horner, J. S., Khachatrian, L., Sage, J., Jacks, T., & Attardi, L. D. (2003) · Current Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 118

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Muzumdar, M. D., Dorans, K. J., Chung, K. M., Robbins, R., Tammela, T., Gocheva, V., Li, C. M.-C., & Jacks, T. (2016) · Nature Communications

Cancer Genomics and DiagnosticsCancer-related Molecular Pathways

Cited by 72

The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain

Hajal, C., Shin, Y., Li, L., Serrano, J. C., Jacks, T., & Kamm, R. D. (2021) · Science Advances

Barrier Structure and Function StudiesChemokine receptors and signaling

Cited by 69

Comparison of gene expression and DNA copy number changes in a murine model of lung cancer

Sweet‐Cordero, A., Tseng, G. C., You, H., Douglass, M., Huey, B., Albertson, D., & Jacks, T. (2006) · Genes, Chromosomes and Cancer

Cancer Genomics and DiagnosticsGenomic variations and chromosomal abnormalities

Cited by 45