For Better or Worse? Telomerase Inhibition and Cancer

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804 · see citing works

A survey of telomerase activity in human cancer

Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794 · see citing works

The RNA Component of Human Telomerase

Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227 · see citing works

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · see citing works

Untitled work

Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works

TRF2 Protects Human Telomeres from End-to-End Fusions

van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709 · see citing works

Origin of Concatemeric T7DNA

WATSON, J. D. (1972) · Nature New Biology · doi:10.1038/newbio239197a0 · Cited by 1,632 · see citing works

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · see citing works

Essential role of mouse telomerase in highly proliferative organs

Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · see citing works

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086 · see citing works

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979 · see citing works

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

Prowse, K. R., & Greider, C. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4818 · Cited by 686 · see citing works

Sugar and Disease

Yudkin, J. S. (1972) · Nature · doi:10.1038/239197a0 · Cited by 543 · see citing works

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

Greenberg, R. A., Chin, L., Femino, A., Lee, K.-H., Gottlieb, G. J., Singer, R. H., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80761-8 · Cited by 367 · see citing works

Functional Characterization and Developmental Regulation of Mouse Telomerase RNA

Blasco, M. A., Funk, W. D., Villeponteau, B., & Greider, C. W. (1995) · Science · doi:10.1126/science.7544492 · Cited by 361 · see citing works

Human telomeres: fusion and interstitial sites

Hastie, N. D., & Allshire, R. C. (1989) · Trends in Genetics · doi:10.1016/0168-9525(89)90137-6 · Cited by 243 · see citing works

E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts.

Shay, J. W., Wright, W. E., Brasiskyte, D., & Haegen, B. A. (1993) · PubMed · Cited by 201 · see citing works

The Telomere Lengthening Mechanism in Telomerase-Negative Immortal Human Cells Does Not Involve the Telomerase RNA Subunit

Bryan, T. M., Marusic, L., Bacchetti, S., Namba, M., & Reddel, R. R. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.6.921 · Cited by 192 · see citing works

Severe growth defect in mouse cells lacking the telomerase RNA component

Niida, H., Matsumoto, T., Satoh, H., Shiwa, M., Tokutake, Y., Furuichi, Y., & Shinkai, Y. (1998) · Nature Genetics · doi:10.1038/580 · Cited by 156 · see citing works

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

Blackburn, E. H., Greider, C. W., & Szostak, J. W. (2006) · Nature Medicine · doi:10.1038/nm1006-1133 · Cited by 992 · see citing works

Mechanism-Based Target Identification and Drug Discovery in Cancer Research

Gibbs, W. W. (2000) · Science · doi:10.1126/science.287.5460.1969 · Cited by 599 · see citing works

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

Herbert, B.-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., & Corey, D. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14276 · Cited by 539 · see citing works

Telomerase and cancer

Shay, J. W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.677 · Cited by 517 · see citing works

Replication and protection of telomeres

Verdun, R. E., & Karlseder, J. (2007) · Nature · doi:10.1038/nature05976 · Cited by 463 · see citing works

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

Wright, W. E., & Shay, J. W. (2000) · Nature Medicine · doi:10.1038/78592 · Cited by 398 · see citing works

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

González-Suárez, E., Samper, E., Flores, J. M., & Blasco, M. A. (2000) · Nature Genetics · doi:10.1038/79089 · Cited by 347 · see citing works

Animal Cell Cytokinesis

Glotzer, M. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.351 · Cited by 342 · see citing works

Telomerase: A target for cancer therapeutics

Shay, J. W., & Wright, W. E. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00159-9 · Cited by 330 · see citing works

A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis

Tefferi, A., Lasho, T. L., Begna, K. H., Patnaik, M. M., Zblewski, D., Finke, C. M., Laborde, R. R., Wassie, E. A., Schimek, L., Hanson, C. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1310523 · Cited by 324 · see citing works

A critical role for telomeres in suppressing and facilitating carcinogenesis

Artandi, S. E., & DePinho, R. A. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00047-7 · Cited by 318 · see citing works

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

Davoli, T., Denchi, E. L., & de Lange, T. (2010) · Cell · doi:10.1016/j.cell.2010.01.031 · Cited by 298 · see citing works

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

Salvati, E., Leonetti, C., Rizzo, A., Scarsella, M., Mottolese, M., Galati, R., Sperduti, I., Stevens, M. F. G., D’Incalci, M., Blasco, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32461 · Cited by 266 · see citing works

Repetitive Elements in Mammalian Telomeres Suppress Bacterial DNA-Induced Immune Activation

Gürsel, İ., Gürsel, M., Yamada, H., Ishii, K. J., Takeshita, F., & Klinman, D. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1393 · Cited by 240 · see citing works

Wild-derived inbred mouse strains have short telomeres

Hemann, M. T. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.22.4474 · Cited by 227 · see citing works

Living with Genome Instability: Plant Responses to Telomere Dysfunction

Říha, K., McKnight, T. D., Griffing, L. R., & Shippen, D. E. (2001) · Science · doi:10.1126/science.1057110 · Cited by 226 · see citing works

TERT regulates cell survival independent of telomerase enzymatic activity

Cao, Y., He, L., Deb, S., & Liu, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205419 · Cited by 214 · see citing works

Position Statement on Human Aging

Olshansky, S. J., Hayflick, L., & Carnes, B. A. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.8.b292 · Cited by 202 · see citing works

Human premature aging, DNA repair and RecQ helicases

Brosh, R. M., & Bohr, V. A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1008 · Cited by 203 · see citing works

Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways

Tauchi, T., Shin‐ya, K., Sashida, G., Sumi, M., Nakajima, A., Shimamoto, T., Ohyashiki, J. H., & Ohyashiki, K. (2003) · Oncogene · doi:10.1038/sj.onc.1206833 · Cited by 205 · see citing works

The role of stem cells in aging

Zant, G. E. V., & Liang, Y. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00088-2 · Cited by 194 · see citing works

The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing

Young, A. J. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0452 · Cited by 192 · see citing works

Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs

Kim, K.-W., Chung, H.-N., Ha, K.-Y., Lee, J.-S., & Kim, Y. (2009) · The Spine Journal · doi:10.1016/j.spinee.2009.04.018 · Cited by 189 · see citing works

Programmed Death Phenomena: From Organelle to Organism

Skulachev, V. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02095.x · Cited by 171 · see citing works

Functional and dysfunctional roles of quadruplex DNA in cells

Arthanari, H., & Bolton, P. H. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00007-2 · Cited by 159 · see citing works

Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines.

Patry, C., Bouchard, L., Labrecque, P., Gendron, D., Lemieux, B., Toutant, J., Lapointe, E., Wellinger, R. J., & Chabot, B. (2003) · PubMed · Cited by 152 · see citing works

Telomeres and telomerases as drug targets

Rezler, E. M. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00182-0 · Cited by 146 · see citing works

Discovering novel chemotherapeutic drugs for the third millennium

Garrett, M. D., & Workman, P. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00280-4 · Cited by 141 · see citing works

Phenotypes in mTERT+/− and mTERT−/− Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase

Strong, M. A., Vidal-Cardenas, S. L., Karim, B. O., Yu, H. M., Guo, N., & Greider, C. W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05312-11 · Cited by 134 · see citing works

The programmed death phenomena, aging, and the Samurai law of biology

Skulachev, V. P. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00109-7 · Cited by 134 · see citing works

Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.

DiRenzo, J., Signoretti, S., Nakamura, N., Rivera-Gonzalez, R., Sellers, W. R., Loda, M. F., & Brown, M. A. (2002) · PubMed · Cited by 131 · see citing works

Telomere Inhibition and Telomere Disruption as Processes for Drug Targeting

Rezler, E. M., Bearss, D. J., & Hurley, L. H. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135733 · Cited by 125 · see citing works

The illusion of cell immortality

Hayflick, L. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1296 · Cited by 124 · see citing works

DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression

Tong, W., Hande, M. P., Lansdorp, P. M., & Wang, Z. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.4046-4054.2001 · Cited by 121 · see citing works

Porous Covalent Triazine Polymer as a Potential Nanocargo for Cancer Therapy and Imaging

Rengaraj, A., Puthiaraj, P., Haldorai, Y., Heo, N. S., Hwang, S., Han, Y., Kwon, S., Ahn, W., & Huh, Y. S. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00284 · Cited by 106 · see citing works

Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy

Nakajima, A., Tauchi, T., Sashida, G., Sumi, M., Abe, K., Yamamoto, K., Ohyashiki, J. H., & Ohyashiki, K. (2003) · Leukemia · doi:10.1038/sj.leu.2402825 · Cited by 103 · see citing works

Inactivation of hTERT transcription by Tax

Gabet, A., Mortreux, F., Charneau, P., Riou, P., Dodon, M. D., Wu, Y., Jeang, K., & Wattel, E. (2003) · Oncogene · doi:10.1038/sj.onc.1206468 · Cited by 90 · see citing works

Integration of telomere sequences with the draft human genome sequence

Riethman, H. C., Xiang, Z., Paul, S., Morse, E., Hu, X.-L., Jonathan Flint, C., Chi, H.-C., Grady, D. L., & Moyzis, R. K. (2001) · Nature · doi:10.1038/35057180 · Cited by 88 · see citing works

Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase

Liu, X., Zhou, Y., Lou, Y., & Zhong, H. (2015) · Gene · doi:10.1016/j.gene.2015.11.009 · Cited by 76 · see citing works

Dyskeratosis congenita, telomeres and human ageing

Marciniak, R. A., Johnson, F. B., & Guarente, L. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)01984-3 · Cited by 74 · see citing works

Label-free detection of telomerase activity in HeLa cells using electrochemical impedance spectroscopy

Yang, W., Zhu, X., Liu, Q., Lin, Z., Qiu, B., & Chen, G. (2011) · Chemical Communications · doi:10.1039/c0cc05230b · Cited by 72 · see citing works

The significance of human telomerase reverse transcriptase (hTERT) in cancer

Kirkpatrick, K. L., & Mokbel, K. (2001) · European Journal of Surgical Oncology · doi:10.1053/ejso.2001.1151 · Cited by 69 · see citing works

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

Biroccio, A., Rizzo, A., Elli, R., Koering, C.-E., Belleville, A., Benassi, B., Leonetti, C., Stevens, M. F. G., D’Incalci, M., Zupi, G., et al. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.03.010 · Cited by 67 · see citing works

Telomere maintenance mechanisms as a target for drug development

Bearss, D. J., Hurley, L. H., & Hoff, D. D. V. (2000) · Oncogene · doi:10.1038/sj.onc.1204092 · Cited by 67 · see citing works

Structure-activity relationships among guanine-quadruplex telomerase inhibitors

Neidle, S., Harrison, R. J., Reszka, A. P., & Read, M. A. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00065-0 · Cited by 64 · see citing works

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer

Perera, S. A., Maser, R. S., Xia, H., McNamara, K. L., Protopopov, A. I., Chen, L., Hezel, A. F., Kim, C. F., Bronson, R. T., Castrillón, D. H., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn050 · Cited by 57 · see citing works

Detection of activity of telomerase in tumor cells using fiber optical biosensors

Schmidt, P. M., Lehmann, C., Matthes, E., & Bier, F. F. (2002) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(02)00102-1 · Cited by 56 · see citing works

The maintenance and masking of chromosome termini

Bertuch, A. A., & Lundblad, V. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.04.005 · Cited by 52 · see citing works

Cell-cycle dysregulation and the molecular mechanisms of prostate cancer

Derek, F. A. (2000) · Frontiers in bioscience · doi:10.2741/amanatullah · Cited by 53 · see citing works

The Role of Telomerase Expression and Telomere Length Maintenance in Human and Mouse

Nan-PIng, W., & Hodes, R. J. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1017223602293 · Cited by 49 · see citing works

Use of Telomerase to Create Bioengineered Tissues

Shay, J. W., & Wright, W. E. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1356.037 · Cited by 49 · see citing works

Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib, in BCR-ABL-positive leukemia cells.

Tauchi, T., Nakajima, A., Sashida, G., Shimamoto, T., Ohyashiki, J. H., Abe, K., Yamamoto, K., & Ohyashiki, K. (2002) · PubMed · Cited by 51 · see citing works

Structure of stem‐loop IV of Tetrahymena telomerase RNA

Chen, Y., Fender, J. K., Legassie, J. D., Jarstfer, M. B., Bryan, T. M., & Varani, G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601195 · Cited by 47 · see citing works

The programmed aging paradigm: How we get old

Libertini, G. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914100034 · Cited by 46 · see citing works

Do Telomeres Influence Pace‐of‐Life‐Strategies in Response to Environmental Conditions Over a Lifetime and Between Generations?

Giraudeau, M., Angelier, F., & Sepp, T. (2019) · BioEssays · doi:10.1002/bies.201800162 · Cited by 45 · see citing works

Telomeres in ecology and evolution: A review and classification of hypotheses

Tobler, M., Gómez‐Blanco, D., Hegemann, A., Lapa, M., Neto, J. M., Tarka, M., Xiong, Y., & Hasselquist, D. (2021) · Molecular Ecology · doi:10.1111/mec.16308 · Cited by 43 · see citing works

Energetics of Quadruplex-Drug Recognition in Anticancer Therapy

Pagano, B., & Giancola, C. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907781662257 · Cited by 42 · see citing works

Testing telomerase

Marciniak, R. A., & Guarente, L. (2001) · Nature · doi:10.1038/35096663 · Cited by 41 · see citing works

Position Statement on Human Aging

Olshansky, S. J., Hayflick, L., & Carnes, B. A. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.24.pe9 · Cited by 39 · see citing works

Benefits of bad telomeres

Hanahan, D. (2000) · Nature · doi:10.1038/35020662 · Cited by 39 · see citing works

Possible interventions to modify aging

Libertini, G., & Ferrara, N. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916120038 · Cited by 38 · see citing works

Aging and the programmed death phenomena

Skulachev, V. P. (2003) · Topics in current genetics · doi:10.1007/978-3-540-37005-5_8 · Cited by 36 · see citing works

Cell proliferation, carcinogenesis and diverse mechanisms of telomerase regulation

Krupp, G., Klapper, W., & Parwaresch, R. M. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000708 · Cited by 36 · see citing works

Evolutionary Explanations of the “Actuarial Senescence in the Wild” and of the “State of Senility”

Libertini, G. (2006) · The Scientific World JOURNAL · doi:10.1100/tsw.2006.209 · Cited by 31 · see citing works

Phylogeny of aging and related phenoptotic phenomena

Libertini, G. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915120019 · Cited by 31 · see citing works

Activation of p53 protein by telomeric (TTAGGG)n repeats

Milyavsky, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.24.5207 · Cited by 30 · see citing works

INHIBITION OF TELOMERASE IS RELATED TO THE LIFE SPAN AND TUMORIGENICITY OF HUMAN PROSTATE CANCER CELLS

Guo, C., Geverd, D. A., Liao, R. P., Hamad, N. M., Counter, C. M., & PRICE, D. T. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)66045-4 · Cited by 26 · see citing works

Telomerase Activity in Periampullary Tumors Correlates With Aggressive Malignancy

Balcom, J. H., Keck, T., Warshaw, A. L., Antoniu, B. A., Graeme‐Cook, F., & Castillo, C. F. F.-D. (2001) · Annals of Surgery · doi:10.1097/00000658-200109000-00008 · Cited by 26 · see citing works

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs

Kim, K.-W., Ha, K.-Y., Lee, J.-S., Na, K.-H., Kim, Y., & Woo, Y.-K. (2008) · Asian Spine Journal · doi:10.4184/asj.2008.2.1.1 · Cited by 24 · see citing works

Characterization of Oryza sativa telomerase reverse transcriptase and possible role of its phosphorylation in the control of telomerase activity

Oguchi, K., Tamura, K., & Takahashi, H. K. (2004) · Gene · doi:10.1016/j.gene.2004.07.011 · Cited by 23 · see citing works

Use of nanoparticles to deliver immunomodulatory oligonucleotides

Klinman, D. M., Sato, T., & Shimosato, T. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1382 · Cited by 21 · see citing works

Homoharringtonine-Induced Apoptosis of Human Leukemia HL-60 Cells is Associated with Down-Regulation of Telomerase

Xie, W.-Z., Lin, M.-F., Huang, H., & Cai, Z. (2006) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x06003795 · Cited by 19 · see citing works

Methods of studying telomere damage induced by quadruplex-ligand complexes

Rizzo, A., Salvati, E., & Biroccio, A. (2012) · Methods · doi:10.1016/j.ymeth.2012.02.010 · Cited by 18 · see citing works

Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E

Song, Y. S., & Park, Y. J. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.304 · Cited by 19 · see citing works

Telomerase: Not Just Black and White, but Shades of Gray

Liu, J. (2000) · Molecular Cell Biology Research Communications · doi:10.1006/mcbr.2000.0203 · Cited by 17 · see citing works

Combination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line

Fu, X. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i6.785 · Cited by 18 · see citing works

Elimination of Senescent Cells: Prospects According to the Subtelomere-Telomere Theory

Libertini, G., Ferrara, N., Rengo, G., & Corbi, G. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918120064 · Cited by 16 · see citing works

Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes

Argilla, D., Chin, K., Singh, M., Hodgson, J. G., Bosenberg, M., Ortíz-de-Solórzano, C., Lockett, S. J., DePinho, R. A., Gray, J. W., & Hanahan, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.032 · Cited by 16 · see citing works

Transplatin-modified oligonucleotides as modulators of gene expression

Giraud-Panis, M.-J. E., & Leng, M. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00058-3 · Cited by 16 · see citing works

The potential role of chromosome telomere resetting consequent upon sex in the population dynamics of aphids: an hypothesis

Lushai, G., & Loxdale, H. D. (2007) · Biological Journal of the Linnean Society · doi:10.1111/j.1095-8312.2007.00760.x · Cited by 13 · see citing works

Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells transfected with the Ha-ras oncogene

Peitl, P. (2002) · Mutagenesis · doi:10.1093/mutage/17.1.67 · Cited by 13 · see citing works

Why and when should organisms elongate their telomeres? Elaborations on the ‘excess resources elongation’ and ‘last resort elongation’ hypotheses

Gómez‐Blanco, D., Tobler, M., & Hasselquist, D. (2023) · Ecology and Evolution · doi:10.1002/ece3.10825 · Cited by 12 · see citing works

Final checkup of neoplastic DNA replication: evidence for failure in decision-making at the mitotic cell cycle checkpoint G(1)/S.

Prindull, G. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.07.009 · Cited by 11 · see citing works

Telomerase Inhibition Combined with Other Chemotherapeutic Reagents to Enhance Anti-Cancer Effect

Tauchi, T., Ohyashiki, J. H., & Ohyashiki, K. (2007) · Methods in molecular biology · doi:10.1007/978-1-60327-070-0_14 · Cited by 9 · see citing works

Phenoptosis, another specialized neologism, or the mark of a widespread revolution?

Libertini, G. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912070139 · Cited by 8 · see citing works

Translating basic aging research into geriatric health care

Hamerman, D., & Zeleznik, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00200-x · Cited by 7 · see citing works

In vitro aging of rat lung cells

Petitot, F., Lebeau, J., Dano, L., Lectard, B., Altmeyer, S., Levalois, C., & Chevillard, S. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00103-4 · Cited by 7 · see citing works

Telomerase and Cancer

Falchetti, M. L., D, R. P. M., & Levi, A. (2004) · American Journal of Cancer · doi:10.2165/00024669-200403010-00001 · Cited by 3 · see citing works

What can we learn by growing equine cells in culture?

Shepherd, P. R. (2000) · Equine Veterinary Journal · doi:10.2746/042516400777591101 · Cited by 2 · see citing works

The role of telomeres and telomerase in aging and longevity determination

Hayflick, L. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08010-5 · Cited by 2 · see citing works

Phylogeny of age-related fitness decline in the wild and of related phenomena

Libertini, G. (2011) · Cited by 2 · see citing works

Perspectives to Modify and Counter Aging in the Frame of Subtelomere–Telomere Theory of Aging

Libertini, G. (2022) · OBM Geriatrics · doi:10.21926/obm.geriatr.2204208 · Cited by 2 · see citing works

Cellular versus Organismal Aging

Dillin, A. G., & Karlseder, J. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_1 · Cited by 1 · see citing works

The Feasibility and Necessity of a Revolution in Geriatric Medicine

Libertini, G. (2017) · OBM Geriatrics · doi:10.21926/obm.geriatr.1702002 · Cited by 1 · see citing works

Identification and characterization of genes essential for oncolytic Newcastle disease virus replication in human tumor cells

Puhlmann, J. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8053 · Cited by 1 · see citing works

Forward: Aging and cancer: Are telomeres and telomerase the connection?

Shay, J. W., & Wright, W. E. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08001-4 · Cited by 1 · see citing works

Telomeres in Cell Function: Cancer and Ageing

Pardue, M. L., & DeBaryshe, G. (2009) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0001168.pub2 · Cited by 1 · see citing works

Programmed Death Phenomena at Various Levels of Development of the Living Systems

Skulachev, V. P. (2003) · Springer eBooks · doi:10.1007/978-94-010-0064-2_5 · Cited by 1 · see citing works

Molecular genetic studies of vertebrate ecology : the analysis of senescence, offspring sex ratio variation and population diversity

Whitaker, H. (2002) · Enlighten: Theses (The University of Glasgow)

Telomeres, telomerase and cancer: is the magic bullet real?

Hw, S., MALTÉSE, J. ‐., Zhu, X., Kaiser, H. E., & Narayanan, R. (1996) · PubMed · Cited by 28 · see citing works

Telomerase activity in human cancer

Shay, J. W., & Wright, W. E. (1996) · Current Opinion in Oncology · doi:10.1097/00001622-199601000-00012 · Cited by 404 · see citing works

Telomeres and telomerase in oncogenesis (Review)

Trybek, T., Kowalik, A., Góźdź, S. S., & Kowalska, A. (2020) · Oncology Letters · doi:10.3892/ol.2020.11659 · Cited by 126 · see citing works

Telomere dysfunction and telomerase activation in cancer – a pathological paradox?

Calcagnile, O., & Gisselsson, D. (2007) · Cytogenetic and Genome Research · doi:10.1159/000108310 · Cited by 12 · see citing works

The role of telomeres in ageing and cancer.

Sl, M. (1998) · PubMed · Cited by 8 · see citing works