Fu, Haian

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell

Cell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer

Cited by 5,689

Targeting protein–protein interactions as an anticancer strategy

Ivanov, A. A., Khuri, F. R., & Fu, H. (2013) · Trends in Pharmacological Sciences

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 401

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

A CRISPR/Cas9-Engineered ARID1A -Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., et al. (2021) · Cancer Discovery

Chromatin Remodeling and CancerCRISPR and Genetic Engineering

Cited by 174

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

Zhang, Z., Obianyo, O., Dall, E., Du, Y., Fu, H., Liu, X., Kang, S. S., Song, M., Yu, S.-P., Cabrele, C., et al. (2017) · Nature Communications

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 146

Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

Du, Y., Li, X., Niu, Q., Mo, X., Qui, M., Ma, T., Kuo, C. J., & Fu, H. (2020) · Journal of Molecular Cell Biology

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 125

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor

Zhao, J., Du, Y., Horton, J. R., Upadhyay, A. K., Lou, B., Bai, Y., Zhang, X., Du, L., Li, M., Wang, B., et al. (2011) · Proceedings of the National Academy of Sciences

14-3-3 protein interactionsProtein Kinase Regulation and GTPase Signaling

Cited by 105

Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment

Gu, L., Zhang, H., Liu, T., Zhou, S., Du, Y., Xiong, J., Yi, S., Qu, C.-K., Fu, H., & Zhou, M. (2016) · Cancer Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 86

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Chen, G., Luo, Y., Warncke, K., Sun, Y., Yu, D. S., Fu, H., Behera, M., Ramalingam, S. S., Doetsch, P. W., Duong, D. M., et al. (2019) · Nature Communications

Biochemical and Molecular ResearchDNA Repair Mechanisms

Cited by 82