Kvaratskhelia, Mamuka

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Eidahl, J. O., Crowe, B. L., North, J. A., McKee, C. J., Shkriabai, N., Feng, L., Plumb, M., Graham, R. L., Gorelick, R. J., Hess, S., et al. (2013) · Nucleic Acids Research

Genomics and Chromatin DynamicsHIV Research and Treatment

Cited by 207

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Jurado, K. A., Wang, H., Slaughter, A., Feng, L., Kessl, J. J., Koh, Y., Wang, W., Ballandras-Colas, A., Patel, P. A., Fuchs, J. R., et al. (2013) · Proceedings of the National Academy of Sciences

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 203

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Passos, D. O., Li, M., Yang, R., Rebensburg, S. V., Ghirlando, R., Jeon, Y., Shkriabai, N., Kvaratskhelia, M., Craigie, R., & Lyumkis, D. (2017) · Science

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 202

BET proteins promote efficient murine leukemia virus integration at transcription start sites

Sharma, A., Larue, R. C., Plumb, M. R., Malani, N., Male, F., Slaughter, A., Kessl, J. J., Shkriabai, N., Coward, E., Aiyer, S. S., et al. (2013) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 193

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

Kessl, J. J., Kutluay, S. B., Townsend, D., Rebensburg, S., Slaughter, A., Larue, R. C., Shkriabai, N., Bakouche, N., Fuchs, J. R., Bieniasz, P. D., et al. (2016) · Cell

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 152

A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase

Sharma, A., Slaughter, A., Jena, N., Feng, L., Kessl, J. J., Fadel, H. J., Malani, N., Male, F., Wu, L., Poeschla, E., et al. (2014) · PLoS Pathogens

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 124

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Singh, P. K., Plumb, M. R., Ferris, A. L., Iben, J. R., Wu, X., Fadel, H. J., Luke, B. T., Esnault, C., Poeschla, E. M., Hughes, S. H., et al. (2015) · Genes & Development

Virus-based gene therapy researchRNA Research and Splicing

Cited by 109

Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A

Shell, S. M., Li, Z., Shkriabai, N., Kvaratskhelia, M., Brosey, C., Serrano, M. A., Chazin, W. J., Musich, P. R., & Zou, Y. (2009) · Journal of Biological Chemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 86

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

Crowe, B. L., Larue, R. C., Yuan, C., Hess, S., Kvaratskhelia, M., & Foster, M. P. (2016) · Proceedings of the National Academy of Sciences

Protein Degradation and InhibitorsGenomics and Chromatin Dynamics

Cited by 83

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

Aiyer, S., Swapna, G. V. T., Malani, N., Aramini, J. M., Schneider, W. M., Plumb, M. R., Ghanem, M., Larue, R. C., Sharma, A., Studamire, B., et al. (2014) · Nucleic Acids Research

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 72

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

Elliott, J. L., Eschbach, J. E., Koneru, P. C., Li, W., Puray-Chavez, M., Townsend, D., Lawson, D. Q., Engelman, A. N., Kvaratskhelia, M., & Kutluay, S. B. (2020) · eLife

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 59

Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells

Raghavendra, N. K., Shkriabai, N., Graham, R. L., Hess, S., Kvaratskhelia, M., & Wu, L. (2010) · Retrovirology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 56

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

Kessl, J. J., Eidahl, J. O., Shkriabai, N., Zhao, Z., McKee, C. J., Hess, S., Burke, T. R., & Kvaratskhelia, M. (2009) · Molecular Pharmacology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 50

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

Koneru, P. C., Francis, A. C., Deng, N., Rebensburg, S. V., Hoyte, A. C., Lindenberger, J., Adu-Ampratwum, D., Larue, R. C., Wempe, M. F., Engelman, A. N., et al. (2019) · eLife

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 49

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

Larue, R. C., Plumb, M. R., Crowe, B. L., Shkriabai, N., Sharma, A., DiFiore, J., Malani, N., Aiyer, S. S., Roth, M. J., Bushman, F. D., et al. (2014) · Nucleic Acids Research

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 44

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

Feng, L., Dharmarajan, V., Serrao, E., Hoyte, A., Larue, R. C., Slaughter, A., Sharma, A., Plumb, M. R., Kessl, J. J., Fuchs, J. R., et al. (2016) · ACS Chemical Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 37

Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

Deng, N., Hoyte, A., Mansour, Y. E., Mohamed, M. S., Fuchs, J. R., Engelman, A. N., Kvaratskhelia, M., & Levy, R. (2016) · Protein Science

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 36

A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

Shkriabai, N., Dharmarajan, V., Slaughter, A., Kessl, J. J., Larue, R. C., Feng, L., Fuchs, J. R., Griffin, P. R., & Kvaratskhelia, M. (2014) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 30

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

Hoyte, A. C., Jamin, A. V., Koneru, P. C., Kobe, M. J., Larue, R. C., Fuchs, J. R., Engelman, A. N., & Kvaratskhelia, M. (2017) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 30

The FACT Complex Promotes Avian Leukosis Virus DNA Integration

Winans, S., Larue, R. C., Abraham, C. M., Shkriabai, N., Skopp, A., Winkler, D., Kvaratskhelia, M., & Beemon, K. L. (2017) · Journal of Virology

Virus-based gene therapy researchHIV Research and Treatment

Cited by 26

A new structural insight into XPA–DNA interactions

Hilton, B., Shkriabai, N., Musich, P. R., Kvaratskhelia, M., Shell, S., & Zou, Y. (2014) · Bioscience Reports

DNA Repair MechanismsProtein Structure and Dynamics

Cited by 22