Partridge, James R.

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Metcalf, B., Chuang, C., Dufu, K., Patel, M. P., Silva-Garcia, A., Johnson, C., Lu, Q., Partridge, J. R., Patskovska, L., Patskovsky, Y., et al. (2017) · ACS Medicinal Chemistry Letters

Hemoglobinopathies and Related DisordersHemoglobin structure and function

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Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease

Kerrigan, J. R., Thomsen, N. M., Cernijenko, A., Kochanek, S. E., Dewhurst, J., O’Brien, G., Ware, N. F., Sanchez, C. C., Manning, J. R., Ma, X., et al. (2024) · Journal of Medicinal Chemistry

Hemoglobinopathies and Related DisordersProtein Degradation and Inhibitors

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