Ladiges, Warren

Extension of murine life span by overexpression of catalase targeted to mitochondria

Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 1,724

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,032

An aged immune system drives senescence and ageing of solid organs

Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 972

Mitochondrial point mutations do not limit the natural lifespan of mice

Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 404

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

Ramos, F. J., Chen, S. C., Garelick, M. G., Dai, D.-F., Liao, C.-Y., Schreiber, K. H., MacKay, V. L., An, E. H., Strong, R., Ladiges, W. C., et al. (2012) · Science Translational Medicine

Nuclear Structure and FunctionMuscle Physiology and Disorders

Cited by 349

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance

Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 319

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Lifespan extension in genetically modified mice

Ladiges, W., Van Remmen, H., Strong, R., Ikeno, Y., Treuting, P., Rabinovitch, P., & Richardson, A. (2009) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 101

Measures of Healthspan as Indices of Aging in Mice—A Recommendation

Richardson, A., Fischer, K. E., Speakman, J. R., de Cabo, R., Mitchell, S. J., Peterson, C. A., Rabinovitch, P., Chiao, Y. A., Taffet, G., Miller, R. A., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 81

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M., & Robbins, P. D. (2020) · GeroScience

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 70

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Lee, H.-Y., Lee, J. S., Alves, T., Ladiges, W., Rabinovitch, P. S., Jurczak, M. J., Choi, C. S., Shulman, G. I., & Samuel, V. T. (2017) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 66

Molecular pathology endpoints useful for aging studies

Niedernhofer, L. J., Kirkland, J. L., & Ladiges, W. (2017) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

Tissue specific expression of PKR protein kinase in aging B6D2F1 mice

Ladiges, W., Morton, J., Blakely, C., & Gale, M. (2000) · Mechanisms of Ageing and Development

Genetics, Aging, and Longevity in Model OrganismsRNA and protein synthesis mechanisms

Cited by 34

Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei

Schriner, S. E., Ogburn, C. E., Smith, A. C., Newcomb, T. G., Ladiges, W. C., Dollé, M. E. T., Vijg, J., Fukuchi, K.-I., & Martin, G. M. (2000) · Free Radical Biology and Medicine

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 34

The potential of GHK as an anti-aging peptide

Department of Comparative Medicine, S. O. M., Dou, Y., Lee, A., Zhu, L., Morton, J., & Ladiges, W. (2020) · Aging Pathobiology and Therapeutics

Wound Healing and TreatmentsBiochemical effects in animals

Cited by 33

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

Jiang, Z., Wang, J., Imai, D., Snider, T., Klug, J., Mangalindan, R., Morton, J., Zhu, L., Salmon, A. B., Wezeman, J., et al. (2022) · Scientific Reports

Genetics, Aging, and Longevity in Model OrganismsAntioxidants, Aging, Portulaca oleracea

Cited by 21

Sleep-deprived cognitive impairment in aging mice is alleviated by rapamycin

Mukherjee, K., Lee, A. J., Zhu, L., Darvas, M., & Ladiges, W. (2019) · Aging Pathobiology and Therapeutics

Sleep and Wakefulness ResearchSleep and Work-Related Fatigue

Cited by 10

A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple aging pathways

Jiang, Z., He, Q., Wezeman, J., Darvas, M., & Ladiges, W. (2024) · GeroScience

Genetics, Aging, and Longevity in Model OrganismsAntioxidants, Aging, Portulaca oleracea

Cited by 10

The rationale for testing drug combinations in aging intervention studies

Sharma, K., Wang, J., Jiang, Z., Klug, J., Darvas, M., M. Imai, D., Snider, T., Niedernhofer, L., & Ladiges, W. (2019) · Aging Pathobiology and Therapeutics

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 4

A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer’s disease in aging mice

Wezeman, J., Darvas, M., Postupna, N., Klug, J., Mangalindan, R. S., Keely, A., Nguyen, K., Johnson, C., Rosenfeld, M., & Ladiges, W. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Alzheimer's disease research and treatmentsGenetics, Aging, and Longevity in Model Organisms

Cited by 3