Sarafianos, Stefan G.

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

Gres, A. T., Kirby, K. A., KewalRamani, V. N., Tanner, J. J., Pornillos, O., & Sarafianos, S. G. (2015) · Science

HIV Research and TreatmentEnzyme Structure and Function

Cited by 248

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

Achuthan, V., Perreira, J. M., Sowd, G. A., Puray-Chavez, M., McDougall, W. M., Paulucci-Holthauzen, A., Wu, X., Fadel, H. J., Poeschla, E. M., Multani, A. S., et al. (2018) · Cell Host & Microbe

HIV Research and TreatmentVirus-based gene therapy research

Cited by 205

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Francis, A. C., Marin, M., Singh, P. K., Achuthan, V., Prellberg, M. J., Palermino-Rowland, K., Lan, S., Tedbury, P. R., Sarafianos, S. G., Engelman, A. N., et al. (2020) · Nature Communications

HIV Research and TreatmentVirus-based gene therapy research

Cited by 159

Avoiding drug resistance in HIV reverse transcriptase

Cilento, M. E., Kirby, K. A., & Sarafianos, S. G. (2021) · Chemical Reviews

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 106

Design, synthesis, and biological evaluations of hydroxypyridonecarboxylic acids as inhibitors of HIV reverse transcriptase associated RNase H

Kankanala, J., Kirby, K. A., Liu, F., Miller, L., Nagy, E., Wilson, D. J., Parniak, M. A., Sarafianos, S. G., & Wang, Z. (2016) · Journal of Medicinal Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 66

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity

Ilina, T., LaBarge, K., Sarafianos, S. G., Ishima, R., & Parniak, M. A. (2012) · Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 54

Cutting into the substrate dominance: pharmacophore and structure-based approaches toward inhibiting human immunodeficiency virus reverse transcriptase-associated ribonuclease H

Wang, L., Sarafianos, S. G., & Wang, Z. (2020) · Accounts of Chemical Research

HIV/AIDS drug development and treatmentComputational Drug Discovery Methods

Cited by 43

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

Wang, L., Tang, J., Huber, A. D., Casey, M. C., Kirby, K. A., Wilson, D. J., Kankanala, J., Xie, J., Parniak, M. A., Sarafianos, S. G., et al. (2018) · European Journal of Medicinal Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 36