6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids

Jorgensen, W. L., Maxwell, D. S., & Tirado-Rives, J. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9621760 · Cited by 14,078 · see citing works

Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds

Miyaura, N., & Suzuki, A. (1995) · Chemical Reviews · doi:10.1021/cr00039a007 · Cited by 12,878 · see citing works

Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

Friesner, R. A., Murphy, R. B., Repasky, M. P., Frye, L. L., Greenwood, J. R., Halgren, T. A., Sanschagrin, P. C., & Mainz, D. T. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051256o · Cited by 6,964 · see citing works

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

Sastry, G. M., Adzhigirey, M., Day, T., Annabhimoju, R., & Sherman, W. (2013) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-013-9644-8 · Cited by 6,130 · see citing works

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Sarafianos, S. G., Marchand, B., Das, K., Himmel, D. M., Parniak, M. A., Hughes, S. H., & Arnold, E. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.10.071 · Cited by 539 · see citing works

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

de Béthune, M. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.09.008 · Cited by 406 · see citing works

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

Cihlář, T., & Ray, A. S. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.09.014 · Cited by 372 · see citing works

Current status and prospects of HIV treatment

Cihlář, T., & Fordyce, M. W. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.03.004 · Cited by 336 · see citing works

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

Hare, S., Smith, S. J., Métifiot, M., Jaxa-Chamiec, A., Pommier, Y., Hughes, S. H., & Cherepanov, P. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.073189 · Cited by 264 · see citing works

Strand transfer inhibitors of HIV-1 integrase: bringing IN a new era of antiretroviral therapy.

Mccoll, D., & Chen, X.-W. (2010) · Antiviral Research · doi:10.1016/j.antiviral.2009.11.004 · Cited by 187 · see citing works

Retroviral integrase superfamily: the structural perspective

Nowotny, M. (2009) · The EMBO Reports · doi:10.1038/embor.2008.256 · Cited by 183 · see citing works

Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid

Shaw-Reid, C. A., Munshi, V., Graham, P., Wolfe, A. L., Witmer, M. V., Danzeisen, R. C., Olsen, D. B., Carroll, S. S., Embrey, M. W., Wai, J. S. M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200621200 · Cited by 156 · see citing works

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

Klumpp, K. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg881 · Cited by 151 · see citing works

Mutations within the RNase H Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Abolish Virus Infectivity

Tisdale, M., Schulze, T., Larder, B. A., & Moelling, K. (1991) · Journal of General Virology · doi:10.1099/0022-1317-72-1-59 · Cited by 148 · see citing works

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

Vernekar, S. K. V., Liu, Z., Nagy, E., Miller, L. G., Kirby, K. A., Wilson, D. J., Kankanala, J., Sarafianos, S. G., Parniak, M. A., & Wang, Z. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501132s · Cited by 143 · see citing works

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

Himmel, D. M., Maegley, K. A., Pauly, T., Bauman, J. D., Das, K., Dharia, C., Clark, A. D., Ryan, K., Hickey, M. J., Love, R. A., et al. (2009) · Structure · doi:10.1016/j.str.2009.09.016 · Cited by 142 · see citing works

A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity

Parniak, M. A., Min, K., Budihas, S. R., Grice, S. F. J. L., & Beutler, J. A. (2003) · Analytical Biochemistry · doi:10.1016/j.ab.2003.06.001 · Cited by 127 · see citing works

Design of MKC-442 (Emivirine) Analogues with Improved Activity Against Drug-Resistant HIV Mutants

Hopkins, A. L., Ren, J., Tanaka, H., Baba, M., Okamato, M., Stuart, D. I., & STAMMERS, D. K. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990192c · Cited by 116 · see citing works

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186

Hopkins, A. L., Ren, J., Tanaka, H., Baba, M., Okamato, M., Stuart, D. I., & STAMMERS, D. K. (1999) · Worldwide Protein Data Bank · doi:10.2210/pdb1c1b/pdb · Cited by 105 · see citing works

RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information

Kirschberg, T. A., Balakrishnan, M., Squires, N. H., Barnes, T. L., Brendza, K. M., Chen, X., Eisenberg, E. J., Jin, W., Kutty, N., Leavitt, S. A., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900597q · Cited by 96 · see citing works

Rationally Designed Dual Inhibitors of HIV Reverse Transcriptase and Integrase

Wang, Z., Bennett, E. M., Wilson, D. J., Salomon, C. E., & Vince, R. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070512p · Cited by 90 · see citing works

HIV-1 ribonuclease H: structure, catalytic mechanism and inhibitors

Beilhartz, G. L., & Götte, M. (2010) · Viruses · doi:10.3390/v2040900 · Cited by 88 · see citing works

Clicking 3′-Azidothymidine into Novel Potent Inhibitors of Human Immunodeficiency Virus

Sirivolu, V. R., Vernekar, S. K. V., Ilina, T. V., Myshakina, N. S., Parniak, M. A., & Wang, Z. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401232v · Cited by 85 · see citing works

Biochemical Mechanism of HIV-1 Resistance to Rilpivirine

Singh, K., Marchand, B., Rai, D. K., Sharma, B., Michailidis, E., Ryan, E. M., Matzek, K. B., Leslie, M. D., Hagedorn, A. N., Li, Z., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.398180 · Cited by 68 · see citing works

Single-Step Purification of Recombinant Wild-Type and Mutant HIV-1 Reverse Transcriptase

Fletcher, R. S., Holleschak, G., Nagy, E., Arion, D., Borkow, G., Gu, Z., Wainberg, M. A., & Parniak, M. A. (1996) · Protein Expression and Purification · doi:10.1006/prep.1996.0004 · Cited by 66 · see citing works

Design, synthesis, and biological evaluations of hydroxypyridonecarboxylic acids as inhibitors of HIV reverse transcriptase associated RNase H

Kankanala, J., Kirby, K. A., Liu, F., Miller, L., Nagy, E., Wilson, D. J., Parniak, M. A., Sarafianos, S. G., & Wang, Z. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00465 · Cited by 66 · see citing works

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

Williams, P. D., Staas, D. D., Venkatraman, S., Loughran, H. M., Ruzek, R. D., Booth, T. M., Lyle, T. A., Wai, J. S. M., Vacca, J. P., Feuston, B. P., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.08.135 · Cited by 59 · see citing works

Virion Instability of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Mutated in the Protease Cleavage Site between RT p51 and the RT RNase H Domain

Abram, M. E., & Parniak, M. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.18.11952-11961.2005 · Cited by 53 · see citing works

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

Tang, J. Y., Liu, F., Nagy, E., Miller, L. G., Kirby, K. A., Wilson, D. J., Wu, B., Sarafianos, S. G., Parniak, M. A., & Wang, Z. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01879 · Cited by 49 · see citing works

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

Kankanala, J., Kirby, K. A., Huber, A. D., Casey, M. C., Wilson, D. J., Sarafianos, S. G., & Wang, Z. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.054 · Cited by 45 · see citing works

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

Vernekar, S. K. V., Tang, J. Y., Wu, B., Huber, A. D., Casey, M. C., Myshakina, N. S., Wilson, D. J., Kankanala, J., Kirby, K. A., Parniak, M. A., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00440 · Cited by 44 · see citing works

Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs

Himmel, D. M., Myshakina, N. S., Ilina, T. V., Ry, A. V., Ho, W. C., Parniak, M. A., & Arnold, E. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.05.006 · Cited by 41 · see citing works

Targeting HIV-1 integrase with strand transfer inhibitors

Li, Y., Xuan, S., Feng, Y., & Yan, A. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.12.001 · Cited by 39 · see citing works

Recent progress in the research of small molecule HIV-1 RNase H inhibitors

Cao, L., Song, W., Clercq, E., Zhan, P., & Liu, X. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140120121158 · Cited by 34 · see citing works

Impact of baseline HIV‐1 RNA levels on initial highly active antiretroviral therapy outcome: a meta‐analysis of 12,370 patients in 21 clinical trials*

Stephan, C., Hill, A., Sawyer, W., van Delft, Y., & Moecklinghoff, C. (2012) · HIV Medicine · doi:10.1111/hiv.12004 · Cited by 28 · see citing works

Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation

Beilhartz, G. L., Ngure, M., Johns, B. A., Deanda, F., Gerondelis, P., & Götte, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.569707 · Cited by 28 · see citing works

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase

Tang, J. Y., Kirby, K. A., Huber, A. D., Casey, M. C., Ji, J., Wilson, D. J., Sarafianos, S. G., & Wang, Z. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.01.041 · Cited by 27 · see citing works

Synthesis and properties of 1‐Benzothiopyrano[2,3‐d]‐pyrimidine‐2,4‐(3H)diones (10‐thia‐5‐deazaflavins)

Yoneda, F., Tsukuda, K., Kawazoe, M., Sone, A., & Koshiro, A. (1981) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.5570180711 · Cited by 16 · see citing works

Polyoxometalate catalysts for the synthesis of N-heterocycles

Hu, Q.-L., Li, K., Chen, X., Liu, Y., & Yang, G. (2023) · Polyoxometalates · doi:10.26599/pom.2023.9140048 · Cited by 79 · see citing works

Strategies to overcome HIV drug resistance-current and future perspectives

Temereanca, A., & Ruță, S. M. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1133407 · Cited by 67 · see citing works

Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus

Tramontano, E., Corona, A., & Menéndez‐Arias, L. (2019) · Antiviral Research · doi:10.1016/j.antiviral.2019.104613 · Cited by 57 · see citing works

Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters

He, Z., Zhao, T., Gong, Y., Zhang, X., Ma, L., & Liu, H. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112458 · Cited by 55 · see citing works

Cutting into the substrate dominance: pharmacophore and structure-based approaches toward inhibiting human immunodeficiency virus reverse transcriptase-associated ribonuclease H

Wang, L., Sarafianos, S. G., & Wang, Z. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00450 · Cited by 43 · see citing works

In silico study of 3-hydroxypyrimidine-2,4-diones as inhibitors of HIV RT-associated RNase H using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore models

Gao, Y., Chen, Y.-M., Tian, Y., Zhao, Y., Wu, F., Luo, X., Ju, X.-L., & Liu, G. (2019) · New Journal of Chemistry · doi:10.1039/c9nj03353j · Cited by 29 · see citing works

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

Escobar, A. M., Blustein, G., Luque, R., & Romanelli, G. P. (2021) · Catalysts · doi:10.3390/catal11020291 · Cited by 29 · see citing works

Strategies and Methods for the Synthesis of 2‐Pyrazolines: Recent Developments (2012–2022)

Matiadis, D. (2023) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.202300373 · Cited by 29 · see citing works

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker

Tang, J. Y., Do, H. T., Huber, A. D., Casey, M. C., Kirby, K. A., Wilson, D. J., Kankanala, J., Parniak, M. A., Sarafianos, S. G., & Wang, Z. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.081 · Cited by 27 · see citing works

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

Corona, A., Ballana, E., Distinto, S., Rogolino, D., Vecchio, C. D., Carcelli, M., Badía, R., Riveira‐Muñoz, E., Esposito, F., Parolin, C., et al. (2020) · Viruses · doi:10.3390/v12070729 · Cited by 22 · see citing works

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV ‐1 RN ase H inhibitors

Gao, P., Wang, X., Sun, L., Cheng, X., Poongavanam, V., Kongsted, J., Álvarez, M., Luczkowiak, J., Pannecouque, C. C., Clercq, E. D., et al. (2018) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13455 · Cited by 20 · see citing works

Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors

Zhang, L., Wei, F., Zhang, J., Liu, C., López‐Carrobles, N., Liu, X., Menéndez‐Arias, L., & Zhan, P. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114760 · Cited by 19 · see citing works

2-(Arylamino)-6-(trifluoromethyl)nicotinic acid derivatives: new HIV-1 RT dual inhibitors active on viral replication

Corona, A., Onnis, V., Del Vecchio, C., Esposito, F., Cheng, Y.-C., & Tramontano, E. (2020) · Molecules · doi:10.3390/molecules25061338 · Cited by 19 · see citing works

Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H

Kang, J.-X., Zhao, G.-K., Yang, X., Huang, M.-X., Hui, W., Zeng, R., & Ouyang, Q. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115196 · Cited by 18 · see citing works

Retroviral RNase H: structure, mechanism, and inhibition

(2021) · The Enzymes · doi:10.1016/bs.enz.2021.07.007 · Cited by 13 · see citing works

Targeting Ribonucleases with Small Molecules and Bifunctional Molecules

Borgelt, L., & Wu, P. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00191 · Cited by 13 · see citing works

Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy

Zhu, X.-D., Corona, A., Maloccu, S., Tramontano, E., Wang, S., Pannecouque, C. C., Clercq, E. D., Meng, G., & Chen, F. (2024) · Molecules · doi:10.3390/molecules29092120 · Cited by 12 · see citing works

Recent developments of pyrimidine appended HIV-1 non-nucleoside reverse transcriptase inhibitors

Rahman, S. M. A., Singh, G., Khan, S., Balasubramaniam, A. K., & Monga, V. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108273 · Cited by 11 · see citing works

Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex

Wang, L., Edwards, T. C., Sahani, R. L., Xie, J., Aihara, H., Geraghty, R. J., & Wang, Z. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113640 · Cited by 9 · see citing works

4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

He, T., Edwards, T. C., Xie, J., Aihara, H., Geraghty, R. J., & Wang, Z. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00203 · Cited by 8 · see citing works

Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors

Zhang, L., Wei, F., Borrego, D., Zhao, F., del Río, J. M., Frutos-Beltrán, E., Zhang, J., Xu, S., López‐Carrobles, N., Gao, S., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114563 · Cited by 8 · see citing works

Repurposing N-hydroxy thienopyrimidine-2,4-diones (HtPD) as inhibitors of human cytomegalovirus pUL89 endonuclease: Synthesis and biological characterization

He, T., Edwards, T. C., Majima, R., Jung, E., Kankanala, J., Xie, J., Geraghty, R. J., & Wang, Z. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106198 · Cited by 7 · see citing works

Pyrimidine-Piperazine Hybrids; Recent Synthesis and Biological Activities

Al‐Ghorbani, M., Gouda, M. A., Baashen, M., & Lakshmi Ranganatha, V. (2021) · Polycyclic aromatic compounds · doi:10.1080/10406638.2021.1998144 · Cited by 6 · see citing works

Current scenario on non-nucleoside reverse transcriptase inhibitors (2018-present)

Deng, C., Yan, H., Wang, J., Liu, K., Liu, B., & Shi, Y.-M. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.104378 · Cited by 5 · see citing works

8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

Jung, E., Majima, R., Edwards, T. C., Soto-Acosta, R., Geraghty, R. J., & Wang, Z. (2022) · ChemMedChem · doi:10.1002/cmdc.202200334 · Cited by 5 · see citing works

Uracil derivatives as non-nucleoside inhibitors targeting HIV-1 reverse transcriptase

Chen, J. P., Yang, G., Tian, L., Zhu, Y., Zhang, S., & Gu, S. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118797 · Cited by 4 · see citing works

Uracil derivatives as non-nucleoside inhibitors of viral infections

Khandazhinskaya, A. L., Matyugina, E. S., & Novikov, M. S. (2021) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2021.08.001 · Cited by 2 · see citing works

Synthesis and Antiproliferative Activity of 2,4,5,6-Tetrasubstituted Pyrimidine Derivatives Containing Anisole

Gao, C., Si, X., Chi, L., Wang, H., Dai, H., Liu, L., Wang, Z., Yang, Z., Wang, T., Zhou, Y., et al. (2022) · Chinese Journal of Organic Chemistry · doi:10.6023/cjoc202201048 · Cited by 2 · see citing works

Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors

Zhang, Y., Wang, R., Bu, Y., Corona, A., Dettori, L., Tramontano, E., Pannecouque, C. C., Clercq, E. D., Wang, S., Meng, G., et al. (2025) · Molecules · doi:10.3390/molecules30091868 · Cited by 1 · see citing works

Chemical synthesis, bioinformatics and antiproliferative studies of novel pyrimidin-4-yl-1H-pyrazole derivatives in chronic myeloid cancer cells

Rajasheker, K. V., Pallavi, M. S., Arun, P. C., Stupin, V. A., Iqbal, M., Roma‐Rodrigues, C., Baptista, P. V., Fernandes, A. R., Silina, E., & Kollur, S. P. (2026) · Scientific Reports · doi:10.1038/s41598-025-26292-7 · Cited by 1 · see citing works

Synthesis and in vitro antitumor activity evaluation of novel 5-cyano-6-phenyl-2,4-disubstituted-pyrimidine derivatives

Si, X., Gao, C., Chi, L., Wang, H., Zhang, Y., Dai, H., Liu, L., Wang, Z., Zheng, J., Ke, Y., et al. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02950-7 · Cited by 1 · see citing works

The sodium 5-butyl-1,2-diphenyl-6-oxo-1,6-dihydropyrimidine-4-olate quantitative content determination in a standard sample

Kuvaeva, E. V., Kolesnik, D. A., Levshukova, P. O., Terninko, I. I., Yakovlev, I. P., & Fedorova, E. V. (2021) · Drug development & registration · doi:10.33380/2305-2066-2021-10-4(1)-115-121

Synthesis and Antitumor Activity Evaluation in Vitro of Novel 5-cyano-6-phenyl-2,4-Disubstituted Pyrimidine DerivativesPreprint

Si, X., Gao, C., Chi, L., Wang, H., Zhang, Y., Dai, H., Liu, L., Wang, Z., Zheng, J., Ke, Y., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1689627/v1

Integrated Computational Exploration of Pyrimidine-2,4-dione Derivatives as Dual HIV-1 RT/RNase H Inhibitor

Masaoudy, Y. E., Rehman, H. M., Alaqarbeh, M., Maghat, H., Lakhlifi, T., & Bouachrıne, M. (2026) · Drug development & registration · doi:10.33380/2305-2066-2026-15-2-2225

BindingDB Entry 50009211: Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.

BindingDB (2021) · UC San Diego · doi:10.7270/q2fj2m7h

BindingDB Entry 50017766: 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.

BindingDB (2023) · UC San Diego · doi:10.7270/q2x352jx

BindingDB Entry 50016126: Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors.

BindingDB (2023) · UC San Diego · doi:10.7270/q2q2448k

BindingDB Entry 50019491: Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors.

BindingDB (2024) · UC San Diego · doi:10.7270/q2mk6j73

BindingDB Entry 50014016: Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex.

BindingDB (2022) · UC San Diego · doi:10.7270/q2028wbk

BindingDB Entry 50018741: Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters.

BindingDB (2024) · UC San Diego · doi:10.7270/q2r215mn

BindingDB Entry 50021230: Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H.

BindingDB (2025) · UC San Diego · doi:10.7270/q2mw2nq6

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

Wang, L., Tang, J. Y., Huber, A. D., Casey, M. C., Kirby, K. A., Wilson, D. J., Kankanala, J., Parniak, M. A., Sarafianos, S. G., & Wang, Z. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.07.035 · Cited by 32 · see citing works

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

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