Wang, Shaomeng

Targeting the MDM2-p53 protein–protein interaction for new cancer therapeutics

Wang, S., Zhao, Y., Bernard, D., Aguilar, A., & Kumar, S. (2012) · Topics in Medicinal Chemistry

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 72

MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function

Azmi, A. S., Aboukameel, A., Banerjee, S., Wang, Z., Mohammad, M., Wu, J., Wang, S., Yang, D., Philip, P. A., Sarkar, F. H., et al. (2010) · European Journal of Cancer

Cancer-related Molecular PathwaysPancreatic and Hepatic Oncology Research

Cited by 67

Hydrophobic Binding Hot Spots of Bcl-xL Protein−Protein Interfaces by Cosolvent Molecular Dynamics Simulation

Yang, C.-Y., & Wang, S. (2011) · ACS Medicinal Chemistry Letters

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 57

p53-mediated heterochromatin reorganization regulates its cell fate decisions.

Mungamuri, S. K., Benson, E. K., Wang, S., Gu, W., Lee, S. W., & Aaronson, S. A. (2012) · Nature Structural & Molecular Biology

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 53

Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo

Hoffman-Luca, C. G., Ziazadeh, D., McEachern, D., Zhao, Y., Sun, W., Debussche, L., & Wang, S. (2015) · Clinical Cancer Research

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 52

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein–Protein Interaction

Aguilar, A., Zheng, K., Xu, T., Xu, S., Huang, L., Fernandez-Salas, E., Liu, L., Bernard, D., Harvey, K. P., Foster, C., et al. (2019) · Journal of Medicinal Chemistry

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 39

Therapeutic inhibition of the MDM2-p53 interaction prevents recurrence of adenoid cystic carcinomas

Nör, F., Warner, K. A., Zhang, Z., Acasigua, G. A., Pearson, A. T., Kerk, S. A., Helman, J. I., Sant'Ana Filho, M., Wang, S., & Nör, J. E. (2017) · Clinical Cancer Research

Cancer-related Molecular PathwaysSalivary Gland Tumors Diagnosis and Treatment

Cited by 37

Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors

Gomez, C., Bai, L., Zhang, J., Nikolovska-Coleska, Z., Chen, J., Yi, H., & Wang, S. (2009) · Bioorganic & Medicinal Chemistry Letters

Cytokine Signaling Pathways and InteractionsHeterocyclic Compound Synthesis and Bioactivity

Cited by 26