Lambris, John D.

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology

Complement system in diseasesBiomarkers in Disease Mechanisms

Cited by 3,654

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell

Complement system in diseasesNeuroscience and Neuropharmacology Research

Cited by 3,313

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe

Oral microbiology and periodontitis researchGut microbiota and health

Cited by 1,154

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Skendros, P., Mitsios, A., Chrysanthopoulou, A., Mastellos, D. C., Metallidis, S., Rafailidis, P., Ntinopoulou, M., Sertaridou, E., Tsironidou, V., Tsigalou, C., et al. (2020) · Journal of Clinical Investigation

Neutrophil, Myeloperoxidase and Oxidative MechanismsComplement system in diseases

Cited by 786

Drusen complement components C3a and C5a promote choroidal neovascularization

Nozaki, M., Raisler, B. J., Sakurai, E., Sarma, J. V., Barnum, S. R., Lambris, J. D., Chen, Y., Zhang, K., Ambati, B. K., Baffi, J. Z., et al. (2006) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 650

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

Wyss-Coray, T., Yan, F., Lin, A. H.-T., Lambris, J. D., Alexander, J. J., Quigg, R. J., & Masliah, E. (2002) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 446

The proinflammatory mediators C3a and C5a are essential for liver regeneration

Strey, C. W., Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L. A., Greenbaum, L. E., & Lambris, J. D. (2003) · The Journal of Experimental Medicine

Liver physiology and pathologyComplement system in diseases

Cited by 436

The role of complement in biomaterial-induced inflammation

Nilsson, B., Ekdahl, K. N., Mollnes, T. E., & Lambris, J. D. (2007) · Molecular Immunology

Complement system in diseasesBiomarkers in Disease Mechanisms

Cited by 431

The renaissance of complement therapeutics

Ricklin, D., Mastellos, D. C., Reis, E. S., & Lambris, J. D. (2018) · Nature Reviews Nephrology

Complement system in diseasesCoagulation, Bradykinin, Polyphosphates, and Angioedema

Cited by 379

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

Mastellos, D. C., Pires da Silva, B. G. P., Fonseca, B. A. L., Fonseca, N. P., Auxiliadora-Martins, M., Mastaglio, S., Ruggeri, A., Sironi, M., Radermacher, P., Chrysanthopoulou, A., et al. (2020) · Clinical Immunology

Complement system in diseasesCOVID-19 Clinical Research Studies

Cited by 255

Complement modulates the cutaneous microbiome and inflammatory milieu

Chehoud, C., Rafail, S., Tyldsley, A. S., Seykora, J. T., Lambris, J. D., & Grice, E. A. (2013) · Proceedings of the National Academy of Sciences

Dermatology and Skin DiseasesComplement system in diseases

Cited by 184

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

Langer, H. F., Chung, K.-J., Orlova, V. V., Choi, E. Y., Kaul, S., Kruhlak, M. J., Alatsatianos, M., DeAngelis, R. A., Roche, P. A., Magotti, P., et al. (2010) · Blood

Complement system in diseasesAngiogenesis and VEGF in Cancer

Cited by 176

C5a and TNF-α Up-Regulate the Expression of Tissue Factor in Intra-Alveolar Neutrophils of Patients with the Acute Respiratory Distress Syndrome

Kambas, K., Markiewski, M. M., Pneumatikos, I. A., Rafail, S. S., Theodorou, V., Konstantonis, D., Kourtzelis, I., Doumas, M. N., Magotti, P., DeAngelis, R. A., et al. (2008) · The Journal of Immunology

Blood Coagulation and Thrombosis MechanismsRespiratory Support and Mechanisms

Cited by 127

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

Hadziahmetovic, M., Dentchev, T., Song, Y., Haddad, N., He, X., Hahn, P., Pratico, D., Wen, R., Harris, Z. L., Lambris, J. D., et al. (2008) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 121

The challenges and promise of complement therapeutics for ocular diseases

Park, D. H., Connor, K. M., & Lambris, J. D. (2019) · Frontiers in Immunology

Complement system in diseasesRetinal Diseases and Treatments

Cited by 108

Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration

Haynes, T., Luz-Madrigal, A., Reis, E. S., Echeverri Ruiz, N. P., Grajales-Esquivel, E., Tzekou, A., Tsonis, P. A., Lambris, J. D., & Del Rio-Tsonis, K. (2013) · Nature Communications

Retinal Development and DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 87

Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H

Alsenz, J., Schulz, T. F., Lambris, J. D., Sim, R. B., & Dierich, M. P. (1985) · Biochemical Journal

Complement system in diseasesCoagulation, Bradykinin, Polyphosphates, and Angioedema

Cited by 87

Complement deficiency promotes cutaneous wound healing in mice

Rafail, S., Kourtzelis, I., Foukas, P. G., Markiewski, M. M., DeAngelis, R. A., Guariento, M., Ricklin, D., Grice, E. A., & Lambris, J. D. (2015) · The Journal of Immunology

Wound Healing and TreatmentsComplement system in diseases

Cited by 72

Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

Cerniauskas, E., Kurzawa-Akanbi, M., Xie, L., Hallam, D., Moya-Molina, M., White, K., Steel, D., Doherty, M., Whitfield, P., Al-Aama, J., et al. (2020) · Stem Cells Translational Medicine

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 58

Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

Mangsbo, S. M., Sanchez, J., Anger, K., Lambris, J. D., Ekdahl, K. N., Loskog, A. S., Nilsson, B., & Tötterman, T. H. (2009) · The Journal of Immunology

Complement system in diseasesImmune Response and Inflammation

Cited by 42

The alternative complement pathway regulates pathological angiogenesis in the retina

Sweigard, J. H., Yanai, R., Gaissert, P., Saint‐Geniez, M., Kataoka, K., Thanos, A., Stahl, G. L., Lambris, J. D., & Connor, K. M. (2014) · The FASEB Journal

Retinal Diseases and TreatmentsRetinopathy of Prematurity Studies

Cited by 38

Cp40-mediated complement C3 inhibition dampens inflammasome activation and inflammatory mediators storm induced by Bitis arietans venom

Fernandes, D. C., Silva-de-França, F., Pohl, P. C., Eto, S. F., Sardinha, L. R., Lambris, J. D., & Tambourgi, D. V. (2025) · International Immunopharmacology

Venomous Animal Envenomation and StudiesComplement system in diseases

Cited by 3