Shelton, John M.

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

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A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

Anderson, D. M., Anderson, K. M., Chang, C.-L., Makarewich, C. A., Nelson, B. R., McAnally, J. R., Kasaragod, P., Shelton, J. M., Liou, J., Bassel-Duby, R., et al. (2015) · Cell

Muscle Physiology and DisordersRNA Research and Splicing

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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences

Drug Transport and Resistance MechanismsGut microbiota and health

Cited by 1,164

Hippo pathway effector Yap promotes cardiac regeneration

Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences

Congenital heart defects researchHippo pathway signaling and YAP/TAZ

Cited by 895

Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA

Long, C., McAnally, J. R., Shelton, J. M., Mireault, A. A., Bassel-Duby, R., & Olson, E. N. (2014) · Science

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 720

Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism

Adipose Tissue and MetabolismMitochondrial Function and Pathology

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Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy

Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., Harron, R., Stathopoulou, T.-R., Massey, C., Shelton, J. M., et al. (2018) · Science

Muscle Physiology and DisordersCRISPR and Genetic Engineering

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Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

Li, K., Li, Y., Shelton, J. M., Richardson, J. A., Spencer, E., Chen, Z. J., Wang, X., & Williams, R. S. (2000) · Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 509

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice.

Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.-J., Marck, B. T., Matsumoto, A. M., Shelton, J. M., Richardson, J. A., et al. (2003) · Nature Genetics

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 496

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

Gotthardt, M., Trommsdorff, M., Nevitt, M. F., Shelton, J., Richardson, J. A., Stockinger, W., Nimpf, J., & Herz, J. (2000) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismReceptor Mechanisms and Signaling

Cited by 450

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., & Burgess, S. C. (2012) · Journal of Lipid Research

Mitochondrial Function and PathologyLiver Disease Diagnosis and Treatment

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Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy

Amoasii, L., Long, C., Li, H., Mireault, A. A., Shelton, J. M., Sanchez-Ortiz, E., McAnally, J. R., Bhattacharyya, S., Schmidt, F., Grimm, D., et al. (2017) · Science Translational Medicine

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 247

Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2

Nakagawa, O., Arnold, M., Nakagawa, M., Hamada, H., Shelton, J. M., Kusano, H., Harris, T. M., Childs, G., Campbell, K. P., Richardson, J. A., et al. (2005) · Genes & Development

Muscle Physiology and DisordersGenomics and Chromatin Dynamics

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The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner

Hwang, S.-H., White, K. A., Somatilaka, B. N., Shelton, J. M., Richardson, J. A., & Mukhopadhyay, S. (2018) · Development

Hedgehog Signaling Pathway StudiesGenetic and Kidney Cyst Diseases

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Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Shimada, I. S., Hwang, S.-H., Somatilaka, B. N., Wang, X., Skowron, P., Kim, J., Kim, M., Shelton, J. M., Rajaram, V., Xuan, Z., et al. (2018) · Cell Reports

Hedgehog Signaling Pathway StudiesGlioma Diagnosis and Treatment

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