Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
Open accessAbstract
The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways that traverse mitochondria are actually increased. The tricarboxylic acid (TCA) cycle is the site of terminal fat oxidation, chief source of electrons for respiration, and a metabolic progenitor of gluconeogenesis. Therefore, we tested whether insulin resistance promotes hepatic TCA cycle flux in mice progressing to insulin resistance and fatty liver on a high-fat diet (HFD) for 32 weeks using standard biomolecular and in vivo (2)H/(13)C tracer methods. Relative mitochondrial content increased, but respiratory efficiency declined by 32 weeks of HFD. Fasting ketogenesis became unresponsive to feeding or insulin clamp, indicating blunted but constitutively active mitochondrial β-oxidation. Impaired insulin signaling was marked by elevated in vivo gluconeogenesis and anaplerotic and oxidative TCA cycle flux. The induction of TCA cycle function corresponded to the development of mitochondrial respiratory dysfunction, hepatic oxidative stress, and inflammation. Thus, the hepatic TCA cycle appears to enable mitochondrial dysfunction during insulin resistance by increasing electron deposition into an inefficient respiratory chain prone to reactive oxygen species production and by providing mitochondria-derived substrate for elevated gluconeogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In mice fed a high-fat diet for 8 weeks, hepatic insulin resistance and simple steatosis are established before changes in mitochondrial bioenergetics become evident.
“In line with these arguments, both hepatic insulin resistance and simple steatosis were already established in mice fed a high-fat diet for 8 weeks, well before changes in mitochondrial bioenergetics became evident166,167.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [167]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285 · see citing works
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078 · see citing works
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990 · see citing works
Regulation of hepatic fatty acid oxidation and ketone body production
McGarry, J. D., & Foster, D. W. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002143 · Cited by 1,460 · see citing works
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322 · see citing works
Macrophage-mediated inflammation in metabolic disease
Chawla, A., Nguyen, K. D., & Goh, Y. P. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3071 · Cited by 1,314 · see citing works
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts
Frezza, C., Cipolat, S., & Scorrano, L. (2007) · Nature Protocols · doi:10.1038/nprot.2006.478 · Cited by 1,188 · see citing works
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2327 · Cited by 1,177 · see citing works
The key role of anaplerosis and cataplerosis for citric acid cycle function
Owen, O. E., Kalhan, S. C., & Hanson, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200006200 · Cited by 1,172 · see citing works
Disordered lipid metabolism and the pathogenesis of insulin resistance.
Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107 · see citing works
Ceramides in insulin resistance and lipotoxicity
Summers, S. A. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.002 · Cited by 852 · see citing works
Magnusson, I., Rothman, D. L., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115997 · Cited by 757 · see citing works
Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.004 · Cited by 672 · see citing works
Self-citationThe role of mitochondria in insulin resistance and type 2 diabetes mellitus
Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · see citing works
The role of FoxO in the regulation of metabolism
Gross, D. N., van den Heuvel, A. P. J., & Birnbaum, M. J. (2008) · Oncogene · doi:10.1038/onc.2008.25 · Cited by 555 · see citing works
Huang, W., Metlakunta, A., Dedousis, N., Zhang, P., Sipula, I., Dube, J. J., Scott, D. K., & O'Doherty, R. M. (2010) · Diabetes · doi:10.2337/db09-0016 · Cited by 520 · see citing works
Contributions of gluconeogenesis to glucose production in the fasted state
Landau, B. R., Wahren, J., Chandramouli, V, Schumann, W. C., Ekberg, K., & Kalhan, S. C. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118803 · Cited by 487 · see citing works
Alterations in Liver ATP Homeostasis in Human Nonalcoholic Steatohepatitis
Cortez‐Pinto, H., Chatham, J. C., Chacko, V. P., Arnold, C., Rashid, A., & Diehl, A. M. (1999) · JAMA · doi:10.1001/jama.282.17.1659 · Cited by 487 · see citing works
An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450 · see citing works
Pessayre, D., & Fromenty, B. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.03.004 · Cited by 441 · see citing works
Diraison, F., Moulin, P., & Beylot, M. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70061-7 · Cited by 435 · see citing works
FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway
Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.019 · Cited by 431 · see citing works
Self-citationNakamura, S., Takamura, T., Matsuzawa-Nagata, N., Takayama, H., Misu, H., Noda, H., Nabemoto, S., Kurita, S., Ota, T., Ando, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901488200 · Cited by 426 · see citing works
Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.
WILLIAMSON, J. R., Kreisberg, R. A., & Felts, P. W. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.56.1.247 · Cited by 390 · see citing works
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., et al. (2011) · Biochemical Journal · doi:10.1042/bj20100791 · Cited by 382 · see citing works
Gao, D., Nong, S., Huang, X., Lu, Y., Zhao, H., Lin, Y., Man, Y., Wang, S., Yang, J., & Li, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.128694 · Cited by 325 · see citing works
Foxo1 integrates insulin signaling with mitochondrial function in the liver
Cheng, Z., Guo, S., Copps, K., Dong, X., Kollipara, R., Rodgers, J. T., Depinho, R. A., Puigserver, P., & White, M. F. (2009) · Nature Medicine · doi:10.1038/nm.2049 · Cited by 321 · see citing works
Zhang, D., Liu, Z.-X., Choi, C. S., Tian, L., Kibbey, R., Dong, J., Cline, G. W., Wood, P. A., & Shulman, G. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707060104 · Cited by 291 · see citing works
Burgess, S. C., He, T.-T., Yan, Z., Lindner, J., Sherry, A. D., Malloy, C. R., Browning, J. D., & Magnuson, M. A. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.004 · Cited by 276 · see citing works
Self-citationMantena, S. K., Vaughn, D. P., Andringa, K. K., Eccleston, H. B., King, A. L., Abrams, G. A., Doeller, J. E., Kraus, D. W., Darley-Usmar, V. M., & Bailey, S. M. (2009) · Biochemical Journal · doi:10.1042/bj20080868 · Cited by 265 · see citing works
Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis
Cusi, K. J. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.07.009 · Cited by 263 · see citing works
Serviddio, G., Bellanti, F., Tamborra, R., Rollo, T., Capitanio, N., Romano, A. D., Sastre, J., Vendemiale, G., & Altomare, E. (2008) · Gut · doi:10.1136/gut.2007.147496 · Cited by 214 · see citing works
Abnormal Hepatic Energy Homeostasis in Type 2 Diabetes†
Szendroedi, J., Chmelik, M., Schmid, A. I., Nowotny, P., Brehm, A., Krssak, M., Moser, E., & Roden, M. (2009) · Hepatology · doi:10.1002/hep.23093 · Cited by 204 · see citing works
Rate control of the tricarboxylic acid cycle
Krebs, H. A. (1970) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(70)90028-2 · Cited by 196 · see citing works
Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models
Cheng, Z., & White, M. F. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3370 · Cited by 194 · see citing works
Groen, A. K., van Roermund, C. W. T., Vervoorn, R. C., & Tager, J. M. (1986) · Biochemical Journal · doi:10.1042/bj2370379 · Cited by 184 · see citing works
Regulation of the citric acid cycle in mammalian systems
WILLIAMSON, J. R., & Cooper, R. H. (1980) · FEBS Letters · doi:10.1016/0014-5793(80)80572-2 · Cited by 180 · see citing works
Samuel, V. T., Beddow, S. A., Iwasaki, T., Zhang, X., Chu, X., Still, C. D., Gerhard, G. S., & Shulman, G. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812547106 · Cited by 176 · see citing works
Iozzo, P., Bucci, M., Roivainen, A., Någren, K., Järvisalo, M. J., Kišš, J., Guiducci, L., Fielding, B. A., Naum, A. S., Borra, R., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.039 · Cited by 175 · see citing works
Noninvasive tracing of Krebs cycle metabolism in liver.
Magnusson, I., Schumann, W. C., Bartsch, G. E., Chandramouli, V., Kumaran, K., Wahren, J., & Landau, B. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89598-2 · Cited by 152 · see citing works
Chevalier, S., Burgess, S. C., Malloy, C. R., Gougeon, R., Marliss, E. B., & Morais, J. A. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-1117 · Cited by 121 · see citing works
Self-citationBurgess, S. C., Leone, T. C., Wende, A. R., Croce, M. A., Chen, Z., Sherry, A. D., Malloy, C. R., & Finck, B. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600050200 · Cited by 111 · see citing works
Self-citationJin, E. S., Jones, J. G., Merritt, M. E., Burgess, S. C., Malloy, C. R., & Sherry, A. D. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2003.12.036 · Cited by 105 · see citing works
Self-citationAdipose tissue fatty acid metabolism in insulin-resistant men
Bickerton, A. S. T., Roberts, R., Fielding, B. A., Tornqvist, H. E., Blaak, E. E., Wagenmakers, A. J. M., Gilbert, M., Humphreys, S. M., Karpe, F., & Frayn, K. N. (2008) · Diabetologia · doi:10.1007/s00125-008-1040-x · Cited by 100 · see citing works
Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients
Takamura, T., Misu, H., Matsuzawa‐Nagata, N., Sakurai, M., Ota, T., Shimizu, A., Kurita, S., Takeshita, Y., Ando, H., Honda, M., et al. (2008) · Obesity · doi:10.1038/oby.2008.419 · Cited by 96 · see citing works
Jones, J. G., Naidoo, R., Sherry, A. D., Jeffrey, F. M. H., Cottam, G. L., & Malloy, C. R. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00764-3 · Cited by 92 · see citing works
Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet
Sunny, N. E., Satapati, S., Fu, X., He, T., Mehdibeigi, R., Spring-Robinson, C. L., Duarte, J. A. G., Potthoff, M. J., Browning, J. D., & Burgess, S. C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2010 · Cited by 83 · see citing works
Self-citationControl of gluconeogenesis in rat liver cells
Groen, A. K., Vervoorn, R. C., & Tager, J. M. (1983) · Biochemical Society Transactions · doi:10.1042/bst0110088 · Cited by 77 · see citing works
Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis†
Caldwell, S. H., de Freitas, L. A. R., Park, S. H., Moreno, M. L. V., Redick, J. A., Davis, C. A., Sisson, B. J., Patrie, J. T., Cotrim, H. P., Argo, C. K., et al. (2009) · Hepatology · doi:10.1002/hep.22851 · Cited by 75 · see citing works
Effect of Anaplerotic Fluxes and Amino Acid Availability on Hepatic Lipoapoptosis
Noguchi, Y., Young, J. D., Alemán, J. O., Hansen, M. A. E., Kelleher, J. K., & Stephanopoulos, G. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.049478 · Cited by 71 · see citing works
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
Burgess, S. C., Jeffrey, F. M. H., Storey, C. J., Milde, A., Hausler, N., Merritt, M. E., Mulder, H., Holm, C., Sherry, A. D., & Malloy, C. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00601.2004 · Cited by 71 · see citing works
Self-citationOrigin and utilization of volatile fatty acids in the rat
Rémésy, C., Demigné, C., & CHARTIER, F. (1980) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19800725 · Cited by 71 · see citing works
Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat
Choudhury, M., Jonscher, K. R., & Friedman, J. E. (2011) · Aging · doi:10.18632/aging.100289 · Cited by 69 · see citing works
Sherry, A. D., Jeffrey, F. M. H., & Malloy, C. R. (2003) · Metabolic Engineering · doi:10.1016/j.ymben.2003.10.007 · Cited by 62 · see citing works
Lieser, B., Liebisch, G., Drobnik, W., & Schmitz, G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.d300025-jlr200 · Cited by 62 · see citing works
Satapati, S., He, T., Inagaki, T., Potthoff, M. J., Merritt, M. E., Esser, V., Mangelsdorf, D. J., Kliewer, S. A., Browning, J. D., & Burgess, S. C. (2008) · Diabetes · doi:10.2337/db08-0226 · Cited by 52 · see citing works
Self-citationEffects of exercise on activity of heart and muscle mitochondria
Dohm, G. L., Huston, R. L., Askew, E., & Weiser, P. (1972) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1972.223.4.783 · Cited by 52 · see citing works
Buchner, D. A., Yazbek, S. N., Solinas, P., Burrage, L. C., Morgan, M. G., Hoppel, C. L., & Nadeau, J. H. (2010) · Obesity · doi:10.1038/oby.2010.214 · Cited by 45 · see citing works
Landau, B. R., Schumann, W. C., Chandramouli, V., Magnusson, I., Kumaran, K., & Wahren, J. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.4.e636 · Cited by 44 · see citing works
Browning, J. D., Weis, B. C., Davis, J., Satapati, S., Merritt, M. E., Malloy, C. R., & Burgess, S. C. (2008) · Hepatology · doi:10.1002/hep.22504 · Cited by 43 · see citing works
Self-citationBurgess, S. C., Nuss, M. E., Chandramouli, V., Hardin, D. S., Rice, M., Landau, B. R., Malloy, C. R., & Sherry, A. D. (2003) · Analytical Biochemistry · doi:10.1016/s0003-2697(03)00158-1 · Cited by 41 · see citing works
Self-citationPoussin, C., Ibberson, M. R., Hall, D., Ding, J., Soto, J. E., Abel, E. D., & Thorens, B. (2011) · Diabetes · doi:10.2337/db11-0338 · Cited by 40 · see citing works
Sequential Responses to High‐fat and High‐calorie Feeding in an Obese Mouse Model
Chan, M., Zhao, Y., & Heng, C. (2008) · Obesity · doi:10.1038/oby.2008.32 · Cited by 39 · see citing works
Pseudoketogenesis in hepatectomized dogs
Rosiers, C. D., Montgomery, J. A., Garneau, M., David, F., Mamer, O., Daloze, P., TOFFOLO, G. M., Cobelli, C., Landau, B. R., & Brunengraber, H. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.3.e519 · Cited by 25 · see citing works
Jin, E. S., Jones, J. G., Burgess, S. C., Merritt, M. E., Sherry, A. D., & Malloy, C. R. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20496 · Cited by 24 · see citing works
Self-citationValidation of two-pool model for in vivo ketone body kinetics
Bailey, J., Haymond, M. W., & Miles, J. M. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.5.e850 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 70 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics
Puchalska, P., & Crawford, P. A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.022 · Cited by 1,617 · see citing works
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
Chen, Z., Tian, R., She, Z., Cai, J., & Li, H. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.025 · Cited by 1,303 · see citing works
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,136 · see citing works
Morbidity and mortality associated with obesity
Abdelaal, M., le Roux, C. W., & Docherty, N. G. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.03.107 · Cited by 1,052 · see citing works
Koliaki, C., Szendroedi, J., Kaul, K., Jelenik, T., Nowotny, P., Jankowiak, F., Herder, C., Carstensen, M., Krausch, M., Knoefel, W. T., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.004 · Cited by 1,032 · see citing works
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
Kawano, Y., & Cohen, D. E. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0758-5 · Cited by 968 · see citing works
Ketone body metabolism and cardiovascular disease
Cotter, D. G., Schugar, R. C., & Crawford, P. A. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00646.2012 · Cited by 444 · see citing works
Leamy, A. K., Egnatchik, R. A., & Young, J. D. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.10.004 · Cited by 412 · see citing works
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver
Satapati, S., Kucejová, B., Duarte, J. A. G., Fletcher, J. A., Reynolds, L., Sunny, N. E., He, T., Nair, L. A., Livingston, K. A., Fu, X., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82204 · Cited by 400 · see citing works
Self-citationXu, X., Poulsen, K. L., Wu, L., Liu, S., Miyata, T., Song, Q., Wei, Q., Zhao, C., Lin, C., & Yang, J. B. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01119-3 · Cited by 370 · see citing works
Sunny, N. E., Bril, F., & Cusi, K. J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.11.006 · Cited by 321 · see citing works
Self-citationMetformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H., & Sakamoto, K. (2018) · Nature Medicine · doi:10.1038/s41591-018-0159-7 · Cited by 313 · see citing works
Hepatic glucose and lipid metabolism
Jones, J. G. (2016) · Diabetologia · doi:10.1007/s00125-016-3940-5 · Cited by 297 · see citing works
Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism
Jegatheesan, P., & Bandt, J. P. D. (2017) · Nutrients · doi:10.3390/nu9030230 · Cited by 280 · see citing works
Non-Alcoholic Fatty Liver Disease
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_19 · Cited by 247 · see citing works
Developmental origins of NAFLD: a womb with a clue
Wesolowski, S. R., Kasmi, K. C. E., Jonscher, K. R., & Friedman, J. E. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.160 · Cited by 231 · see citing works
McCommis, K. S., Chen, Z., Fu, X., McDonald, W. G., Colca, J. R., Kletzien, R. F., Burgess, S. C., & Finck, B. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.028 · Cited by 210 · see citing works
Self-citationEndoplasmic reticulum proteostasis in hepatic steatosis
Baiceanu, A., Mesdom, P., Lagouge, M., & Foufelle, F. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.124 · Cited by 212 · see citing works
Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia
Cotter, D. G., Erçal, B., Huang, X., Leid, J. M., d’Avignon, D. A., Graham, M. J., Dietzen, D. J., Brunt, E. M., Patti, G. J., & Crawford, P. A. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76388 · Cited by 199 · see citing works
Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver
Fletcher, J. A., Deja, S., Satapati, S., Fu, X., Burgess, S. C., & Browning, J. D. (2019) · JCI Insight · doi:10.1172/jci.insight.127737 · Cited by 195 · see citing works
Self-citationLandgraf, K., Schuster, S., Meusel, A., Garten, A., Riemer, T., Schleinitz, D., Kieß, W., & Körner, A. (2017) · BMC Physiology · doi:10.1186/s12899-017-0031-x · Cited by 185 · see citing works
Diet and exercise in NAFLD/NASH: Beyond the obvious
Semmler, G., Datz, C., Reiberger, T., & Trauner, M. A. (2021) · Liver International · doi:10.1111/liv.15024 · Cited by 183 · see citing works
Colca, J. R., McDonald, W. G., Cavey, G. S., Cole, S. L., Holewa, D. D., Brightwell-Conrad, A. S., Wolfe, C. L., Wheeler, J. S., Coulter, K. R., Kilkuskie, P. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061551 · Cited by 171 · see citing works
Duarte, J. A. G., Carvalho, F., Pearson, M. J., Horton, J. D., Browning, J. D., Jones, J. G., & Burgess, S. C. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m052308 · Cited by 171 · see citing works
Self-citationAlterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus
Koliaki, C. C., & Roden, M. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050656 · Cited by 167 · see citing works
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity
Patterson, R. E., Kalavalapalli, S., Williams, C. M., Nautiyal, M., Mathew, J. T., Martinez, J., Reinhard, M. K., McDougall, D. J., Rocca, J. R., Yost, R. A., et al. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00492.2015 · Cited by 161 · see citing works
Self-citationHepatic Fatty Acid Trafficking: Multiple Forks in the Road
Mashek, D. G. (2013) · Advances in Nutrition · doi:10.3945/an.113.004648 · Cited by 162 · see citing works
Egnatchik, R. A., Leamy, A. K., Jacobson, D. A., Shiota, M., & Young, J. D. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.004 · Cited by 160 · see citing works
Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance
Kakimoto, P. A., & Kowaltowski, A. J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.01.009 · Cited by 158 · see citing works
Lantier, L., Williams, A. S., Williams, I. M., Yang, K. K., Bracy, D. P., Goelzer, M., James, F. D., Gius, D., & Wasserman, D. H. (2015) · Diabetes · doi:10.2337/db14-1810 · Cited by 151 · see citing works
Egnatchik, R. A., Leamy, A. K., Noguchi, Y., Shiota, M., & Young, J. D. (2014) · Metabolism · doi:10.1016/j.metabol.2013.10.009 · Cited by 161 · see citing works
Wang, J., He, W., Tsai, P.-J., Chen, P.-H., Ye, M., Guo, J., & Su, Z. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01210-0 · Cited by 147 · see citing works
Portincasa, P., Khalil, M., Mahdi, L., Perniola, V., Idone, V., Graziani, A., Baffy, G., & Ciaula, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115640 · Cited by 152 · see citing works
High-Fat Diet Induces Dynamic Metabolic Alterations in Multiple Biological Matrices of Rats
An, Y., Xu, W., Li, H., Lei, H., Zhang, L., Hao, F., Duan, Y., Yan, X., Zhao, Y., Wu, J., et al. (2013) · Journal of Proteome Research · doi:10.1021/pr400398b · Cited by 139 · see citing works
Lipid metabolism in MASLD and MASH: From mechanism to the clinic
Carli, F., Della Pepa, G., Sabatini, S., Vidal Puig, A., & Gastaldelli, A. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101185 · Cited by 147 · see citing works
Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease
Koliaki, C. C., & Roden, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.002 · Cited by 136 · see citing works
Hepatic glucose metabolism in the steatotic liver
Scoditti, E., Sabatini, S., Carli, F., & Gastaldelli, A. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00888-8 · Cited by 134 · see citing works
Rafiei, H., Omidian, K., & Bandy, B. (2019) · Nutrients · doi:10.3390/nu11030541 · Cited by 130 · see citing works
A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD
Moore, M. P., Cunningham, R. P., Dashek, R. J., Mucinski, J. M., & Rector, R. S. (2020) · Obesity · doi:10.1002/oby.22964 · Cited by 128 · see citing works
Role of mitochondria in liver metabolic health and diseases
Morio, B., Panthu, B., Bassot, A., & Rieusset, J. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102336 · Cited by 130 · see citing works
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis
Asif, S., Kim, R. Y., Fatica, T., Sim, J., Zhao, X., Oh, Y., Denoncourt, A. M., Cheung, A., Downey, M., Mulvihill, E. E., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101494 · Cited by 122 · see citing works
Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
Goossens, C., Weckx, R., Derde, S., Dufour, T., Perre, S. V., Pauwels, L., Thiessen, S., Veldhoven, P. P. V., den Berghe, G. V., & Langouche, L. (2019) · Critical Care · doi:10.1186/s13054-019-2506-6 · Cited by 118 · see citing works
The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?
Bender, T., & Martinou, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.017 · Cited by 117 · see citing works
Metabolic Changes of Hepatocytes in NAFLD
Lu, Q., Tian, X., Wu, H., Huang, J., Li, M., Mei, Z., Zhou, L., Xie, H., & Zheng, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.710420 · Cited by 113 · see citing works
Exercise Combats Hepatic Steatosis: Potential Mechanisms and Clinical Implications
Thyfault, J. P., & Rector, R. S. (2020) · Diabetes · doi:10.2337/dbi18-0043 · Cited by 111 · see citing works
Sunny, N. E., Kalavalapalli, S., Bril, F., Garrett, T. J., Nautiyal, M., Mathew, J. T., Williams, C. M., & Cusi, K. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00161.2015 · Cited by 106 · see citing works
Self-citationMeex, R. C. R., & Blaak, E. E. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900942 · Cited by 108 · see citing works
Legaki, A., Moustakas, I. I., Sikorska, M., Papadopoulos, G., Velliou, R.-I., & Chatzigeorgiou, A. (2022) · Current Obesity Reports · doi:10.1007/s13679-022-00473-1 · Cited by 108 · see citing works
NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis
Gansemer, E. R., McCommis, K. S., Martino, M. R., King-McAlpin, A. Q., Potthoff, M. J., Finck, B. N., Taylor, E. B., & Rutkowski, D. T. (2020) · iScience · doi:10.1016/j.isci.2020.101116 · Cited by 96 · see citing works
Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
Haus, J. M., Solomon, T. P. J., Kelly, K. R., Fealy, C. E., Kullman, E. L., Scelsi, A. R., Lu, L., Pagadala, M. R., McCullough, A. J., Flask, C. A., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1229 · Cited by 100 · see citing works
Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster
Heinrichsen, E. T., Zhang, H., Robinson, J. E., Ngo, J. T., Diop, S. B., Bodmer, R., Joiner, W. J., Metallo, C. M., & Haddad, G. G. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.003 · Cited by 97 · see citing works
Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins
Giménez-Cassina, A., & Danial, N. N. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.02.004 · Cited by 96 · see citing works
Different Serum Free Fatty Acid Profiles in NAFLD Subjects and Healthy Controls after Oral Fat Load
Gambino, R., Bugianesi, E., Rosso, C., Mezzabotta, L., Pinach, S., Alemanno, N., Saba, F., & Cassader, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040479 · Cited by 101 · see citing works
Stevanović, J., Beleza, J., Coxito, P. M., Ascensão, A. A. M. R., & Magalhães, J. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.015 · Cited by 96 · see citing works
Rusli, F., Deelen, J., Andriyani, E., Boekschoten, M. V., Lute, C., van den Akker, E. B., Müller, M. M., Beekman, M., & Steegenga, W. T. (2016) · Scientific Reports · doi:10.1038/srep30484 · Cited by 93 · see citing works
Jin, S., Jiang, S., & Hu, A. (2018) · Sleep And Breathing · doi:10.1007/s11325-018-1625-7 · Cited by 93 · see citing works
Mitochondrial Dysfunction in the Transition from NASH to HCC
Léveillé, M., & Estall, J. L. (2019) · Metabolites · doi:10.3390/metabo9100233 · Cited by 93 · see citing works
Valenzuela, R., Barrera, C. R., Espinosa, A., Llanos, P., Orellana, P., & Videla, L. A. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.04.002 · Cited by 90 · see citing works
Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome
d’Avignon, D. A., Puchalska, P., Erçal, B., Chang, Y., Martin, S. E., Graham, M. J., Patti, G. J., Han, X., & Crawford, P. A. (2018) · JCI Insight · doi:10.1172/jci.insight.99762 · Cited by 90 · see citing works
Oxidative Stress in Non-Alcoholic Fatty Liver Disease
Smirne, C., Croce, E., Benedetto, D. D., Cantaluppi, V., Comi, C., Sainaghi, P. P., Minisini, R., Grossini, E., & Pirisi, M. (2022) · Livers · doi:10.3390/livers2010003 · Cited by 92 · see citing works
Santamarina, A. B., Carvalho‐Silva, M., Gomes, L. M., Okuda, M. H., de Santana, A. A., STRECK, E. L., Seelaender, M. C. L., do Nascimento, C. M. O., Ribeiro, E. B., Lira, F. S., et al. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.002 · Cited by 88 · see citing works
Chang, H., Meng, H.-Y., Liu, S., Wang, Y., Yang, X., Lu, F., & Wang, H.-Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-11759-z · Cited by 88 · see citing works
Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease
Mooli, R. G. R., & Ramakrishnan, S. K. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.946474 · Cited by 84 · see citing works
Echeverría, F., Valenzuela, R., Bustamante, A., Álvarez, D., Ortíz, M., Espinosa, A., Illesca, P., Gonzalez‐Mañán, D., & Videla, L. A. (2019) · Food & Function · doi:10.1039/c9fo01373c · Cited by 86 · see citing works
Mitochondrial genome architecture in non‐alcoholic fatty liver disease
Sookoian, S. C., Flichman, D. M., Scian, R., Rohr, C., Dopazo, H., Gianotti, T. F., Martino, J. S., Castaño, G. O., & Pirola, C. J. (2016) · The Journal of Pathology · doi:10.1002/path.4803 · Cited by 86 · see citing works
Le, L., Jiang, B., Wan, W., Zhai, W., Xu, L., Hu, K., & Xiao, P. (2016) · Scientific Reports · doi:10.1038/srep36184 · Cited by 87 · see citing works
Rincón‐Cervera, M. Á., Valenzuela, R., Hernández‐Rodas, M. C., Marambio, M., Espinosa, A., Mayer, S., Romero, N., Barrera, C. R., Valenzuela, A., & Videla, L. A. (2016) · Nutrition · doi:10.1016/j.nut.2016.04.006 · Cited by 83 · see citing works
Williams, K. J., & Wu, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.004 · Cited by 81 · see citing works
Mitochondrial heterogeneity in diseases
Chen, L., Zhou, M., Li, H., Liu, D., Liao, P., Yao, Z., Zhang, C., Zou, W., & Gao, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01546-w · Cited by 85 · see citing works
Rahim, M., Ragavan, M., Deja, S., Merritt, M. E., Burgess, S. C., & Young, J. D. (2021) · Metabolic Engineering · doi:10.1016/j.ymben.2021.12.009 · Cited by 80 · see citing works
Self-citationHasenour, C. M., Wall, M. L., Ridley, D. E., Hughey, C. C., James, F. D., Wasserman, D. H., & Young, J. D. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00003.2015 · Cited by 80 · see citing works
Zhang, W., Bu, S. Y., Mashek, M. T., O‐Sullivan, I., Sibai, Z., Khan, S. A., Ilkayeva, O., Newgard, C. B., Mashek, D. G., & Unterman, T. G. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.021 · Cited by 80 · see citing works
Tompkins, S. C., Sheldon, R. D., Rauckhorst, A. J., Noterman, M. F., Solst, S. R., Buchanan, J. L., Mapuskar, K. A., Pewa, A. D., Gray, L. R., Oonthonpan, L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.098 · Cited by 79 · see citing works
Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD
Giménez-Cassina, A., García-Haro, L., Choi, C. S., Osundiji, M. A., Lane, E. A., Hu, H., Yıldırım, M. A., Szlyk, B., Fisher, J. K., Polak, K. Z., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.001 · Cited by 77 · see citing works
Go, Y., Jeong, J. Y., Jeoung, N. H., Jeon, J., Park, B.-Y., Kang, H., Ha, C., Choi, Y., Lee, S. J., Ham, H. J., et al. (2016) · Diabetes · doi:10.2337/db16-0223 · Cited by 77 · see citing works
Protective effect of metformin against palmitate-induced hepatic cell death
Geng, Y., Villanueva, A. H., Oun, A., Buist‐Homan, M., Blokzijl, H., Faber, K. N., Dolga, A. M., & Moshage, H. J. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165621 · Cited by 76 · see citing works
Dallio, M., Sangineto, M., Romeo, M., Villani, R., Romano, A. D., Loguercio, C., Serviddio, G., & Federico, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010436 · Cited by 77 · see citing works
Massey, V. L., Parrish, A., Argemí, J., Moreno, M., Mello, A., Garcı́a-Rocha, M., Altamirano, J., Òdena, G., Dubuquoy, L., Louvet, A., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.12.008 · Cited by 73 · see citing works
Potential Role of Oxidative Stress in the Production of Volatile Organic Compounds in Obesity
Oyerinde, A. S., Selvaraju, V., Babu, J. R., & Geetha, T. (2023) · Antioxidants · doi:10.3390/antiox12010129 · Cited by 73 · see citing works
Undamatla, R., Fagunloye, O. G., Chen, J., Edmunds, L. R., Murali, A., Mills, A. S., Xie, B., Pangburn, M. M., SIPULA, I. J., Gibson, G. A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-34710-x · Cited by 69 · see citing works
Moreno, K. X., Satapati, S., DeBerardinis, R. J., Burgess, S. C., Malloy, C. R., & Merritt, M. E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.613265 · Cited by 69 · see citing works
Self-citationKhan, S. A., Wollaston-Hayden, E. E., Markowski, T. W., Higgins, L., & Mashek, D. G. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m056812 · Cited by 64 · see citing works
Latorre‐Muro, P., Baeza, J., Armstrong, E. A., Hurtado‐Guerrero, R., Corzana, F., Wu, L. E., Sinclair, D. A., López‐Buesa, P., Carrodeguas, J. A., & Denu, J. M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.031 · Cited by 67 · see citing works
Mueller, K. M., Hartmann, K., Kaltenecker, D., Vettorazzi, S., Bauer, M., Mauser, L., Amann, S., Jall, S., Fischer, K., Esterbauer, H., et al. (2016) · Diabetes · doi:10.2337/db16-0381 · Cited by 66 · see citing works
Kalavalapalli, S., Bril, F., Koelmel, J. P., Abdo, K. I., Guingab, J., Andrews, P. M., Li, W., Jose, D., Yost, R. A., Frye, R. F., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00023.2018 · Cited by 66 · see citing works
Self-citationGutiérrez‐Cuevas, J., Lucano‐Landeros, S., López-Cifuentes, D., Santos, A., & Armendáriz‐Borunda, J. (2022) · Cancers · doi:10.3390/cancers15010023 · Cited by 62 · see citing works
Garcia‐Berumen, C. I., Ortiz‐Avila, O., Vargas-Vargas, M. A., del Rosario-Tamayo, B. A., Guajardo-López, C., Saavedra‐Molina, A., Rodríguez-Orozco, A. R., & Cortés‐Rojo, C. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1024-5 · Cited by 62 · see citing works
Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease
Baker, P. R., & Friedman, J. E. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120846 · Cited by 61 · see citing works
Tsilingiris, D., Tzeravini, E., Koliaki, C. C., Dalamaga, Μ., & Kokkinos, A. D. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00434-0 · Cited by 60 · see citing works
Perry, R. J., Peng, L., Cline, G. W., Butrico, G. M., Wang, Y., Zhang, X., Rothman, D. L., Petersen, K. F., & Shulman, G. I. (2017) · Nature Communications · doi:10.1038/s41467-017-01143-w · Cited by 61 · see citing works
Shannon, C. E., Ragavan, M., Palavicini, J. P., Fourcaudot, M. J., Bakewell, T. M., Valdez, I., Ayala, I., Jin, E. S., Madesh, M., Han, X., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101154 · Cited by 61 · see citing works
Gancheva, S., Kahl, S., Pesta, D., Mastrototaro, L., Dewidar, B., Strassburger, K., Sabah, E., Esposito, I., Weiß, J., Sarabhai, T., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1758 · Cited by 60 · see citing works
Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis
Overi, D., Carpino, G., Franchitto, A., Onori, P., & Gaudio, E. (2020) · Cells · doi:10.3390/cells9030590 · Cited by 61 · see citing works
Nayak, N., & Mishra, M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119758 · Cited by 59 · see citing works
Guerra, S., Mocciaro, G., & Gastaldelli, A. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13695 · Cited by 60 · see citing works
Integrated omics analysis reveals the alteration of gut microbe–metabolites in obese adults
Li, R., Huang, X., Xiao, L., Su, M., Lai, K. P., & Chen, J. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa165 · Cited by 59 · see citing works
Simões, I. C. M., Amorim, R., Teixeira, J., Karkucińska‐Więckowska, A., Carvalho, A., Pereira, S. P., Simões, R. F., Szymańska, S., Dąbrowski, M., Janikiewicz, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136848 · Cited by 59 · see citing works
High‐Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in Drosophila melanogaster
de Paula, M. T., Poetini, M. R., Araújo, S. M., Bortolotto, V. C., Meichtry, L. B., Zemolin, A. P. P., Wallau, G. L., Jessé, C. R., Franco, J. L., Posser, T., et al. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4018157 · Cited by 57 · see citing works
High Protein Diet and Metabolic Plasticity in Non-Alcoholic Fatty Liver Disease: Myths and Truths
Chiara, F. D., Checcllo, C. U., & Ramón‐Azcón, J. (2019) · Nutrients · doi:10.3390/nu11122985 · Cited by 57 · see citing works
- Authors
- Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., & Burgess, S. C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Universitat de Barcelona (ES)
- Corresponding author
- Burgess, Shawn C.
- ORCID
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 53
- Issue
- 6
- Pages
- 1080-1092
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC3351815
- OpenAlex
- W2036097574
- Cited by
- 407
- References
- 70
- Citations by year
- 2026: 19 · 2025: 33 · 2024: 23 · 2023: 41 · 2022: 35 · 2021: 30 · 2020: 44 · 2019: 36 · 2018: 25 · 2017: 24 · 2016: 31 · 2015: 23 · 2014: 22 · 2013: 17 · 2012: 2
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK058398, R01DK087977, R01DK078184)
- National Institute of Dental and Craniofacial Research (UL1DE019584)
- National Center for Research Resources (P41RR002584, RR‐02584)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- TCA cycle, hepatic insulin resistance, high-fat diet, mitochondrial dysfunction, mitochondrial respiration, fat oxidation, ketogenesis, gluconeogenesis, oxidative stress, inflammation, insulin signaling, reactive oxygen species, mitochondrial beta-oxidation
- MeSH terms
- Animals, Citric Acid Cycle, Fatty Liver, Gluconeogenesis, Hyperglycemia, Insulin Resistance, Ketone Bodies, Liver, Male, Mice, Inbred C57BL, Mitochondria, Obesity, Time Factors, Oxidative Stress, Cell Respiration, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
