Fairall, Louise

Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate

Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 505

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

Millard, C. J., Watson, P. J., Celardo, I., Gordiyenko, Y., Cowley, S. M., Robinson, C. V., Fairall, L., & Schwabe, J. W. R. (2013) · Molecular Cell

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 396

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Dickens, L. S., Boyd, R. S., Jukes-Jones, R., Hughes, M. A., Robinson, G. L., Fairall, L., Schwabe, J. W. R., Cain, K., & MacFarlane, M. (2012) · Molecular Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 349

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Sandhu, J., Li, S., Fairall, L., Pfisterer, S. G., Gurnett, J. E., Xiao, X., Weston, T. A., Vashi, D., Ferrari, A., Orozco, J. L., et al. (2018) · Cell

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 287

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Hughes, M. A., Powley, I. R., Jukes-Jones, R., Horn, S., Feoktistova, M., Fairall, L., Schwabe, J. W. R., Leverkus, M., Cain, K., & MacFarlane, M. (2016) · Molecular Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 257

TRF1 binds a bipartite telomeric site with extreme spatial flexibility

Bianchi, A., Stansel, R. M., Fairall, L., Griffith, J. D., Rhodes, D., & de Lange, T. (1999) · The EMBO Journal

Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

Cited by 217

Targeting Class I Histone Deacetylases in a “Complex” Environment

Millard, C. J., Watson, P. J., Fairall, L., & Schwabe, J. W. R. (2017) · Trends in Pharmacological Sciences

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 180

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

Oberoi, J., Fairall, L., Watson, P. J., Yang, J.-C., Czimmerer, Z., Kampmann, T., Goult, B. T., Greenwood, J. A., Gooch, J. T., Kallenberger, B. C., et al. (2011) · Nature Structural & Molecular Biology

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 165

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

Turnbull, R. E., Fairall, L., Saleh, A., Kelsall, E., Morris, K. L., Ragan, T. J., Savva, C. G., Chandru, A., Millard, C. J., Makarova, O. V., et al. (2020) · Nature Communications

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 108

Mutations in TBL1X Are Associated With Central Hypothyroidism

Heinen, C. A., Losekoot, M., Sun, Y., Watson, P. J., Fairall, L., Joustra, S. D., Zwaveling-Soonawala, N., Oostdijk, W., van den Akker, E. L. T., Alders, M., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGenomics and Rare Diseases

Cited by 92

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Zhang, L., Fairall, L., Goult, B. T., Calkin, A. C., Hong, C., Millard, C. J., Tontonoz, P., & Schwabe, J. W. R. (2011) · Genes & Development

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 86

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

Calkin, A. C., Goult, B. T., Zhang, L., Fairall, L., Hong, C., Schwabe, J. W. R., & Tontonoz, P. (2011) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 62

Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake

Ferrari, A., Whang, E., Xiao, X., Kennelly, J. P., Romartinez-Alonso, B., Mack, J. J., Weston, T., Chen, K., Kim, Y., Tol, M. J., et al. (2023) · Science

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 61

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins

Moran, C., Agostini, M., McGowan, A., Schoenmakers, E., Fairall, L., Lyons, G., Rajanayagam, O., Watson, L., Offiah, A., Barton, J., et al. (2017) · Thyroid®

Thyroid Disorders and TreatmentsGenomics and Rare Diseases

Cited by 60

Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation

Alshehri, A., Baker, I.-M., English, D. M., Fairall, L., Collins, M. O., Schwabe, J. W., & Cowley, S. M. (2025) · Nucleic Acids Research

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 5

Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation

Alshehri, A., Baker, I.-M., English, D. M., Fairall, L., Collins, M. O., Schwabe, J. W. R., & Cowley, S. M. (2025) · Nucleic Acids Research

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 5