Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery
Open accessAbstract
Eukaryotic transcriptional repressors function by recruiting large coregulatory complexes that target histone deacetylase enzymes to gene promoters and enhancers. Transcriptional repression complexes, assembled by the corepressor NCoR and its homolog SMRT, are crucial in many processes, including development and metabolic physiology. The core repression complex involves the recruitment of three proteins, HDAC3, GPS2 and TBL1, to a highly conserved repression domain within SMRT and NCoR. We have used structural and functional approaches to gain insight into the architecture and biological role of this complex. We report the crystal structure of the tetrameric oligomerization domain of TBL1, which interacts with both SMRT and GPS2, and the NMR structure of the interface complex between GPS2 and SMRT. These structures, together with computational docking, mutagenesis and functional assays, reveal the assembly mechanism and stoichiometry of the corepressor complex.
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HDAC3 appears to be uniquely recruited to the SMRT/NCoR complex, where it interacts with a conserved deacetylase-activation-domain (DAD) within SMRT or NCoR.
“In contrast, HDAC3 appears to be uniquely recruited to the SMRT/NCoR complex where it interacts with a conserved deacetylase-activation-domain (DAD) within SMRT or NCoR8,10,12,24,25,26.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [26]
The introductory passage labelled Abstract (page unavailable) says HDAC3 is recruited to the SMRT/NCoR complex and interacts with the SMRT deacetylase activation domain. It also says the complexes associate with multiple histone deacetylases, so it does not establish that HDAC3 is uniquely recruited. The passage does not explicitly describe an interaction with the NCoR DAD. (LLM, conf=0.85)
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Cites
<i>Coot</i> : model-building tools for molecular graphics
Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571 · see citing works
<i>Phaser</i> crystallographic software
McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., & Read, R. J. (2007) · Journal of Applied Crystallography · doi:10.1107/s0021889807021206 · Cited by 20,612 · see citing works
The CCP4 suite: programs for protein crystallography
Number Collaborative Computational Project (1994) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444994003112 · Cited by 17,299 · see citing works
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
Murshudov, G. N., Vagin, A. A., & Dodson, E. J. (1997) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444996012255 · Cited by 14,671 · see citing works
HADDOCK: A Protein−Protein Docking Approach Based on Biochemical or Biophysical Information
Dominguez, C., Boelens, R., & Bonvin, A. M. J. J. (2003) · Journal of the American Chemical Society · doi:10.1021/ja026939x · Cited by 3,187 · see citing works
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works
Barroso, I., Gurnell, M., Crowley, V. E. F., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D. M., Lewis, H., Schafer, A. J., et al. (1999) · Nature · doi:10.1038/47254 · Cited by 1,368 · see citing works
Self-citationGenome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., & Zhao, K. (2009) · Cell · doi:10.1016/j.cell.2009.06.049 · Cited by 1,344 · see citing works
The integration of macromolecular diffraction data
Leslie, A. G. W. (2005) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444905039107 · Cited by 1,341 · see citing works
Version 1.2 of the Crystallography and NMR system
Brünger, A. T. (2007) · Nature Protocols · doi:10.1038/nprot.2007.406 · Cited by 1,335 · see citing works
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works
Self-citationA complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210 · see citing works
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707 · see citing works
Integration of macromolecular diffraction data
Leslie, A. G. W. (2006) · International Tables for Crystallography · doi:10.1107/97809553602060000675 · Cited by 703 · see citing works
Both corepressor proteins SMRT and N‐CoR exist in large protein complexes containing HDAC3
Li, J., Wang, J., Wang, J., Nawaz, Z., Liu, J. M., Qin, J., & Wong, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.16.4342 · Cited by 629 · see citing works
The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3
Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611 · see citing works
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint
Kao, H., Ordentlich, P., Koyano‐Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579 · see citing works
Perissi, V., Aggarwal, A. K., Glass, C. K., Rose, D. W., & Rosenfeld, M. G. (2004) · Cell · doi:10.1016/s0092-8674(04)00133-3 · Cited by 566 · see citing works
Combinatorial roles of the nuclear receptor corepressor in transcription and development.
Jepsen, K., Hermanson, O., Onami, T. M., Gleiberman, A., Lunyak, V., Mcevilly, R., Kurokawa, R., Kumar, V., Liu, F. C., Seto, E., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00064-7 · Cited by 545 · see citing works
Gelmetti, V., Zhang, J., Fanelli, M., Minucci, S., Pelicci, P. G., & Lazar, M. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7185 · Cited by 489 · see citing works
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
Guenther, M. G., Lane, W. S., Fischle, W., Verdin, E., Lazar, M. A., & Shiekhattar, R. (2000) · Genes & Development · doi:10.1101/gad.14.9.1048 · Cited by 489 · see citing works
Yoon, H., Chan, D. W., Huang, Z., Li, J., Fondell, J. D., Qin, J., & Wong, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg120 · Cited by 444 · see citing works
Groucho/TLE family proteins and transcriptional repression.
Chen, G.-Q., & Courey, A. (2000) · Gene · doi:10.1016/s0378-1119(00)00161-x · Cited by 437 · see citing works
ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors
Lutterbach, B. A., Westendorf, J. J., Linggi, B. E., Patten, A. K., Moniwa, M., Davie, J., Huynh, K. D., Bardwell, V. J., Lavinsky, R. M., Rosenfeld, M. G., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7176 · Cited by 431 · see citing works
Zhang, J., Kalkum, M., Chait, B. T., & Roeder, R. G. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00468-9 · Cited by 414 · see citing works
N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso
Yoon, H.-G., Chan, D. W., Reynolds, A. B., Qin, J., & Wong, J. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.008 · Cited by 408 · see citing works
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
Jepsen, K., Solum, D., Zhou, T., McEvilly, R. J., Kim, H., Glass, C. K., Hermanson, O., & Rosenfeld, M. G. (2007) · Nature · doi:10.1038/nature06270 · Cited by 399 · see citing works
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Y.-D., Perissi, V., Staszewski, L. M., Yang, W.-M., Krones, A., Glass, C. K., Rosenfeld, M. G., & Seto, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7202 · Cited by 378 · see citing works
Hong, S.-H., David, G., Wong, C.-W., Dejean, A., & Privalsky, M. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9028 · Cited by 341 · see citing works
Mechanism of SMRT Corepressor Recruitment by the BCL6 BTB Domain
Ahmad, K. F., Melnick, A. M., Lax, S. A., Bouchard, D., Liu, J., Kiang, C. L., Mayer, S., Takahashi, S., Licht, J. D., & Privé, G. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00454-4 · Cited by 282 · see citing works
Molecular recognition of histone H3 by the WD40 protein WDR5
Couture, J., Collazo, E., & Trievel, R. C. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1116 · Cited by 256 · see citing works
Ghisletti, S., Huang, W. J. M., Jepsen, K., Benner, C. W., Hardiman, G., Rosenfeld, M. G., & Glass, C. K. (2009) · Genes & Development · doi:10.1101/gad.1773109 · Cited by 249 · see citing works
Li, J., & Wang, C. (2008) · Nature Cell Biology · doi:10.1038/ncb1684 · Cited by 189 · see citing works
Structural basis of histone H4 recognition by p55Preprint
Song, J., Garlick, J. D., & Kingston, R. E. (2008) · Genes & Development · doi:10.1101/gad.1653308 · Cited by 153 · see citing works
Melnick, A. M., Westendorf, J. J., Polinger, A., Carlile, G. W., Arai, S., Ball, H. J., Lutterbach, B. A., Hiebert, S. W., & Licht, J. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2075-2086.2000 · Cited by 152 · see citing works
Kim, M. H., Cooper, D. R., Oleksy, A., et al. (2004) · Structure · doi:10.1016/j.str.2004.03.024 · Cited by 134 · see citing works
The Cyc8 (Ssn6)-Tup1 Corepressor Complex Is Composed of One Cyc8 and Four Tup1 Subunits
Varanasi, U. S., Klis, M., Mikesell, P. B., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6707 · Cited by 134 · see citing works
Jakobsson, T., Venteclef, N., Toresson, G., Damdimopoulos, A. E., Ehrlund, A., Lou, X., Sanyal, S., Steffensen, K. R., Gustafsson, J.-Α., & Treuter, E. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.006 · Cited by 131 · see citing works
The design of antiparallel coiled coils
Oakley, M. G. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00232-3 · Cited by 131 · see citing works
Li, J., Lin, Q., Wang, W., Wade, P. A., & Wong, J. (2002) · Genes & Development · doi:10.1101/gad.962502 · Cited by 126 · see citing works
Tomita, A., Buchholz, D. R., & Shi, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3337-3346.2004 · Cited by 116 · see citing works
Codina, A., Love, J. D., Li, Y., Lazar, M. A., Neuhaus, D., & Schwabe, J. W. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500299102 · Cited by 95 · see citing works
Self-citationLazar, M. A. (2003) · Nuclear Receptor Signaling · doi:10.1621/nrs.01001 · Cited by 94 · see citing works
Gerlitz, G., Darhin, E., Giorgio, G., Franco, B., & Reiner, O. (2005) · Cell Cycle · doi:10.4161/cc.4.11.2151 · Cited by 92 · see citing works
Cheng, G.-X., Zhu, X., Men, X.-Q., Wang, L., Huang, Q. H., Jin, X. L., Xiong, S.-M., Zhu, J., Guo, W.-M., Chen, J.-Q., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6318 · Cited by 91 · see citing works
AMF-1/Gps2 Binds p300 and Enhances Its Interaction with Papillomavirus E2 Proteins
Peng, Y.-C., Breiding, D. E., Sverdrup, F. M., Richard, J. G., & Androphy, E. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.5872-5879.2000 · Cited by 86 · see citing works
Hartman, H. B., Yu, J., Alenghat, T., Ishizuka, T., & Lazar, M. A. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400391 · Cited by 82 · see citing works
AMF1 (GPS2) Modulates p53 Transactivation
Peng, Y., Kuo, F., Breiding, D. E., Wang, Y., Mansur, C. P., & Androphy, E. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5913-5924.2001 · Cited by 62 · see citing works
SMRTe Inhibits MEF2C Transcriptional Activation by Targeting HDAC4 and 5 to Nuclear Domains
Wu, X., Li, H., Park, E.-J., & Chen, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100412200 · Cited by 59 · see citing works
Gps2, a Protein Partner for Human Papillomavirus E6 Proteins
Degenhardt, Y., & Silverstein, S. J. (2001) · Journal of Virology · doi:10.1128/jvi.75.1.151-160.2001 · Cited by 57 · see citing works
The Structure of Sif2p, a WD Repeat Protein Functioning in the SET3 Corepressor Complex
Cerna, D., & Wilson, D. K. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.06.025 · Cited by 54 · see citing works
Ishizuka, T., & Lazar, M. A. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0009 · Cited by 50 · see citing works
Mikolajka, A., Yan, X., Popowicz, G. M., et al. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.03.070 · Cited by 40 · see citing works
Jayne, S., Zwartjes, C. G. M., van Schaik, F. M. A., & Timmers, H. T. M. (2006) · Biochemical Journal · doi:10.1042/bj20060406 · Cited by 39 · see citing works
Zhang, D., Harry, G. J., Blackshear, P. J., & Zeldin, D. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708209200 · Cited by 32 · see citing works
Formation of hMSH4–hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment
Lee, T., Yi, W., Griswold, M. D., Zhu, F., & Her, C. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.07.004 · Cited by 31 · see citing works
Yan, H.-T., Shinka, T., Kinoshita, K., Sato, Y., Umeno, M., Chen, G., Tsuji, K., Unemi, Y., Yang, X.-J., Iwamoto, T., et al. (2005) · Journal of Human Genetics · doi:10.1007/s10038-005-0237-9 · Cited by 30 · see citing works
Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation
Varlakhanova, N., Hahm, J. B., & Privalsky, M. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.10.010 · Cited by 24 · see citing works
Choi, H.-K., Choi, K., Kang, H., Kim, H.-C., Lee, Y.-H., Haam, S., Park, H.-G., & Yoon, H. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0396 · Cited by 23 · see citing works
Bag‐1M inhibits the transactivation of the glucocorticoid receptor via recruitment of corepressors
Wei, H., Baniahmad, A., Li, J., Cheng-lin, C., Gao, W., & Liu, Y. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.010 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [11]Barroso I Dominant negative mutations in human PPARgamma associated with severe insulin resistance Nature 1999 402 880 883 10622252
- [36]Choi HK Function of Multiple LisH/WD-40 Repeat-Containing Proteins in Feed-Forward Transcriptional Repression by SMRT/N-CoR Corepressor Complexes Mol Endocrinol 2008 18202150 PMC5419524
- [57]McCoy AJ Phaser crystallographic software J Appl Crystallogr 2007 40 658 674 19461840 PMC2483472
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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
Pugh, T. J., Weeraratne, S. D., Archer, T. C., Pomeranz Krummel, D. A., Auclair, D., Bochicchio, J., Carneiro, M. O., Carter, S. L., Cibulskis, K., Erlich, R. L., et al. (2012) · Nature · doi:10.1038/nature11329 · Cited by 750 · see citing works
Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate
Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505 · see citing works
Self-citationRetinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403 · see citing works
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
Mottis, A., Mouchiroud, L., & Auwerx, J. (2013) · Genes & Development · doi:10.1101/gad.214023.113 · Cited by 297 · see citing works
Thyroid hormone signaling and the liver
Ritter, M. J., Amano, I., Hollenberg, A. N., et al. (2020) · Hepatology · doi:10.1002/hep.31296 · Cited by 188 · see citing works
Targeting Class I Histone Deacetylases in a “Complex” Environment
Millard, C. J., Watson, P. J., Fairall, L., & Schwabe, J. W. R. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.12.006 · Cited by 180 · see citing works
Self-citationTBL1XR1 mutations drive extranodal lymphoma by inducing a pro-tumorigenic memory fate
Venturutti, L., Teater, M., Zhai, A., Chadburn, A., Babiker, L., Kim, D., Béguelin, W., Lee, T. C., Kim, Y., Chin, C. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.049 · Cited by 127 · see citing works
Turnbull, R. E., Fairall, L., Saleh, A., Kelsall, E., Morris, K. L., Ragan, T. J., Savva, C. G., Chandru, A., Millard, C. J., Makarova, O. V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17078-8 · Cited by 108 · see citing works
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Self-citationThe in vivo role of nuclear receptor corepressors in thyroid hormone action
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Paton, K. M., Alexander-Howden, B., Hare, J. I., Guy, J., Chhatbar, K., Yudina, M., Morris, S. T., Walls, R., Mathieson, T., Spanos, C., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73227-5
- Authors
- Oberoi, J., Fairall, L., Watson, P. J., Yang, J.-C., Czimmerer, Z., Kampmann, T., Goult, B. T., Greenwood, J. A., Gooch, J. T., Kallenberger, B. C., Nagy, L., Neuhaus, D., & Schwabe, J. W. R.
- Affiliations
- University of Leicester (GB)
- MRC Laboratory of Molecular Biology (GB)
- University of Debrecen (HU)
- Corresponding author
- Schwabe, John W R
- Venue
- Nature Structural & Molecular Biology
- Published
- 2011-01-16
- Volume
- 18
- Issue
- 2
- Pages
- 177-184
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC3232451
- OpenAlex
- W2064488190
- Cited by
- 165
- References
- 61
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 21 · 2019: 12 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 13 · 2012: 13
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- Wellcome Trust (085408)
- European Synchrotron Radiation Facility
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- SMRT, NCoR, corepressor complex, transcriptional repression, TBL1, GPS2, HDAC3, histone deacetylase, protein complex formation, oligomerization domain, crystal structure, NMR structure, protein-protein interaction, stoichiometry
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Humans, Models, Molecular, Molecular Sequence Data, Protein Binding, Transducin, Protein Structure, Tertiary, Crystallography, X-Ray, Nuclear Magnetic Resonance, Biomolecular, Amino Acid Motifs, Intracellular Signaling Peptides and Proteins, Mice, Protein Multimerization, Nuclear Receptor Co-Repressor 2
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