Hollingsworth, Kieren G.

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2018) · The Lancet

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 2,095

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Lim, E. L., Hollingsworth, K. G., Aribisala, B. S., Chen, M. J., Mathers, J. C., & Taylor, R. (2011) · Diabetologia

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 1,164

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial

Lean, M. E. J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2019) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,017

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss

Hallsworth, K., Fattakhova, G., Hollingsworth, K. G., Thoma, C., Moore, S., Taylor, R., Day, C. P., & Trenell, M. I. (2011) · Gut

Liver Disease Diagnosis and TreatmentPhysical Activity and Health

Cited by 529

Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery

Taylor, R., Al-Mrabeh, A., Zhyzhneuskaya, S., Peters, C., Barnes, A. C., Aribisala, B. S., Hollingsworth, K. G., Mathers, J. C., Sattar, N., & Lean, M. E. J. (2018) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 450

Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders

Steven, S., Hollingsworth, K. G., Al-Mrabeh, A., Avery, L., Aribisala, B., Caslake, M., & Taylor, R. (2016) · Diabetes Care

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 418

Exercise Reduces Liver Lipids and Visceral Adiposity in Patients With Nonalcoholic Steatohepatitis in a Randomized Controlled Trial

Houghton, D., Thoma, C., Hallsworth, K., Cassidy, S., Hardy, T., Burt, A. D., Tiniakos, D., Hollingsworth, K. G., Taylor, R., Day, C. P., et al. (2017) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentPhysical Activity and Health

Cited by 209

Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial

Hallsworth, K., Thoma, C., Hollingsworth, K. G., Cassidy, S., Anstee, Q. M., Day, C. P., & Trenell, M. I. (2015) · Clinical Science

Liver Disease Diagnosis and TreatmentCardiovascular and exercise physiology

Cited by 201

5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study

Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Kelly, T., Irvine, K., Peters, C., Zhyzhneuskaya, S., et al. (2024) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementBariatric Surgery and Outcomes

Cited by 186

Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology†

Newton, J. L., Hollingsworth, K. G., Taylor, R., El‐Sharkawy, A. M., Khan, Z. U., Pearce, R., Sutcliffe, K., Okonkwo, O., Davidson, A., Burt, J., et al. (2008) · Hepatology

Liver Diseases and ImmunityDementia and Cognitive Impairment Research

Cited by 156

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial

Leslie, W. S., Ford, I., Sattar, N., Hollingsworth, K. G., Adamson, A., Sniehotta, F. F., McCombie, L., Brosnahan, N., Ross, H., Mathers, J. C., et al. (2016) · BMC Family Practice

Diabetes Treatment and ManagementBariatric Surgery and Outcomes

Cited by 132

2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial

Al-Mrabeh, A., Hollingsworth, K. G., Shaw, J. A. M., McConnachie, A., Sattar, N., Lean, M. E. J., & Taylor, R. (2020) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 122

Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis

Hollingsworth, K. G., Newton, J. L., Taylor, R., McDonald, C., Palmer, J. M., Blamire, A. M., & Jones, D. E. J. (2008) · Clinical Gastroenterology and Hepatology

Liver Diseases and ImmunityMitochondrial Function and Pathology

Cited by 89

Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes

Trenell, M. I., Hollingsworth, K. G., Lim, E. L., & Taylor, R. (2008) · Diabetes Care

Physical Activity and HealthCardiovascular and exercise physiology

Cited by 71

Aetiology of type 2 diabetes in people with a 'normal’ body mass index: testing the personal fat threshold hypothesis

Taylor, R., Barnes, A. C., Hollingsworth, K. G., Irvine, K. M., Solovyova, A. S., Clark, L., Kelly, T., Martin-Ruiz, C., Romeres, D., Koulman, A., et al. (2023) · Clinical Science

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 71

Time course of normalization of functional β-cell capacity in the diabetes remission clinical trial after weight loss in type 2 diabetes

Zhyzhneuskaya, S. V., Al-Mrabeh, A., Peters, C., Barnes, A., Aribisala, B., Hollingsworth, K. G., McConnachie, A., Sattar, N., Lean, M. E. J., & Taylor, R. (2020) · Diabetes Care

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 70

Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial

Jabbar, A., Ingoe, L., Junejo, S., Carey, P., Addison, C., Thomas, H., Parikh, J. D., Austin, D., Hollingsworth, K. G., Stocken, D. D., et al. (2020) · JAMA

Thyroid Disorders and TreatmentsCardiovascular Function and Risk Factors

Cited by 64

Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort

Taylor, R., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Sattar, N., Welsh, P., Peters, C., Zhyzhneuskaya, S., et al. (2018) · Diabetologia

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 55

Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss

Jesuthasan, A., Zhyzhneuskaya, S., Peters, C., Barnes, A. C., Hollingsworth, K. G., Sattar, N., Lean, M. E. J., Taylor, R., & Al-Mrabeh, A. H. (2022) · Diabetologia

Diabetes, Cardiovascular Risks, and LipoproteinsLiver Disease Diagnosis and Treatment

Cited by 30

Clinical utility of liver function tests for resolution of metabolic dysfunction-associated steatotic liver disease after weight loss in the Diabetes Remission Clinical Trial

Zhyzhneuskaya, S. V., Al‐Mrabeh, A. H., Peters, C., Barnes, A. C., Hollingsworth, K. G., Welsh, P., Sattar, N., Lean, M. E. J., & Taylor, R. (2025) · Diabetic Medicine

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 6