Time Course of Normalization of Functional β-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes

Zhyzhneuskaya, Sviatlana V.; Al-Mrabeh, Ahmad; Peters, Carl; Barnes, Alison; Aribisala, Benjamin; Hollingsworth, Kieren G.; McConnachie, Alex; Sattar, Naveed; Lean, Michael E.J.; Taylor, Roy

doi:10.2337/dc19-0371

Time Course of Normalization of Functional β-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes

OBJECTIVE To assess functional β-cell capacity in type 2 diabetes during 2 years of remission induced by dietary weight loss. RESEARCH DESIGN AND METHODS A Stepped Insulin Secretion Test with Arginine was used to quantify functional β-cell capacity by hyperglycemia and arginine stimulation. Thirt…