Sadowski, Thorsten

Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)

Matthews, V., Schuster, B., Schütze, S., Bussmeyer, I., Ludwig, A., Hundhausen, C., Sadowski, T., Saftig, P., Hartmann, D., Kallen, K.-J., et al. (2003) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtease and Inhibitor Mechanisms

Cited by 390

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

Yu, J., Zhu, C., Wang, X., Kim, K., Bartolome, A., Dongiovanni, P., Yates, K. P., Valenti, L., Carrer, M., Sadowski, T., et al. (2021) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 132

Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels

Petrera, A., Gassenhuber, J., Ruf, S., Gunasekaran, D., Esser, J., Shahinian, J. H., Hübschle, T., Rütten, H., Sadowski, T., & Schilling, O. (2016) · Journal of Translational Medicine

Cardiac Fibrosis and RemodelingProtease and Inhibitor Mechanisms

Cited by 32

Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response

Petrera, A., Kern, U., Linz, D., Gomez-Auli, A., Hohl, M., Gassenhuber, J., Sadowski, T., & Schilling, O. (2016) · Journal of Proteome Research

Protease and Inhibitor MechanismsUbiquitin and proteasome pathways

Cited by 22

Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects

Tillner, J., Lehmann, A., Paehler, T., Lukacs, Z., Ruf, S., Sadowski, T., Pinquier, J., & Ruetten, H. (2016) · Clinical Pharmacology in Drug Development

Heart Failure Treatment and ManagementPharmacogenetics and Drug Metabolism

Cited by 14