Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472 · see citing works

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Kopan, R., & Ilagan, M. X. G. (2009) · Cell · doi:10.1016/j.cell.2009.03.045 · Cited by 3,631 · see citing works

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327 · see citing works

MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease

Eslam, M., Sanyal, A. J., George, J., Sanyal, A., Neuschwander-Tetri, B., Tiribelli, C., Kleiner, D. E., Brunt, E., Bugianesi, E., Yki-Järvinen, H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.312 · Cited by 3,286 · see citing works

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

Weng, A. P., Ferrando, A. A., Lee, W., Morris, J. P., Silverman, L. B., Sanchez-Irizarry, C., Blacklow, S. C., Look, A. T., & Aster, J. C. (2004) · Science · doi:10.1126/science.1102160 · Cited by 2,706 · see citing works

Notch signalling: a simple pathway becomes complex

Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620 · see citing works

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works

Fibrosis–a common pathway to organ injury and failure

Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428 · see citing works

From NASH to HCC: current concepts and future challenges

Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works

PROMO: detection of known transcription regulatory elements using species-tailored searches

Messeguer, X., Escudero, R., Farré, D., Núñez, Ó., Martı́nez, J., & Albà, M. M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.2.333 · Cited by 1,371 · see citing works

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Luedde, T., & Schwabe, R. F. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.213 · Cited by 1,345 · see citing works

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299 · see citing works

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

Li, L., Krantz, I. D., Deng, Y., Genin, A., Banta, A. B., Collins, C. C., Qi, M., Trask, B. J., Kuo, W. L., Cochran, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-243 · Cited by 1,277 · see citing works

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231 · see citing works

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

Oda, T., ELKAHLOUN, A. G., Pike, B. L., Okajima, K., Krantz, I. D., Genin, A., Piccoli, D. A., Meltzer, P. S., Spinner, N. B., Collins, F. S., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-235 · Cited by 1,150 · see citing works

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

Benedito, R., Roca, C., Sörensen, I., Adams, S., Gossler, A., Fruttiger, M., & Adams, R. H. (2009) · Cell · doi:10.1016/j.cell.2009.03.025 · Cited by 1,109 · see citing works

Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN

Farré, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg605 · Cited by 1,041 · see citing works

NAFLD, NASH and liver cancer

Michelotti, G. A., Machado, M. V., & Diehl, A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.183 · Cited by 974 · see citing works

Triggering and resolution of inflammation in NASH

Schuster, S., Cabrera, D., Arrese, M., & Feldstein, A. E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0009-6 · Cited by 943 · see citing works

Endpoints and clinical trial design for nonalcoholic steatohepatitis

Sanyal, A. J., Brunt, E. M., Kleiner, D. E., Kowdley, K. V., Chalasani, N., Lavine, J. E., Ratziu, V., & McCullough, A. J. (2011) · Hepatology · doi:10.1002/hep.24376 · Cited by 751 · see citing works

Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis

Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.311 · Cited by 671 · see citing works

Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover

Fryer, C. J., White, B., & Jones, K. A. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.014 · Cited by 627 · see citing works

rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells.

Furukawa, T., Mukherjee, S., Bao, Z., Morrow, E. M., & Cepko, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81171-x · Cited by 545 · see citing works

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

Mederacke, I., Dapito, D. H., Affò, S., Uchinami, H., & Schwabe, R. F. (2015) · Nature Protocols · doi:10.1038/nprot.2015.017 · Cited by 541 · see citing works

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Belteki, G., Haigh, J., Kabacs, N., Haigh, K., Sison, K., Costantini, F., Whitsett, J., Quaggin, S., & Nagy, A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni051 · Cited by 423 · see citing works

Targeting the gut-liver axis in liver disease

Wiest, R., Albillos, A., Trauner, M., Bajaj, J. S., & Jalan, R. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.007 · Cited by 423 · see citing works

Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis

Dobie, R., Wilson-Kanamori, J. R., Henderson, B. E. P., Smith, J. R., Matchett, K. P., Portman, J. R., Wallenborg, K., Picelli, S., Zagorska, A., Pendem, S. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.024 · Cited by 420 · see citing works

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.016 · Cited by 413 · see citing works

Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD

Carpino, G., Del Ben, M., Pastori, D., Carnevale, R., Baratta, F., Overi, D., Francis, H., Cardinale, V., Onori, P., Safarikia, S., et al. (2020) · Hepatology · doi:10.1002/hep.31056 · Cited by 381 · see citing works

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.

Gebhardt, R., & Mecke, D. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01464.x · Cited by 377 · see citing works

Pathological Features of Fatty Liver Disease

Yeh, M. M., & Brunt, E. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.056 · Cited by 339 · see citing works

CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ

Herzig, S., Hedrick, S. A., Morantte, I. G., Koo, S., Galimi, F., & Montminy, M. (2003) · Nature · doi:10.1038/nature02110 · Cited by 321 · see citing works

Hepatic Gene Expression Profiles Differentiate Presymptomatic Patients With Mild Versus Severe Nonalcoholic Fatty Liver Disease

Moylan, C. A., Pang, H., Dellinger, A. E., Suzuki, A., Garrett, M. E., Guy, C. D., Murphy, S. K., Ashley‐Koch, A. E., Choi, S. S., Michelotti, G. A., et al. (2013) · Hepatology · doi:10.1002/hep.26661 · Cited by 316 · see citing works

Dynamic Ligand Discrimination in the Notch Signaling Pathway

Nandagopal, N., Santat, L. A., LeBon, L., Sprinzak, D., Bronner-Fraser, M. E., & Elowitz, M. B. (2018) · Cell · doi:10.1016/j.cell.2018.01.002 · Cited by 311 · see citing works

Molecular mechanisms of NF-κB activation induced by bacterial lipopolysaccharide through Toll-like receptors:

Zhang, G.-L., & Ghosh, S. (2000) · Journal of Endotoxin Research · doi:10.1179/096805100101532414 · Cited by 307 · see citing works

Chronic intermittent hypoxia predisposes to liver injury†

Savransky, V., Nanayakkara, A., Vivero, A., Li, J., Bevans‐Fonti, S., Smith, P. L., Torbenson, M. S., & Polotsky, V. Y. (2007) · Hepatology · doi:10.1002/hep.21593 · Cited by 257 · see citing works

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

Chalasani, N., Wilson, L., Kleiner, D. E., Cummings, O. W., Brunt, E. M., & Ünalp, A. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.01.016 · Cited by 251 · see citing works

Emerging roles of Notch signaling in liver disease

Geisler, F., & Strazzabosco, M. (2014) · Hepatology · doi:10.1002/hep.27268 · Cited by 250 · see citing works

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0344 · Cited by 250 · see citing works

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

Hofmann, J. J., Zovein, A. C., Koh, H., Radtke, F., Weinmaster, G., & Iruela‐Arispe, M. L. (2010) · Development · doi:10.1242/dev.052118 · Cited by 247 · see citing works

Mechanism of Hypoxia-Induced NF-κB

Culver, C. A., Sundqvist, A., Mudie, S., Melvin, A., Xirodimas, D. P., & Rocha, S. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00409-10 · Cited by 229 · see citing works

Mechanisms of Notch signaling: a simple logic deployed in time and space

Henrique, D., & Schweisguth, F. (2019) · Development · doi:10.1242/dev.172148 · Cited by 208 · see citing works

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Pajvani, U. B., Shawber, C. J., Samuel, V. T., Birkenfeld, A. L., Shulman, G. I., Kitajewski, J., & Accili, D. (2011) · Nature Medicine · doi:10.1038/nm.2378 · Cited by 203 · see citing works

Hepatic glutamate metabolism: a tale of 2 hepatocytes

Brosnan, M. E., & Brosnan, J. T. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462z · Cited by 199 · see citing works

Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

Kung-Chun Chiu, D., Pui-Wah Tse, A., Law, C.-T., Ming-Jing Xu, I., Lee, D., Chen, M., Kit-Ho Lai, R., Wai-Hin Yuen, V., Wing-Sum Cheu, J., Wai-Hung Ho, D., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-2155-3 · Cited by 192 · see citing works

Rel/NF‐κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

Bash, J., Zong, W., Banga, S. S., Rivera, A., Ballard, D. W., Ron, Y., & Gélinas, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.10.2803 · Cited by 190 · see citing works

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

Yamamoto, M., Taguchi, Y., Ito-Kureha, T., Semba, K., Yamaguchi, N., & Inoue, J. (2013) · Nature Communications · doi:10.1038/ncomms3299 · Cited by 189 · see citing works

Notch is required for wingless signaling in the epidermis of Drosophila

Couso, J. P. (1994) · Cell · doi:10.1016/0092-8674(94)90195-3 · Cited by 179 · see citing works

Intestinal Microbiota and Nonalcoholic Steatohepatitis

Brandl, K., & Schnabl, B. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000349 · Cited by 169 · see citing works

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

Pajvani, U. B., Qiang, L., Kangsamaksin, T., Kitajewski, J., Ginsberg, H. N., & Accili, D. (2013) · Nature Medicine · doi:10.1038/nm.3259 · Cited by 168 · see citing works

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Yang, Y. M., Noureddin, M., Liu, C., Ohashi, K., Kim, S. Y., Ramnath, D., Powell, E. E., Sweet, M. J., Roh, Y. S., Hsin, I.-F., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat9284 · Cited by 166 · see citing works

Hypoxia Induced NF-κB

D’Ignazio, L., & Rocha, S. (2016) · Cells · doi:10.3390/cells5010010 · Cited by 156 · see citing works

Macrophage‐Specific Hypoxia‐Inducible Factor‐1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Wang, X., Ribeiro, M. D. C., Iracheta‐Vellve, A., Lowe, P., Ambade, A., Satishchandran, A., Bukong, T. N., Catalano, D. E., Kodys, K., & Szabó, G. (2018) · Hepatology · doi:10.1002/hep.30215 · Cited by 147 · see citing works

Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats

Chen, Y., Zheng, S., Qi, D., Zheng, S., Guo, J., Zhang, S., & Weng, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046512 · Cited by 140 · see citing works

The Roles of Notch Signaling in Liver Development and Disease

Adams, J., & Jafar‐Nejad, H. (2019) · Biomolecules · doi:10.3390/biom9100608 · Cited by 118 · see citing works

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin

Lefebvre, P., Lalloyer, F., Baugé, E., Pawlak, M., Gheeraert, C., Dehondt, H., Vanhoutte, J., Woitrain, E., Hennuyer, N., Mazuy, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92264 · Cited by 117 · see citing works

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

Mesarwi, O. A., Shin, M., Bevans‐Fonti, S., Schlesinger, C., Shaw, J. C., & Polotsky, V. Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168572 · Cited by 116 · see citing works

Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease

Valenti, L. V. C., Mendoza, R. M., Rametta, R., Maggioni, M., Kitajewski, C., Shawber, C. J., & Pajvani, U. B. (2013) · Diabetes · doi:10.2337/db13-0769 · Cited by 109 · see citing works

Selective regulation of Notch ligands during angiogenesis is mediated by vimentin

Antfolk, D., Sjöqvist, M., Cheng, F., Isoniemi, K. O., Duran, C. L., Rivero‐Müller, A., Antila, C., Niemi, R., Landor, S. K.-J., Bouten, C. V. C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703057114 · Cited by 108 · see citing works

Fat uses a TOLL-road to connect inflammation and diabetes

Kim, J. K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.008 · Cited by 105 · see citing works

Expression Dynamics and Functions of Hes Factors in Development and Diseases

Kobayashi, T., & Kageyama, R. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-405943-6.00007-5 · Cited by 98 · see citing works

Real-Time Imaging of Notch Activation with a Luciferase Complementation-Based Reporter

Ilagan, M. X. G., Lim, S., Fulbright, M. C., Piwnica-Worms, D. R., & Kopan, R. (2011) · Science Signaling · doi:10.1126/scisignal.2001656 · Cited by 95 · see citing works

Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation

McAlees, J. W., Whitehead, G. S., Harley, I. T. W., Cappelletti, M., Rewerts, C. L., Holdcroft, A. M., Divanovic, S., Wills-Karp, M. A., Finkelman, F. D., Karp, C. L., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.117 · Cited by 91 · see citing works

Bile duct proliferation in liver-specific Jag1 conditional knockout mice: Effects of gene dosage

Loomes, K. M., Russo, P., Ryan, M. J., Nelson, A., Underkoffler, L. A., Glover, C. L., Fu, H. Y., Gridley, T., Kaestner, K. H., & Oakey, R. J. (2007) · Hepatology · doi:10.1002/hep.21460 · Cited by 89 · see citing works

TNF induction of jagged-1 in endothelial cells is NFκB-dependent

Johnston, D. A., Dong, B., & Hughes, C. C. W. (2009) · Gene · doi:10.1016/j.gene.2009.01.003 · Cited by 80 · see citing works

Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.

Seymour, P. A., Collin, C. A., Egeskov-Madsen, A., Jørgensen, M. C., Shimojo, H., Imayoshi, I., de Lichtenberg, K. D., Kopan, R., Kageyama, R., & Serup, P. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.015 · Cited by 55 · see citing works

Identification of a novel alpha‐fetoprotein‐expressing cell population induced by the Jagged1/Notch2 signal in murine fibrotic liver

Nakano, Y., Nakao, S., Sumiyoshi, H., Mikami, K., Tanno, Y., Sueoka, M., Kasahara, D., Kimura, H., Moro, T., Kamiya, A., et al. (2017) · Hepatology Communications · doi:10.1002/hep4.1026 · Cited by 34 · see citing works

Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart

Metrich, M., Pomey, A. B., Berthonneche, C., Sarre, A., Nemir, M., & Pedrazzini, T. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv209 · Cited by 31 · see citing works

TGF-β1 signaling regulates mouse hepatic stellate cell differentiation via the Jagged1/Notch pathway

Yasen, A., Jin, X., Wang, W., Chen, Z., & Li, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.018 · Cited by 26 · see citing works

Jagged1 protein processing in the developing mammalian lens

Azimi, M., & Brown, N. L. (2019) · Biology Open · doi:10.1242/bio.041095 · Cited by 17 · see citing works

Reversal effect of Jagged1 signaling inhibition on CCl4-induced hepatic fibrosis in rats

Tang, G., Weng, Z., Song, J., & Chen, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.18484 · Cited by 11 · see citing works

Blocking development of liver fibrosis augments hepatic progenitor cell‐derived liver regeneration in a mouse chronic liver injury model

Kitade, M., Kaji, K., Nishimura, N., Seki, K., Nakanishi, K., Tsuji, Y., Sato, S., Saikawa, S., Takaya, H., Kawaratani, H., et al. (2019) · Hepatology Research · doi:10.1111/hepr.13351 · Cited by 9 · see citing works

In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization after Chronic Adaptation to Ethanol and following Partial Hepatectomy

Nilakantan, H., Kuttippurathu, L., Parrish, A., Hoek, J. B., & Vadigepalli, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140236 · Cited by 6 · see citing works

Notch signaling pathway: architecture, disease, and therapeutics

Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,145 · see citing works

Understanding the cellular interactome of non-alcoholic fatty liver disease

Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100524 · Cited by 116 · see citing works

Gut microbiome in metabolic dysfunction-associated steatotic liver disease and associated hepatocellular carcinoma

Lau, H. C.-H., Zhang, X., & Yu, J. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01089-1 · Cited by 112 · see citing works

Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells

(2025) · doi:10.1038/s41423-025-01313-7 · Cited by 97 · see citing works

Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease

Kuchay, M. S., Choudhary, N. S., & Ramos‐Molina, B. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00951.2024 · Cited by 97 · see citing works

CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

Shi, H., Wang, X., Li, F., Gerlach, B. D., Yurdagul, A., Moore, M. P., Zeldin, S., Zhang, H., Cai, B., Zheng, Z., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abp8309 · Cited by 85 · see citing works

Current status and perspective on molecular targets and therapeutic intervention strategy in hepatic ischemia-reperfusion injury

Liu, J., Luo, R., Zhang, Y., & Li, X. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0222 · Cited by 83 · see citing works

Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease

Wiering, L., Subramanian, P., & Hammerich, L. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.010 · Cited by 80 · see citing works

Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis

Kang, J., Postigo, J., Kim, K., Zhu, C., Yu, J., Meroni, M., Mayfield, B., Bartolomé, A., Dapito, D. H., Ferrante, A. W., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.165369 · Cited by 79 · see citing works

Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis

Xiao, Y., Batmanov, K., Hu, W., Zhu, K., Tom, A. Y., Guan, D., Jiang, C., Cheng, L., McCright, S. J., Yang, E. C., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adc9653 · Cited by 69 · see citing works

The gut–liver axis in immune remodeling of hepatic cirrhosis

Guan, H., Zhang, X., Kuang, M., & Yu, J. Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.946628 · Cited by 69 · see citing works

The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases

Guo, S., Zhang, Q., Guo, Y., Yin, X., Zhang, P., Mao, T., Tian, Z., & Li, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1497026 · Cited by 69 · see citing works

Molecular pathogenesis of subretinal fibrosis in neovascular AMD focusing on epithelial-mesenchymal transformation of retinal pigment epithelium

Liu, D., Zhang, C., Zhang, J., Xu, G., & Zhang, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106250 · Cited by 68 · see citing works

Role of targeting TLR4 signaling axis in liver-related diseases

Tang, Y., Zhu, L., Tao, Y., Lu, W., & Cheng, H. S. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154410 · Cited by 59 · see citing works

Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway

Chen, M., Liu, G., Fang, Z., Gao, W., Song, Y., Lei, L., Du, X., & Li, X. (2025) · Autophagy · doi:10.1080/15548627.2025.2466145 · Cited by 53 · see citing works

Spatial genomics: mapping human steatotic liver disease

Matchett, K. P., Paris, J., Teichmann, S. A., & Henderson, N. C. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00915-2 · Cited by 52 · see citing works

Exploring the effect of Weifuchun capsule on the toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritis

Wang, B., Zhou, W., Zhang, H., Wang, W., Zhang, B., & Li, S. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115930 · Cited by 51 · see citing works

Zonation in NASH – A key paradigm for understanding pathophysiology and clinical outcomes

Steinman, J. B., Salomao, M. A., & Pajvani, U. B. (2021) · Liver International · doi:10.1111/liv.15025 · Cited by 49 · see citing works

Intestinal Barrier Dysfunction and Gut Microbiota in Non-Alcoholic Fatty Liver Disease: Assessment, Mechanisms, and Therapeutic Considerations

Long, C., Zhou, X., Xia, F., & Zhou, B. (2024) · Biology · doi:10.3390/biology13040243 · Cited by 46 · see citing works

The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease

Xu, H., & Wang, L. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.792667 · Cited by 41 · see citing works

Roles of immune dysregulation in MASLD

Dong, T., Li, J., Liu, Y., Zhou, S., Wei, X., Hua, H., Tang, K., Zhang, X., Wang, Y., Wu, Z. F., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116069 · Cited by 41 · see citing works

Advances in the acting mechanism and treatment of gut microbiota in metabolic dysfunction-associated steatotic liver disease

Wu, H., Chen, J., Guo, S., Deng, J., Zhou, Z., Zhang, X., Qi, T., Yu, F., & Yang, Q. L. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2500099 · Cited by 41 · see citing works

Regulatory role and translational potential of CCL11 in liver fibrosis

Kong, M., Dong, W., Kang, A., Kuai, Y., Xu, T., Fan, Z., Shi, L., Sun, D., Lu, Y., Li, Z., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000287 · Cited by 34 · see citing works

Role of pattern recognition receptors in the development of MASLD and potential therapeutic applications

Yu, L., Gao, F., Li, Y., Su, D., Han, L., Li, Y., Zhang, X., & Feng, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116724 · Cited by 33 · see citing works

The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis

Li, X., Li, Y., Zhang, W., Jiang, F., Lin, L., Wang, Y., Wu, L., Zeng, H., & Zheng, J. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1793 · Cited by 33 · see citing works

Neutrophil extracellular traps-triggered hepatocellular senescence exacerbates lipotoxicity in non-alcoholic steatohepatitis

Xu, M. J., Xu, H., Ling, Y., Liu, J., Song, P., Fang, Z.-Q., Yue, Z., Duan, J., He, F., & Wang, L. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.03.015 · Cited by 33 · see citing works

The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression

Wang, G., Duan, J., Pu, G., Ye, C., Li, Y., Xiu, W., Xu, J., Liu, B., Zhu, Y., & Wang, C. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166413 · Cited by 33 · see citing works

GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases

Qin, Z.-X., Zuo, L., Zeng, Z., Ma, R., Xie, W., Zhu, X., & Zhou, X. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2466767 · Cited by 32 · see citing works

Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)

Subramanian, P., Hampe, J., Tacke, F., & Chavakis, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136996 · Cited by 32 · see citing works

Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice

Ding, J., Xu, M. J., Du, W., Fang, Z., Xu, H., Liu, J., Song, P., Chen, X., Li, Z., Yue, Z., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.80122 · Cited by 29 · see citing works

Crystalline Silica-Induced Proinflammatory Interstitial Macrophage Recruitment through Notch3 Signaling Promotes the Pathogenesis of Silicosis

Yuan, H., You, Y., He, Y., Wei, Y., Zhang, Y., Min, H., Li, C. R., & Chen, J. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c03980 · Cited by 28 · see citing works

Gut-derived lipopolysaccharides and metabolic endotoxemia: a critical review

Chen, B., & Gautron, L. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00355.2025 · Cited by 27 · see citing works

Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment

Zhang, N., Yao, H., Zhang, Z., Li, Z., Chen, X., Zhao, Y., Ju, R., He, J., Pan, H., Liu, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1131588 · Cited by 26 · see citing works

Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease

Fan, Y., Zhang, S., Wang, Y., Wang, H., Li, H., & Bai, L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1494560 · Cited by 25 · see citing works

Gut Microbiome in the Progression of NAFLD, NASH and Cirrhosis, and Its Connection with Biotics: A Bibliometric Study Using Dimensions Scientific Research Database

Pezzino, S., Sofia, M., Mazzone, C., Castorina, S., Puleo, S., Barchitta, M., Agodi, A., Gallo, L., Greca, G. L., & Latteri, S. (2023) · Biology · doi:10.3390/biology12050662 · Cited by 25 · see citing works

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Tzouanas, C. N., Shay, J. E. S., Sherman, M. S., Rubin, A. J., Mead, B. E., Dao, T. T., Tao, J., Lehrich, B. M., Eng, G. M., Patterson-Fortin, J., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.031 · Cited by 24 · see citing works

ADAM12 is an independent predictor of poor prognosis in liver cancer

Du, S., Sun, L., Wang, Y., Zhu, W., Gao, J., Pei, W., & Zhang, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-10608-y · Cited by 23 · see citing works

Notch Signaling Induced by Endoplasmic Reticulum Stress Regulates Cumulus-Oocyte Complex Expansion in Polycystic Ovary Syndrome

Koike, H., Harada, M., Kusamoto, A., Kunitomi, C., Xu, Z., Tanaka, T., Urata, Y., Nose, E., Takahashi, N., Wada‐Hiraike, O., et al. (2022) · Biomolecules · doi:10.3390/biom12081037 · Cited by 23 · see citing works

Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

Liu, Y., Wang, Y., Liu, B., Liu, W., Ma, Y., Cao, Y., Shi, Y., Zhang, P., Zhou, L., Zhan, Q., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2434-8 · Cited by 21 · see citing works

Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome

Mašek, J., & Andersson, E. R. (2024) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102302 · Cited by 21 · see citing works

Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second Hit

Roy, S., Saha, P., Bose, D., Trivedi, A., More, M., Xiao, S., Diehl, A. M., & Chatterjee, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216354 · Cited by 20 · see citing works

Regulation of SIRT1-TLR2/TLR4 pathway in cell communication from macrophages to hepatic stellate cells contribute to alleviates hepatic fibrosis by Luteoloside

Xiu, M.-X., Zhao, Y., Wang, X., Yuan, S., Qin, B.-F., Sun, J., Cui, L., & Song, J. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151989 · Cited by 19 · see citing works

Antisense oligonucleotide is a promising intervention for liver diseases

Lu, K., Fan, Q., & Zou, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1061842 · Cited by 19 · see citing works

Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization

Oh, A., Jeong, Y., Yu, J., Dao, T., Kang, J. K., Jung, Y. H., Im, S., Lee, S. B., Ryu, D., Pajvani, U. B., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.11.019 · Cited by 19 · see citing works

Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites

He, X.-Y., Liang, J., Li, X., Wang, Y., Zhang, X., Chen, D., Wu, L., & Wang, S. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117402 · Cited by 18 · see citing works

Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH

Conway, J. R., Pouryahya, M., Gindin, Y., Pan, D. Z., Carrasco‐Zevallos, O. M., Mountain, V., Subramanian, G. M., Montalto, M., Resnick, M. B., Beck, A. H., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101016 · Cited by 17 · see citing works

Inflammatory liver diseases and susceptibility to sepsis

Lü, H. (2024) · Clinical Science · doi:10.1042/cs20230522 · Cited by 17 · see citing works

A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide

Wang, Z., Ojogun, N., Liu, Y., Gan, L., Xiao, Z., Feng, J., Jiang, W., Chen, Y., Zou, B., Yu, C., et al. (2024) · eLife · doi:10.7554/elife.100731 · Cited by 17 · see citing works

SFAs facilitates ceramide’s de novo synthesis via TLR4 and intensifies hepatocyte lipotoxicity

Zou, Y., Tian, L., Pei, L., Hao, J., Chen, T., Qiu, J., Qiu, J., Xu, Y., Hu, X., Chen, L., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114020 · Cited by 16 · see citing works

Filamin A is overexpressed in non-alcoholic steatohepatitis and contributes to the progression of inflammation and fibrosis

Lu, Y. C., Wang, M., Zhao, M., Zhang, Q., Qian, R., Hu, Z., Qi, K., Yu, L., Wang, L., Lai, Q., et al. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.02.048 · Cited by 15 · see citing works

Hepatocyte CD36 protects mice from NASH diet-induced liver injury and fibrosis via blocking N1ICD production

Li, Y., Zhang, L., Jiao, J., Ding, Q., Li, Y., Zhao, Z., Luo, J., Chen, Y., Ruan, X. Z., & Zhao, L. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166800 · Cited by 15 · see citing works

Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies

Hao, C. H. E. N., Zhou, Y., Hao, H., & XIONG, J. (2024) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(24)60690-4 · Cited by 15 · see citing works

Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation

Hu, J., Zheng, Y., Ying, H., Ma, H., Li, L., & Zhao, Y. (2022) · Nutrients · doi:10.3390/nu14183796 · Cited by 15 · see citing works

Mechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomics and gut microbiome

Sun, C., Lan, F., Zhou, Q., Guo, X., Jin, J., Wen, C., Guo, Y., Hou, Z., Zheng, J., Wu, G., et al. (2024) · GigaScience · doi:10.1093/gigascience/giae023 · Cited by 14 · see citing works

A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease

Wang, Y., Wang, J., Zhou, Z., Gu, Y., Zhu, X., Yi, Z., Cao, C., He, L., Du, Y., Guo, H., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.11.052 · Cited by 13 · see citing works

Regulatory Mechanisms of Phenolic Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review

Zhang, S., Shen, C., Han, D., Wang, Y., & Guan, F. (2025) · Antioxidants · doi:10.3390/antiox14070760 · Cited by 13 · see citing works

Multimodal Learning-based Prediction for Nonalcoholic Fatty Liver Disease

Chen, Y., Chen, X., Han, Y., Li, H., Zhao, D., Li, J., Wang, X., & Zhou, Y. (2025) · Machine Intelligence Research · doi:10.1007/s11633-024-1506-4 · Cited by 12 · see citing works

Targeting the gut-liver axis with dietary polyphenols to ameliorate metabolic dysfunction-associated steatotic liver disease: advances in molecular mechanisms

Hu, Z., He, Z., Wang, Y., Chu, Z., Zhou, Y., Li, W., Lu, J., Lin, Q., & Luo, F. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2556470 · Cited by 12 · see citing works

The beneficial effects of l ‐carnitine and infliximab in methotrexate‐induced hepatotoxicity: Emphasis on Notch1/Hes‐1 signaling

Radwan, S. M., Abdel‐Latif, G. A., Abbas, S. S., Elmongy, N. F., & Wasfey, E. F. (2023) · Archiv der Pharmazie · doi:10.1002/ardp.202300312 · Cited by 11 · see citing works

Single-Cell and Spatial Multi-Omics Analysis Reveal That Targeting JAG1 in Epithelial Cells Reduces Periodontal Inflammation and Alveolar Bone Loss

Kuang, S., Yang, J., Shen, Z., Xia, J., & Lin, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413255 · Cited by 11 · see citing works

Molecular Mechanisms and Mediators of Hepatotoxicity Resulting from an Excess of Lipids and Non-Alcoholic Fatty Liver Disease

Finelli, C. (2023) · Gastrointestinal Disorders · doi:10.3390/gidisord5020020 · Cited by 11 · see citing works

Inhibition of hepatic PCSK9 as a novel therapeutic target ameliorates metabolic steatohepatitis in mice

Mijiti, T., Chen, X., Ma, X., XiuMin, M., XiuMin, M., & Chen, B. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113621 · Cited by 10 · see citing works

Periostin-mediated NOTCH1 activation between tumor cells and HSCs crosstalk promotes liver metastasis of small cell lung cancer

Lou, L., Peng, K., Ouyang, S., Ding, W., Mo, J., Yan, J., Gong, X., Liu, G., Lu, J., Yue, P., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03266-7 · Cited by 10 · see citing works

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

Tan, Y., Hu, Y., Yang, Y., & Chu, H. (2025) · MedComm · doi:10.1002/mco2.70532 · Cited by 10 · see citing works

MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice

Hu, J., Du, H., Yuan, Y., Guo, P., Yang, J., Yin, X., Liu, J., Wu, S., Wan, J., & Gong, X. (2022) · Mediators of Inflammation · doi:10.1155/2022/5791915 · Cited by 10 · see citing works

Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota

Zhang, J., Sun, Z., Xu, L., Wang, Y., Wang, Y., & Dong, B. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1543003 · Cited by 9 · see citing works

Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2

Chang, C., Wang, M., Li, J., Qi, S., Yu, X., Xu, J., & Shi, S. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03488-3 · Cited by 9 · see citing works

Genomic medicine in hepatology: mechanisms and liver treatment strategies

Kozlov, D., Rodimova, S. A., Filatov, P. V., Mozherov, A. M., Timashev, P. S., Zyuzin, M. V., & Kuznetsova, D. S. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01358-4 · Cited by 9 · see citing works

Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives

Zhu, Z., Chen, Y., Qin, X., Liu, S., Wang, J., & Ren, H. (2023) · Smart Medicine · doi:10.1002/smmd.20220029 · Cited by 8 · see citing works

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Alhamar, G., Razafiarison, J., Alzaïd, F., Al‐Mulla, F., & Ahmad, R. (2026) · Obesity Reviews · doi:10.1111/obr.70107 · Cited by 8 · see citing works

Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor

Kwan, S., Slayden, A. N., Coronado, A. R., Marquez, R. C., Chen, H., Wei, P., Savage, M. I., Vornik, L. A., Fox, J. T., Sei, S., et al. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-22-0332 · Cited by 8 · see citing works

FTY‐720 alleviates diabetes‐induced liver injury by inhibiting oxidative stress and inflammation

Ye, H., Sun, M., Jin, Z., Yuan, Y., & Weng, H. (2023) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12897 · Cited by 8 · see citing works

Reactive Oxygen Species-Responsive Delivery of a Notch Inhibitor to Alleviate Nonalcoholic Steatohepatitis by Inhibiting Hepatic de Novo Lipogenesis and Inflammation

Chen, J.-H., Zhang, J., Xia, Y., Li, J., Jia, Q., Zhang, Z., Jing, X., Xu, Y., Zou, L., Wang, L., et al. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00070 · Cited by 7 · see citing works

Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications

Zhao, J., Yue, P., Mi, N., Li, M., Fu, W., Zhang, X., Gao, L., Bai, M., Tian, L., Jiang, N., et al. (2024) · Medical Review · doi:10.1515/mr-2024-0029 · Cited by 7 · see citing works

HMGB1 Accelerates Wound Healing by Promoting the Differentiation of Epidermal Stem Cells via the “HMGB1-TLR4-Wnt/Notch” Axis

Zhen, M., Zhu, Y., Wang, P., Liu, X., Zhu, J., Liu, H., Li, J., Zhao, J., & Shu, B. (2024) · Advances in Wound Care · doi:10.1089/wound.2023.0130 · Cited by 7 · see citing works

Dietary Inflammatory index and its association with fatty liver disease: a study in obese and non-obese populations

Fu, W., Zhao, J., Cheng, G., Xu, L.-B., Lyu, L., & Ding, Y. (2025) · BMC Gastroenterology · doi:10.1186/s12876-024-03585-1 · Cited by 7 · see citing works

Effects of the interaction of Notch and TLR4 pathways on inflammation and heart function in septic heart

Liu, Z., Li, W., Cao, Y., Zhang, X., Yang, K., Yin, F., Yang, M., & Peng, P. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0076 · Cited by 7 · see citing works

Jagged-1/Notch Pathway and Key Transient Markers Involved in Biliary Fibrosis during Opisthorchis felineus Infection

Kovner, A. V., Zaparina, O. G., Kapushchak, Y. K., Minkova, G., Mordvinov, V. A., & Pakharukova, M. Y. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7110364 · Cited by 7 · see citing works

Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects

Mašek, J., Filipovic, I., Hul, N. V., Belicová, L., Jiroušková, M., Oliveira, D. V., Frontino, A. M., Hankeová, S., He, J., Turetti, F., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00145-8 · Cited by 6 · see citing works

Notch Signaling Aggravates Helicobacter pylori–Induced Inflammation by Promoting Macrophage Activation and Proinflammatory Th1/Th17 Responses

He, Y., Xiao, D., Zhu, H., Chen, C., Liu, Q., Xie, J., Wei, L., Dai, Y., Ning, Y., & Li, Y. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.04.007 · Cited by 6 · see citing works

Antisense oligonucleotide-mediated upregulation of Jag1 ameliorates liver disease phenotypes in a mouse model of Alagille syndrome

Zhang, L., Niknejad, N., Li, J. J., Peng, L., Jain, S., Steiner, D., Thai, R., Yu, X. X., Wang, Y., & Liang, X. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102694 · Cited by 6 · see citing works

The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21

He, Y., Li, H., Shi, Q., Liu, Y., Pan, Q., & He, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07401-w · Cited by 6 · see citing works

Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice

Macêdo, A. P. A., Neto, I. V. D. S., Antonio, G. C. F., Gaspar, R. C., de Lima, R. D., Dias, L. M., Vieira, R. F. L., Muñoz, V. R., Brunelli, D. T., da Silva, A. S. R., et al. (2025) · Nutrition · doi:10.1016/j.nut.2025.112691 · Cited by 5 · see citing works

Immune Microenvironment on the Molecular Mechanisms and Therapeutic Targets of MAFLD

Jiang, Z., Qian, B., Xu, T., Bai, J., & Fu, W. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s530451 · Cited by 5 · see citing works

Elevated expression of Toll-like receptor 4 and cytokines in both serum and myometrium at term may serve as promising biomarkers for uterine activation preceding labor

Chen, Z., Li, J., Wenjuan, X., Wu, X., Xiang, F., Li, X., Zhang, M., Zheng, J., Kang, X., & Wu, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1255925 · Cited by 5 · see citing works

Direct degradation and stabilization of proteins: New horizons in treatment of nonalcoholic steatohepatitis

Wang, Y., Zheng, J., Long, Y., Wu, W., & Zhu, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115989 · Cited by 5 · see citing works

β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice

Suda, N., Bartolomé, A., Liang, J., Son, J., Yagishita, Y., Siebel, C. W., Accili, D., Ding, H., & Pajvani, U. B. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101894 · Cited by 5 · see citing works

Prediction of the mechanisms of action of Qutan Huoxue decoction in non-alcoholic steatohepatitis (NASH): a network pharmacology study and experimental validation

Wu, X., Zhang, Y., Ding, Z., Yin, Y., Peng, M., Wang, J., & Zhu, X. (2023) · Pharmaceutical Biology · doi:10.1080/13880209.2023.2182892 · Cited by 5 · see citing works

Hepatocyte KCTD17-mediated SERPINA3 inhibition determines liver fibrosis in metabolic dysfunction-associated steatohepatitis

Jeong, Y., Oh, A., Jung, Y. H., Jung, K. H., Lee, S., Carrer, M., Lee, S. B., Valenti, L. V. C., Pajvani, U. B., & Kim, K. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01499-w · Cited by 4 · see citing works

Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice

Xie, G., Zhang, Q., Fang, Z., Che, L., Lin, Y., Xu, S., Zhuo, Y., Hua, L., Jiang, X., Li, J., et al. (2023) · Antioxidants · doi:10.3390/antiox12071355 · Cited by 4 · see citing works

Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis

Sosa, R. A., Terry, A. Q., Ito, T., Naini, B. V., Zheng, Y. Y., Pickering, H. C., Nevarez‐Mejia, J., Busuttil, R. W., Gjertson, D. W., Kupiec‐Weglinski, J. W., et al. (2023) · Transplantation Direct · doi:10.1097/txd.0000000000001550 · Cited by 3 · see citing works

Multiscale insights into cornusideʼs effects on NAFLD: A cross-disciplinary integrating bioinformatics, computational chemistry, and machine learning

Gao, G., Zhang, X., Wang, Z., Xu, J., Wang, J., Liu, T., & Xie, Z. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156809 · Cited by 3 · see citing works

Notch signaling in metabolic diseases: A key regulator and potential target

Xi, Z., Zhang, J., & Bao, M. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152492 · Cited by 3 · see citing works

Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by SYK/SH3BP2 Signaling Pathway

Liu, Y. Y., Tao, J., Tan, D., Zheng, F., Su, Z., Yuan, J., Zhu, C., Zheng, Z., Zhou, X., & Luo, D. (2026) · Research · doi:10.34133/research.1100 · Cited by 3 · see citing works

Molecular mechanisms and pathogenesis of MASH

Gallage, S., Govaere, O., Anstee, Q. M., Shulman, G. I., Tacke, F., & Heikenwälder, M. F. (2026) · Nature · doi:10.1038/s41586-026-10529-0 · Cited by 3 · see citing works

RAGE is a key regulator of ductular reaction-mediated fibrosis during cholestasis

Lam, W.-L. M., Gabernet, G., Poth, T., Sator‐Schmitt, M., Oquendo, M. B., Kast, B., Lohr, S., Ponti, A. D., Weiß, L., Schneider, M., et al. (2025) · EMBO Reports · doi:10.1038/s44319-024-00356-7 · Cited by 3 · see citing works

The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease

Grandt, J., Johansen, C. D., Jensen, A. H., Werge, M. P., Rashu, E. B., Møller, A., Junker, A. E., Hobolth, L., Mortensen, C., Vyberg, M., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0307345 · Cited by 3 · see citing works

Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early clinical investigation

Ocker, M., & Neureiter, D. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2288075 · Cited by 3 · see citing works

Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands

Júnior, W. F. D. S., Costa, K. M. D. O., Oliveira, H. M. D. C., Antunes, M. M., Mafra, K., Nakagaki, B. N., da Silva, P. S. C., Megale, J. D., de Sales, S. C., Caixeta, D. C., et al. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100744 · Cited by 3 · see citing works

Notch signaling in liver diseases: mechanistic insights and therapeutic implications

Shi, Q., Lou, N., Huang, D., & Fu, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1770031 · Cited by 2 · see citing works

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0344 · Cited by 250 · see citing works

Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers

Wang, X., Moore, M. P., Shi, H., Miyata, Y., Donnelly, S. K., Radiloff, D. R., & Tabas, I. A. (2023) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2023.101165 · Cited by 22 · see citing works

Notch and Nonalcoholic Fatty Liver and Fibrosis

Romeo, S. (2019) · New England Journal of Medicine · doi:10.1056/nejmcibr1815636 · Cited by 49 · see citing works

Hepatocyte Notch in non-alcoholic steatohepatitis (NASH)-associated liver fibrosis and cancer

Zhu, C. (2019) · doi:10.7916/d8-877b-v389

Jagged-1 signalling is required in liver fibrogensis

Weng, H., Liu, Y., Ilkavets, I., Shen, H., Zimmer, V., Lammert, F., Mueller, A. J., Herweck, F., Stump, C., Mertens, P., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0030-1269508