Lehner, Paul J.

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Mlcochova, P., Kemp, S. A., Dhar, M. S., Papa, G., Meng, B., Ferreira, I. A. T. M., Datir, R., Collier, D. A., Albecka, A., Singh, S., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 1,337

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., et al. (2022) · Nature

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,146

SARS-CoV-2 evolution during treatment of chronic infection

Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,097

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Burr, M. L., Sparbier, C. E., Chan, Y.-C., Williamson, J. C., Woods, K., Beavis, P. A., Lam, E. Y. N., Henderson, M. A., Bell, C. C., Stolzenburg, S., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 946

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R. P., Lim, E. Y., Touizer, E., Meng, B., Abdullahi, A., The CITIID-NIHR BioResource COVID-19 Collaboration, Principal Investigators, et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 751

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., Kemp, S. A., Bassi, J., Pinto, D., Silacci-Fregni, C., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 728

NOTCH1 mediates a switch between two distinct secretomes during senescence

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M. P., Matheson, N. J., Patten, D. A., Shetty, S., Parry, A. J., Menon, S., Salama, R., et al. (2016) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 522

Neural stem cells traffic functional mitochondria via extracellular vesicles

Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., van den Bosch, A., Leonardi, T., et al. (2021) · PLOS Biology

Extracellular vesicles in diseaseMesenchymal stem cell research

Cited by 263

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

Robbez-Masson, L., Tie, C. H. C., Conde, L., Tunbak, H., Husovsky, C., Tchasovnikarova, I. A., Timms, R. T., Herrero, J., Lehner, P. J., & Rowe, H. M. (2018) · Genome Research

Chromosomal and Genetic VariationsGenomics and Chromatin Dynamics

Cited by 221

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Markson, G., Kiel, C., Hyde, R., Brown, S., Charalabous, P., Bremm, A., Semple, J., Woodsmith, J., Duley, S., Salehi-Ashtiani, K., et al. (2009) · Genome Research

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 157

Latency-Associated Degradation of the MRP1 Drug Transporter During Latent Human Cytomegalovirus Infection

Weekes, M. P., Tan, S. Y. L., Poole, E., Talbot, S., Antrobus, R., Smith, D. L., Montag, C., Gygi, S. P., Sinclair, J. H., & Lehner, P. J. (2013) · Science

Cytomegalovirus and herpesvirus researchDrug Transport and Resistance Mechanisms

Cited by 131

Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses

Needham, E. J., Ren, A. L., Digby, R. J., Norton, E. J., Ebrahimi, S., Outtrim, J. G., Chatfield, D. A., Manktelow, A. E., Leibowitz, M. M., Newcombe, V. F. J., et al. (2022) · Brain

Long-Term Effects of COVID-19COVID-19 Clinical Research Studies

Cited by 90

Proteomic Plasma Membrane Profiling Reveals an Essential Role for gp96 in the Cell Surface Expression of LDLR Family Members, Including the LDL Receptor and LRP6

Weekes, M. P., Antrobus, R., Talbot, S., Hör, S., Simecek, N., Smith, D. L., Bloor, S., Randow, F., & Lehner, P. J. (2012) · Journal of Proteome Research

Heat shock proteins researchEndoplasmic Reticulum Stress and Disease

Cited by 82

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein

Shilts, J., Crozier, T. W. M., Teixeira-Silva, A., Gabaev, I., Greenwood, E. J. D., Watson, S. J., Ortmann, B. M., Gawden-Bone, C. M., Pauzaite, T., Hoffmann, M., et al. (2021) · PLoS Biology

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 28

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

Randzavola, L. O., Mortimer, P. M., Garside, E., Dufficy, E. R., Schejtman, A., Roumelioti, G., Yu, L., Pardo, M., Spirohn, K., Tolley, C., et al. (2022) · eLife

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 24

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

Randzavola, L. O., Mortimer, P. M., Garside, E., Dufficy, E. R., Schejtman, A., Roumelioti, G., Yu, L., Pardo, M., Spirohn, K., Tolley, C., et al. (2021) · eLife

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 24