Cited by 131Cytomegalovirus and herpesvirus researchDrug Transport and Resistance MechanismsHerpesvirus Infections and Treatments

Latency-Associated Degradation of the MRP1 Drug Transporter During Latent Human Cytomegalovirus Infection

Open access
Weekes, Michael P., Tan, Shireen Y. L., Poole, Emma, Talbot, Suzanne, Antrobus, Robin, Smith, Duncan L., Montag, Christina, Gygi, Steven P. +2 more·2013·Science

Abstract

Hide-and-Seek Virus: Human cytomegalovirus (HCMV) establishes latent infection in human progenitor dendritic cells, causing significant morbidity and mortality on reactivation, which may occur in transplantation patients who are immunosuppressed. Neither detection nor selective removal of rare latent HCMV-infected cells has been possible. Weekes et al. (p. 199 ) have found that the multidrug-resistant ABC transporter, multidrug resistance–associated protein-1 (MRP1) is down-regulated during latent HCMV infection. Consequently, cytotoxic MRP1-specific substrates are not exported from HCMV-infected cells and accumulate—leading to cell death, which could potentially provide a mechanism for eliminating infected cells prior to transplantation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.1235047

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Weekes, M. P., Tan, S. Y. L., Poole, E., Talbot, S., Antrobus, R., Smith, D. L., Montag, C., Gygi, S. P., Sinclair, J. H., & Lehner, P. J.
Affiliations
  • University of Cambridge (GB)
  • University of Manchester (GB)
  • Charité – Universitätsmedizin Berlin (DE)
  • Harvard University (US)
Corresponding author
  • Weekes, Michael P.
  • Tan, Shireen Y. L.
  • Poole, Emma
  • Talbot, Suzanne
  • Lehner, Paul J.
Venue
Science
Published
2013-04-12
Volume
340
Issue
6129
Pages
199-202
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2074715606
Cited by
131
References
42
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 18 · 2020: 9 · 2019: 12 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 16 · 2014: 20 · 2013: 10
FWCI
14.19
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Wellcome Trust (093966, 084957, 093966/Z/10/Z, 100140, 084957/Z/08/Z)
  • Medical Research Council (MR/K021087/1)
Topics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Keywords
human cytomegalovirus, viral latency, MRP1, multidrug resistance-associated protein, drug transporters, myeloid progenitor cells, CD14+ cells, CD34+ cells, stable isotope labeling
MeSH terms
Cytomegalovirus Infections, Cytomegalovirus, Dendritic Cells, Humans, Lysosomes, Monocytes, Vincristine, Viral Proteins, Down-Regulation, Virus Latency, Antigens, CD34, ATP-Binding Cassette, Sub-Family C Proteins, Cell Line, Tumor, Monocyte-Macrophage Precursor Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review