Lichtenthaler, Stefan F.

ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

Kuhn, P., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Roßner, S., & Lichtenthaler, S. F. (2010) · The EMBO Journal

Alzheimer's disease research and treatmentsProtease and Inhibitor Mechanisms

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γ-secretase directly sheds the survival receptor BCMA from plasma cells

Laurent, S. A., Hoffmann, F. S., Kuhn, P.-H., Cheng, Q., Chu, Y., Schmidt-Supprian, M., Hauck, S. M., Schuh, E., Krumbholz, M., Rübsamen, H., et al. (2015) · Nature Communications

NF-κB Signaling PathwaysT-cell and B-cell Immunology

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Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

Cunha, M. I., Su, M., Cantuti-Castelvetri, L., Müller, S. A., Schifferer, M., Djannatian, M., Alexopoulos, I., van der Meer, F., Winkler, A., van Ham, T. J., et al. (2020) · Journal of Experimental Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

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Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

Sebastian Monasor, L., Müller, S. A., Colombo, A. V., Tanrioever, G., König, J., Roth, S., Liesz, A., Berghofer, A., Piechotta, A., Prestel, M., et al. (2020) · eLife

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Spatial proteomics in three-dimensional intact specimens

Bhatia, H. S., Brunner, A.-D., Öztürk, F., Kapoor, S., Rong, Z., Mai, H., Thielert, M., Ali, M., Al-Maskari, R., Paetzold, J. C., et al. (2022) · Cell

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

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Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

Pigoni, M., Wanngren, J., Kuhn, P.-H., Munro, K. M., Gunnersen, J. M., Takeshima, H., Feederle, R., Voytyuk, I., De Strooper, B., Levasseur, M. D., et al. (2016) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsProtease and Inhibitor Mechanisms

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Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

Zhu, K., Xiang, X., Filser, S., Marinković, P., Dorostkar, M. M., Crux, S., Neumann, U., Shimshek, D. R., Rammes, G., Haass, C., et al. (2018) · Biological Psychiatry

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

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An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome

Tüshaus, J., Müller, S. A., Kataka, E. S., Zaucha, J., Sebastian Monasor, L., Su, M., Güner, G., Jocher, G., Tahirovic, S., Frishman, D., et al. (2020) · The EMBO Journal

Advanced Proteomics Techniques and ApplicationsNeuroinflammation and Neurodegeneration Mechanisms

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Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Liu, S., Hossinger, A., Heumüller, S.-E., Hornberger, A., Buravlova, O., Konstantoulea, K., Müller, S. A., Paulsen, L., Rousseau, F., Schymkowitz, J., et al. (2021) · Nature Communications

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

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Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2

Lichtenthaler, S. F., Tschirner, S. K., & Steiner, H. (2022) · Current Opinion in Neurobiology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Reactivated endogenous retroviruses promote protein aggregate spreading

Liu, S., Heumüller, S.-E., Hossinger, A., Müller, S. A., Buravlova, O., Lichtenthaler, S. F., Denner, P., & Vorberg, I. M. (2023) · Nature Communications

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

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Expression of the Anti-amyloidogenic Secretase ADAM10 Is Suppressed by Its 5′-Untranslated Region

Lammich, S., Buell, D., Zilow, S., Ludwig, A.-K., Nuscher, B., Lichtenthaler, S. F., Prinzen, C., Fahrenholz, F., & Haass, C. (2010) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsRNA and protein synthesis mechanisms

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TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

Feiten, A. F., Dahm, K., Schlepckow, K., van Lengerich, B., Suh, J. H., Reifschneider, A., Wefers, B., Bartos, L. M., Wind-Mark, K., de Weerd, L., et al. (2026) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae

Rother, C., Uhlmann, R. E., Müller, S. A., Schelle, J., Skodras, A., Obermüller, U., Häsler, L. M., Lambert, M., Baumann, F., Xu, Y., et al. (2022) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Myeloid cell–specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease

Dinkel, L., Hummel, S., Zenatti, V., Malara, M., Tillmann, Y., Colombo, A., Monasor, L. S., Suh, J. H., Logan, T., Roth, S., et al. (2024) · Science Translational Medicine

Lysosomal Storage Disorders ResearchNeuroinflammation and Neurodegeneration Mechanisms

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The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, M., Jeskanen, H., Rolova, T., Kervinen, I., Hellén, M., Heikkinen, S., Koivisto, H., Jokivarsi, K., Müller, S. A., Koivumäki, E.-M., et al. (2025) · Journal of Neuroinflammation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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