Iwai, Shigenori

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature

DNA Repair MechanismsGenetic factors in colorectal cancer

Cited by 1,292

Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair

Sugasawa, K., Ng, J. M. Y., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P. M., Hanaoka, F., Bootsma, D., & Hoeijmakers, J. H. J. (1998) · Molecular Cell

DNA Repair MechanismsNuclear Structure and Function

Cited by 899

UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex

Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., et al. (2005) · Cell

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 576

Mechanisms of accurate translesion synthesis by human DNA polymerase η

Masutani, C., Kusumoto, R., Iwai, S., & Hanaoka, F. (2000) · The EMBO Journal

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 504

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

Fischer, E. S., Scrima, A., Böhm, K., Matsumoto, S., Lingaraju, G. M., Faty, M., Yasuda, T., Cavadini, S., Wakasugi, M., Hanaoka, F., et al. (2011) · Cell

Ubiquitin and proteasome pathwaysDNA Repair Mechanisms

Cited by 460

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

Scrima, A., Koníčková, R., Czyzewski, B. K., Kawasaki, Y., Jeffrey, P. D., Groisman, R., Nakatani, Y., Iwai, S., Pavletich, N. P., & Thomä, N. H. (2008) · Cell

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 441

A multistep damage recognition mechanism for global genomic nucleotide excision repair

Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., & Hanaoka, F. (2001) · Genes & Development

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 435

Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

McCulloch, S. D., Kokoska, R. J., Masutani, C., Iwai, S., Hanaoka, F., & Kunkel, T. A. (2004) · Nature

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 246

The intricate structural chemistry of base excision repair machinery: Implications for DNA damage recognition, removal, and repair

Hitomi, K., Iwai, S., & Tainer, J. A. (2007) · DNA Repair

DNA Repair MechanismsEnzyme Structure and Function

Cited by 220

Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning

Sugasawa, K., Akagi, J.-I., Nishi, R., Iwai, S., & Hanaoka, F. (2009) · Molecular Cell

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 205

How does RNase H recognize a DNA.RNA hybrid?

Nakamura, H., Oda, Y., Iwai, S., Inoue, H., Ohtsuka, E., Kanaya, S., Kimura, S., Katsuda, C., Katayanagi, K., & Morikawa, K. (1991) · Proceedings of the National Academy of Sciences

DNA and Nucleic Acid ChemistryEnzyme Structure and Function

Cited by 193

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis

Kanaya, S., Kohara, A., Miura, Y., Sekiguchi, A., Iwai, S., Inoue, H., Ohtsuka, E., & Ikehara, M. (1990) · Journal of Biological Chemistry

Enzyme Structure and FunctionRNA and protein synthesis mechanisms

Cited by 180

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA

Wittschieben, B. Ø., Iwai, S., & Wood, R. D. (2005) · Journal of Biological Chemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 159

The XPC-HR23B complex displays high affinity and specificity for damaged DNA in a true-equilibrium fluorescence assay

Hey, T., Lipps, G., Sugasawa, K., Iwai, S., Hanaoka, F., & Krauss, G. (2002) · Biochemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 114

Blockage of RNA Polymerase II at a Cyclobutane Pyrimidine Dimer and 6-4 Photoproduct

Mei Kwei, J. S., Kuraoka, I., Horibata, K., Ubukata, M., Kobatake, E., Iwai, S., Handa, H., & Tanaka, K. (2004) · Biochemical and Biophysical Research Communications

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 82

Investigation of the Cyclobutane Pyrimidine Dimer (CPD) Photolyase DNA Recognition Mechanism by NMR Analyses

Torizawa, T., Ueda, T., Kuramitsu, S., Hitomi, K., Todo, T., Iwai, S., Morikawa, K., & Shimada, I. (2004) · Journal of Biological Chemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 44